Suzuki in 2010
|Alma mater||Hokkaidō University|
|Known for||Suzuki reaction|
|Awards|| Nobel Prize for Chemistry (2010)|
Person of Cultural Merit (2010)
Order of Culture (2010)
|Institutions|| Hokkaidō University |
University of Wales
Okayama University of Science
Kurashiki University of Science and the Arts
|Influences||Herbert Charles Brown|
Akira Suzuki (鈴木 章, Suzuki Akira, born September 12, 1930) is a Japanese chemist and Nobel Prize Laureate (2010), who first published the Suzuki reaction, the organic reaction of an aryl- or vinyl-boronic acid with an aryl- or vinyl-halide catalyzed by a palladium(0) complex, in 1979.
Suzuki was born on September 12, 1930, in Mukawa, Hokkaidō, his father died when he was in high school. He studied chemistry at Hokkaido University (Hokudai) and after receiving his PhD while he worked there as assistant professor. He initially wanted to major in mathematics, his favorite subject in childhood was arithmetic.It was an encounter with two books became an opportunity to advance to the path of organic synthesis, one is Textbook of Organic Chemistry written by Louis Fieser of Harvard University, and another is Hydroboration written by Herbert C. Brown of Purdue University.
From 1963 until 1965, Suzuki worked as a postdoctoral student with Herbert C. Brown at Purdue University and after returning to the Hokudai he became a full professor there. The postdoctoral experience was utilized in the study of the coupling reaction with his assistant Norio Miyaura and led to the discovery of Suzuki reaction announced in 1979.Its organic boronic acids with aryl and vinyl group are stable to water and air, easy to handle, and because the conditions required for use are also relatively mild, even among the several cross-coupling techniques, it is said to be easy to use. Its full mechanism is shown in the image below.
With his retirement from Hokudai in 1994 he took several positions in other universities: 1994–1995 Okayama University of Science and 1995–2002 Kurashiki University of Science and the Arts.In addition, he was an invited professor at Purdue University (2001), Academic Sinica and the National Taiwan University (2002).
In 2010, Suzuki was jointly awarded the Nobel Prize for Chemistry together with Richard F. Heck and Ei-ichi Negishi.
To celebrate International Year of Chemistry (IYC 2011), Suzuki was interviewed by the UNESCO Courier magazine, he said：
"Today some people see chemistry just as a polluting industry, but that is a mistake......Without it, productivity would drop and we could not enjoy the life we know today. If there is pollution, it is because we are releasing harmful substances. Obviously, we have to adapt treatment and management regimes and work to develop chemical substances and manufacturing processes that respect the environment."
In 2014, a Canadian-Chinese student asked for Suzuki's advice: "how can I become a great chemist like you?", Suzuki answered him: "...above all else, you must learn to see through the appearance to perceive the essence."
Suzuki has not obtained a patent on Suzuki reaction technology because he thinks that the research was supported by government funds,therefore coupling technology has become widespread, and many products using this technology have been put into practical use. To date, there are more than 6,000 papers and patents related to Suzuki reaction.
The Heck reaction is the chemical reaction of an unsaturated halide with an alkene in the presence of a base and a palladium catalyst to form a substituted alkene. It is named after Tsutomu Mizoroki and Richard F. Heck. Heck was awarded the 2010 Nobel Prize in Chemistry, which he shared with Ei-ichi Negishi and Akira Suzuki, for the discovery and development of this reaction. This reaction was the first example of a carbon-carbon bond-forming reaction that followed a Pd(0)/Pd(II) catalytic cycle, the same catalytic cycle that is seen in other Pd(0)-catalyzed cross-coupling reactions. The Heck reaction is a way to substitute alkenes.
The Suzuki reaction is an organic reaction, classified as a cross-coupling reaction, where the coupling partners are a boronic acid and an organohalide catalyzed by a palladium(0) complex. It was first published in 1979 by Akira Suzuki and he shared the 2010 Nobel Prize in Chemistry with Richard F. Heck and Ei-ichi Negishi for their effort for discovery and development of palladium-catalyzed cross couplings in organic synthesis. In many publications this reaction also goes by the name Suzuki–Miyaura reaction and is also referred to as the Suzuki coupling. It is widely used to synthesize poly-olefins, styrenes, and substituted biphenyls. Several reviews have been published describing advancements and the development of the Suzuki Reaction. The general scheme for the Suzuki reaction is shown below where a carbon-carbon single bond is formed by coupling an organoboron species (R1-BY2) with a halide (R2-X) using a palladium catalyst and a base.
A coupling reaction in organic chemistry is a general term for a variety of reactions where two fragments are joined together with the aid of a metal catalyst. In one important reaction type, a main group organometallic compound of the type R-M reacts with an organic halide of the type R'-X with formation of a new carbon-carbon bond in the product R-R'. The most common type of coupling reaction is the cross coupling reaction.
The Negishi coupling is a widely employed transition metal catalyzed cross-coupling reaction. The reaction couples organic halides or triflates with organozinc compounds, forming carbon-carbon bonds (c-c) in the process. A palladium (0) species is generally utilized as the metal catalyst, though nickel is sometimes used:
Ei-ichi Negishi is a Manchurian-born Japanese chemist who has spent most of his career at Purdue University in the United States. He is the Herbert C. Brown Distinguished Professor and Director of the Negishi-Brown Institute at Purdue. He is best known for his discovery of the Negishi coupling. He was awarded the 2010 Nobel Prize in Chemistry "for palladium catalyzed cross couplings in organic synthesis" jointly with Richard F. Heck and Akira Suzuki.
John Kenneth Stille was an American chemist who discovered the Stille reaction. He received B.A and M.A. degrees from the University of Arizona before serving in the Navy during the Korean War. He received his Ph.D. from the University of Illinois, where he studied under Carl Shipp Marvel. Stille began his independent career at the University of Iowa in 1957 before moving to Colorado State University in 1977.
Richard Frederick Heck was an American chemist noted for the discovery and development of the Heck reaction, which uses palladium to catalyze organic chemical reactions that couple aryl halides with alkenes. The analgesic naproxen is an example of a compound that is prepared industrially using the Heck reaction.
A cross-coupling reaction in organic chemistry is a reaction where two fragments are joined together with the aid of a metal catalyst. In one important reaction type, a main group organometallic compound of the type R-M reacts with an organic halide of the type R'-X with formation of a new carbon-carbon bond in the product R-R'. Cross-coupling reaction are a subset of coupling reactions. It is often used in arylations.
CataCXium F sulf is a water-soluble organophosphorus compound derived from fluorene. The palladium complexes of the respective phosphine show an excellent activity in various palladium-catalyzed coupling reactions, including Suzuki reactions, Sonogashira couplings and Buchwald–Hartwig reactions.
Bis(triphenylphosphine)palladium chloride is a coordination compound of palladium containing two triphenylphosphine and two chloride ligands. It is a yellow solid that is soluble in some organic solvents. It is used for palladium-catalyzed coupling reactions, e.g. the Sonogashira–Hagihara reaction. The complex is square planar. Both cis and trans isomers are known, but the cis isomer is more common. Many analogous complexes are known with different phosphine ligands.
The Ivy Bowl was an international college football game played between an American, 43-man all-star team versus a team of college all-stars from Japan. The first Epson Ivy Bowl occurred on January 8, 1989, and the final game occurred at the conclusion of the 1996 NCAA Division I-AA football season. The United States won every match-up. The wins, because they were not between two NCAA-affiliated schools and some of the years were mixed school (all-star) teams do not count toward official win-loss records.
Shunichi Suzuki was a Japanese politician and bureaucrat who served as governor of Tokyo, Japan from 1979 to 1995.
Shigeru Suzuki is a Japanese musician, songwriter and guitarist. He first became known as a member of the influential rock band Happy End, but is now a prolific session musician. As of 2006, Suzuki had contributed to 588 recordings.
Rio Suzuki is a Japanese child actress and tarento. She is famous for such TV dramas as Yae no Sakura, Ashita, Mama ga Inai and as a television personality.
In organometallic chemistry, palladium-NHC complexes are a family of organopalladium compounds in which palladium forms a coordination complex with N-Heterocyclic carbenes (NHCs). They have been investigated for applications in homogeneous catalysis, particularly cross-coupling reactions.
In organic and organometallic chemistry, dialkylbiaryl phosphine (or dialkylbiarylphosphine) ligands are phosphorus-containing supporting ligands that are used to modulate the chemical reactivity of palladium and other transition metal based catalysts. They were first described by Stephen L. Buchwald in 1998 for applications in palladium-catalyzed coupling reactions to form carbon-nitrogen and carbon-carbon bonds. Before their development, use of first- or second-generation phosphine ligands for palladium-catalyzed C-N bond-forming cross-coupling (e.g., tris(o-tolyl)phosphine and BINAP, respectively) necessitated harsh conditions, and the scope of the transformation was severely limited. The Suzuki-Miyaura and Negishi cross-coupling reactions were typically performed with Pd(PPh3)4 as catalyst and were mostly limited to aryl bromides and iodides at elevated temperatures, while the widely available aryl chlorides were unreactive. The development of new classes of ligands was needed to address these limitations.
Kōsuke Morita is a Japanese experimental nuclear physicist, known as the leader of the Japanese team that discovered element 113. He currently holds a joint appointment as a professor at Kyushu University’s Graduate School of Science and as director of the Super Heavy Element Research Group at Riken's Nishina Center for Accelerator-Based Science.
Ajai Kumar Singh is an Indian chemist and Emeritus Professor of Chemistry at IIT Delhi. Singh is known for his contribution to the development of new organochalcogen ligand family and their metal complexes for promoting carbon-carbon coupling and related transformations. Singh is an honorary member of Science Faculty of the University of Delhi.
Naomichi Suzuki is a Japanese politician who currently serves as Governor of Hokkaidō. He previously served as mayor of Yūbari city for two consecutive terms from 2011 to 2019. He had also served in Regional Sovereignty Strategy Office of Cabinet Office and as a chief of General Affairs Division in General Affairs Department at Tokyo Governor's Office.