60S ribosomal protein L23a

RPL23A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 3J7R, 4V5Z, 4UJD, 3J7P, 4D67, 3J92, 4D5Y, 3J7Q, 4UJE, 3J7O, 4UJC
Identifiers
Aliases	RPL23A , L23A, MDA20, ribosomal protein L23a
External IDs	OMIM: 602326; MGI: 3040672; HomoloGene: 133569; GeneCards: RPL23A; OMA:RPL23A - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q11.2 Start 28,719,985 bp [1] End 28,724,359 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B5 Start 78,071,758 bp [2] End 78,074,410 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary Achilles tendon canal of the cervix right ovary right uterine tube ectocervix pituitary gland skin of abdomen body of uterus skin of leg Top expressed in ovary epiblast ganglionic eminence thymus ventricular zone uterus embryo adrenal gland lip blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function rRNA binding structural constituent of ribosome protein binding cadherin binding RNA binding TORC2 complex binding large ribosomal subunit rRNA binding Cellular component cytoplasm cytosol ribosome intracellular anatomical structure nucleolus cytosolic large ribosomal subunit extracellular exosome nucleus TORC2 complex Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane ribosomal large subunit assembly translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cell population proliferation protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6147 268449 Ensembl ENSG00000198242 ENSMUSG00000058546 UniProt P62750 P62751 RefSeq (mRNA) NM_000984 NM_207523 RefSeq (protein) NP_000975 NP_997406 Location (UCSC) Chr 17: 28.72 – 28.72 Mb Chr 11: 78.07 – 78.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Large ribosomal subunit protein uL23 is a protein that in humans is encoded by the RPL23A gene. ^{[5] [6]}

Function

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 rRNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the universal ribosomal protein uL23 family. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A , U42B , U101A , and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. ^[6]

Clinical significance

L23a has been identified as an autoimmune target that causes a form of rheumatoid arthritis in mice and which also causes a reaction from T cells and autoantibodies from human rheumatoid arthritis patients. ^[7]

Pseudogenes

95 related pseudogenes are known, with symbols RPL23AP1 - RPL23AP97, excluding RPL23AP9 and RPL23AP13.

References

1. GRCh38: Ensembl release 89: ENSG00000198242 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058546 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fan W, Christensen M, Eichler E, Zhang X, Lennon G (Feb 1998). "Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene". Genomics. 46 (2): 234–9. doi:10.1006/geno.1997.5038. PMID   9417910.
6. "Entrez Gene: RPL23A ribosomal protein L23a".
7. Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S (2014). "Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease". Science. 346 (6207): 363–8. Bibcode:2014Sci...346..363I. doi:10.1126/science.1259077. PMC   5554397 . PMID   25324392.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID   8722009.
• Fan W, Cai W, Parimoo S, Schwarz DC, Lennon GG, Weissman SM (1996). "Identification of seven new human MHC class I region genes around the HLA-F locus". Immunogenetics. 44 (2): 97–103. doi:10.1007/BF02660056. PMID   8662070. S2CID   21628804.
• Jiang H, Lin JJ, Tao J, Fisher PB (1997). "Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta". Oncogene. 14 (4): 473–80. doi: 10.1038/sj.onc.1200858 . PMID   9053844.
• Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". EMBO J. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMC   1170780 . PMID   9687515.
• Rogan S, Heaphy S (2001). "The vaccinia virus E3L protein interacts with SUMO-1 and ribosomal protein L23a in a yeast two hybrid assay". Virus Genes. 21 (3): 193–5. doi: 10.1023/A:1008139514123 . PMID   11129635. S2CID   8941317.
• Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID   11401437.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L23a