RPL23A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | RPL23A , L23A, MDA20, ribosomal protein L23a | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602326 HomoloGene: 133569 GeneCards: RPL23A | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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60S ribosomal protein L23a is a protein that in humans is encoded by the RPL23A gene. [3] [4]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [4]
L23a has been identified as an autoimmune target that causes a form of rheumatoid arthritis in mice and which also causes a reaction from T cells and autoantibodies from human rheumatoid arthritis patients. [5]
60S ribosomal protein L5 is a protein that in humans is encoded by the RPL5 gene.
60S acidic ribosomal protein P0 is a protein that in humans is encoded by the RPLP0 gene.
60S ribosomal protein L10 is a protein that in humans is encoded by the RPL10 gene.
60S ribosomal protein L7a is a protein that in humans is encoded by the RPL7A gene.
40S ribosomal protein S3 is a protein that in humans is encoded by the RPS3 gene.
40S ribosomal protein S4, X isoform is a protein that in humans is encoded by the RPS4X gene.
Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.
60S ribosomal protein L11 is a protein that in humans is encoded by the RPL11 gene.
60S ribosomal protein L4 is a protein that in humans is encoded by the RPL4 gene.
60S ribosomal protein L14 is a protein that in humans is encoded by the RPL14 gene.
60S ribosomal protein L18a is a protein that in humans is encoded by the RPL18A gene.
40S ribosomal protein S4, Y isoform 1 is a protein that in humans is encoded by the RPS4Y1 gene.
60S ribosomal protein L12 is a protein that in humans is encoded by the RPL12 gene.
40S ribosomal protein S5 is a ribosomal subunit of the Eukaryotic ribosome (80S) complex. In humans it is encoded by the RPS5 gene.
60S ribosomal protein L23 is a protein that in humans is encoded by the RPL23 gene.
60S ribosomal protein L13a is a protein that in humans is encoded by the RPL13A gene.
60S ribosomal protein L19 is a protein that in humans is encoded by the RPL19 gene.
40S ribosomal protein S7 is a protein that in humans is encoded by the RPS7 gene.
60S ribosomal protein L13 is a protein that in humans is encoded by the RPL13 gene.
60S ribosomal protein L26 is a protein that in humans is encoded by the RPL26 gene.