ATP5G1

Last updated
ATP5MC1
Identifiers
Aliases ATP5MC1 , ATP5A, ATP5G, ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9), ATP synthase membrane subunit c locus 1, ATP5G1
External IDs OMIM: 603192 MGI: 107653 HomoloGene: 38017 GeneCards: ATP5MC1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005175
NM_001002027

NM_001161419
NM_007506

RefSeq (protein)

NP_001002027
NP_005166

NP_001154891
NP_031532

Location (UCSC) Chr 17: 48.89 – 48.9 Mb Chr 11: 95.96 – 95.97 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The ATP5MC1 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase. [5] [6]

Contents

Function

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified. [6]

Related Research Articles

<span class="mw-page-title-main">MT-ATP8</span> Mitochondrial protein-coding gene whose product is involved in ATP synthesis

MT-ATP8 is a mitochondrial gene with the full name 'mitochondrially encoded ATP synthase membrane subunit 8' that encodes a subunit of mitochondrial ATP synthase, ATP synthase Fo subunit 8. This subunit belongs to the Fo complex of the large, transmembrane F-type ATP synthase. This enzyme, which is also known as complex V, is responsible for the final step of oxidative phosphorylation in the electron transport chain. Specifically, one segment of ATP synthase allows positively charged ions, called protons, to flow across a specialized membrane inside mitochondria. Another segment of the enzyme uses the energy created by this proton flow to convert a molecule called adenosine diphosphate (ADP) to ATP. Subunit 8 differs in sequence between Metazoa, plants and Fungi.

<span class="mw-page-title-main">ATP5PF</span> Protein-coding gene in the species Homo sapiens

ATP synthase-coupling factor 6, mitochondrial is an enzyme subunit that in humans is encoded by the ATP5PF gene.

<span class="mw-page-title-main">NNT (gene)</span>

NAD(P) transhydrogenase, mitochondrial is an enzyme that in humans is encoded by the NNT gene on chromosome 5.

<span class="mw-page-title-main">ATP5J2</span> Protein-coding gene in the species Homo sapiens

The ATP5MF gene encodes the ATP synthase subunit f, mitochondrial enzyme in humans.

<span class="mw-page-title-main">ATP5L</span> Protein-coding gene in the species Homo sapiens

ATP synthase subunit g, mitochondrial is an enzyme that in humans is encoded by the ATP5MG gene.

<span class="mw-page-title-main">ATP5C1</span>

The human ATP5F1C gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase.

<span class="mw-page-title-main">ATP5F1</span> Protein-coding gene in the species Homo sapiens

ATP synthase subunit b, mitochondrial is an enzyme that in humans is encoded by the ATP5PB gene.

<span class="mw-page-title-main">ATP5S</span> Protein-coding gene in the species Homo sapiens

ATP synthase subunit s, mitochondrial is an enzyme that in humans is encoded by the ATP5S gene.

<span class="mw-page-title-main">ATP5G2</span> Protein-coding gene in the species Homo sapiens

The ATP5MC2 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.

<span class="mw-page-title-main">ATP5I</span> Protein-coding gene in the species Homo sapiens

ATP synthase subunit e, mitochondrial is an enzyme that in humans is encoded by the ATP5ME gene.

<span class="mw-page-title-main">ATP5H</span> Protein-coding gene in the species Homo sapiens

The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.

<span class="mw-page-title-main">Mitochondrial ribosomal protein L15</span> Protein-coding gene in the species Homo sapiens

39S ribosomal protein L15, mitochondrial is a protein that in humans is encoded by the MRPL15 gene.

<span class="mw-page-title-main">NDUFC2</span>

NADH dehydrogenase [ubiquinone] 1 subunit C2 is an enzyme that in humans is encoded by the NDUFC2 gene.

<span class="mw-page-title-main">ATP5G3</span>

The ATP5MC3 gene is one of three human paralogs that encode membrane subunit c of the mitochondrial ATP synthase.

<span class="mw-page-title-main">ATP5PO</span> Protein-coding gene in the species Homo sapiens

ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5PO gene.

<span class="mw-page-title-main">FOXRED1</span>

FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1), also known as H17, or FP634 is an enzyme that in humans is encoded by the FOXRED1 gene. FOXRED1 is an oxidoreductase and complex I-specific molecular chaperone involved in the assembly and stabilization of NADH dehydrogenase (ubiquinone) also known as complex I, which is located in the mitochondrial inner membrane and is the largest of the five complexes of the electron transport chain. Mutations in FOXRED1 have been associated with Leigh syndrome and infantile-onset mitochondrial encephalopathy.

<span class="mw-page-title-main">SYT13</span>

Synaptotagmin-13 is a protein that in humans is encoded by the SYT13 gene.

<span class="mw-page-title-main">TOMM40L</span> Protein-coding gene in the species Homo sapiens

Mitochondrial import receptor subunit TOM40B is a protein that in humans is encoded by the TOMM40L gene.

<span class="mw-page-title-main">ATPAF2</span> Protein-coding gene in the species Homo sapiens

ATP synthase mitochondrial F1 complex assembly factor 2 is an enzyme that in humans is encoded by the ATPAF2 gene.

<span class="mw-page-title-main">Mitochondrial pyruvate carrier 2</span> Protein-coding gene in the species Homo sapiens

Mitochondrial pyruvate carrier 2 (MPC2) also known as brain protein 44 (BRP44) is a protein that in humans is encoded by the MPC2 gene. It is part of the Mitochondrial Pyruvate Carrier (MPC) protein family. This protein is involved in transport of pyruvate across the inner membrane of mitochondria in preparation for the pyruvate dehydrogenase reaction.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000159199 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000006057 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dyer MR, Walker JE (Jul 1993). "Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase". The Biochemical Journal. 293 (Pt 1): 51–64. doi:10.1042/bj2930051. PMC   1134319 . PMID   8328972.
  6. 1 2 "Entrez Gene: ATP5MC1 ATP synthase membrane subunit c locus 1".

Further reading