60S ribosomal protein L15

RPL15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J7R, 4V5Z, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC,%%s3J7R, 4V5Z, 4V6X, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 5AJ0, 3J7Q, 4UG0, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL15 , DBA12, EC45, L15, RPL10, RPLY10, RPYL10, ribosomal protein L15
External IDs	OMIM: 604174 MGI: 1913730 HomoloGene: 37713 GeneCards: RPL15
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p24.2 Start 23,916,591 bp [1] End 23,924,374 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14 A1|14 Start 4,198,305 bp [2] End 4,201,873 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium middle temporal gyrus gallbladder canal of the cervix caput epididymis ganglionic eminence stromal cell of endometrium anterior pituitary right uterine tube right coronary artery Top expressed in morula yolk sac primitive streak lip barrel cortex superior cervical ganglion superior frontal gyrus ganglionic eminence trigeminal ganglion condyle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding structural constituent of ribosome cadherin binding RNA binding Cellular component cytosol ribosome membrane intracellular anatomical structure extracellular exosome nucleus cytosolic large ribosomal subunit A band Biological process cytoplasmic translation protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing response to ethanol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6138 66480 Ensembl ENSG00000174748 ENSMUSG00000012405 UniProt P61313 Q9CZM2 RefSeq (mRNA) NM_001253379 NM_001253380 NM_001253382 NM_001253383 NM_001253384 NM_002948 NM_025586 NM_001359897 NM_001359899 RefSeq (protein) NP_001240308 NP_001240309 NP_001240311 NP_001240312 NP_001240313 NP_002939 NP_001240308.1 NP_001240309.1 NP_001240311.1 NP_001240312.1 NP_002939.2 NP_079862 NP_001346826 NP_001346828 Location (UCSC) Chr 3: 23.92 – 23.92 Mb Chr 14: 4.2 – 4.2 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L15 is a protein that in humans is encoded by the RPL15 gene. ^{[5] [6]}

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L15E family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Although this gene has been referred to as RPL10, its official symbol is RPL15. This gene has been shown to be overexpressed in some esophageal tumors compared to normal matched tissues. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000174748 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000012405 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi: 10.1101/gr.8.5.509 . PMID   9582194.
6. "Entrez Gene: RPL15 ribosomal protein L15".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Adams MD, Dubnick M, Kerlavage AR, et al. (1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. Bibcode:1992Natur.355..632A. doi:10.1038/355632a0. PMID   1538749. S2CID   4234345.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Wang Q, Yang C, Zhou J, et al. (2001). "Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer". Gene. 263 (1–2): 205–9. doi:10.1016/S0378-1119(00)00570-9. PMID   11223259.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC   155282 . PMID   11875025.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Wang H, Zhao LN, Li KZ, et al. (2006). "Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer". BMC Cancer. 6: 91. doi: 10.1186/1471-2407-6-91 . PMC   1459873 . PMID   16608517.