1-Deoxypentalenic acid 11beta-hydroxylase

1-deoxypentalenic acid 11beta-hydroxylase
Identifiers
EC no.	1.14.11.35
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

1-deoxypentalenic acid 11beta-hydroxylase (EC 1.14.11.35, PTLH (gene), SAV2991 (gene), PNTH (gene)) is an enzyme with systematic name 1-deoxypentalenic acid,2-oxoglutarate:oxygen oxidoreductase. ^{[1] [2]} This enzyme catalyses the following chemical reaction

1-deoxypentalenate + 2-oxoglutarate + O₂${\displaystyle \rightleftharpoons }$ 1-deoxy-11beta-hydroxypentalenate + succinate + CO₂

1-Deoxypentalenic acid 11beta-hydroxylase contains Fe(II) and ascorbate.

References

1. You Z, Omura S, Ikeda H, Cane DE (May 2006). "Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlH, a non-heme iron dioxygenase of Streptomyces avermitilis". Journal of the American Chemical Society. 128 (20): 6566–7. Bibcode:2006JAChS.128.6566Y. doi:10.1021/ja061469i. PMC   2533727 . PMID   16704250.
2. You Z, Omura S, Ikeda H, Cane DE, Jogl G (December 2007). "Crystal structure of the non-heme iron dioxygenase PtlH in pentalenolactone biosynthesis". The Journal of Biological Chemistry. 282 (50): 36552–60. doi: 10.1074/jbc.M706358200 . PMC   3010413 . PMID   17942405.

External links

• 1-deoxypentalenic+acid+11beta-hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)