BRAP (gene)

BRAP
Identifiers
Aliases	BRAP , BRAP2, IMP, RNF52, BRCA1 associated protein
External IDs	OMIM: 604986 MGI: 1919649 HomoloGene: 4926 GeneCards: BRAP
Gene location (Human)
Chr.	Chromosome 12 (human)
End	111,685,956 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	121,825,319 bp
RNA expression pattern
	Top expressed in
	testicle; ; Achilles tendon; ; bone marrow; ; ovary; ; gastrocnemius muscle; ; blood; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity ; zinc ion binding ; metal ion binding ; ubiquitin-protein transferase activity ; GO:0001948 protein binding ; nuclear localization sequence binding ; identical protein binding ; nucleic acid binding ; transferase activity ;
Cellular component	cytoplasm ; nuclear membrane ; ubiquitin ligase complex ; cytosol ;
Biological process	MAPK cascade ; protein ubiquitination ; negative regulation of signal transduction ; Ras protein signal transduction ;
	Sources:Amigo / QuickGO
Orthologs
	8315
	72399
	ENSG00000089234
	ENSMUSG00000029458
	Q7Z569
	Q99MP8
	NM_006768
	NM_001289543 ; NM_001289544 ; NM_028227
	NP_006759
	NP_001276472 ; NP_001276473 ; NP_082503
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 08, 2022

BRCA1 associated protein is a protein that in humans is encoded by the BRAP gene. ^[5]

Function

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008].

Related Research Articles

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Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.

14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene.

Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.

Kinesin-like protein KIF1B is a protein that in humans is encoded by the KIF1B gene.

Elongation factor 1-gamma is a protein that in humans is encoded by the EEF1G gene.

Retinoblastoma-binding protein 8 is a protein that in humans is encoded by the RBBP8 gene.

Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.

N-myc-interactor also known as N-myc and STAT interactor is a protein that in humans is encoded by the NMI gene.

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.

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LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.

Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.

Interferon-induced 35 kDa protein is a protein that in humans is encoded by the IFI35 gene.

Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000089234 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029458 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: BRCA1 associated protein" . Retrieved 2018-03-23.

Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA (January 2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature. 427 (6971): 256–60. Bibcode:2004Natur.427..256M. doi:10.1038/nature02237. PMID 14724641. S2CID 4416552.
Asada M, Ohmi K, Delia D, Enosawa S, Suzuki S, Yuo A, Suzuki H, Mizutani S (September 2004). "Brap2 functions as a cytoplasmic retention protein for p21 during monocyte differentiation". Mol. Cell. Biol. 24 (18): 8236–43. doi:10.1128/MCB.24.18.8236-8243.2004. PMC 515069 . PMID 15340083.
Chen C, Lewis RE, White MA (May 2008). "IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds". J. Biol. Chem. 283 (19): 12789–96. doi: 10.1074/jbc.M709305200 . PMC 2442335 . PMID 18332145.
Mallin EA, Pavlicek W (April 2008). "55-year-old woman with menopausal symptoms and a family history of breast cancer". Mayo Clin. Proc. 83 (4): 485–8. doi:10.4065/83.4.485. PMID 18380995.
Czyzyk J, Chen HC, Bottomly K, Flavell RA (August 2008). "p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells". J. Biol. Chem. 283 (34): 23004–15. doi: 10.1074/jbc.M804084200 . PMC 2516986 . PMID 18577512.
Keinan-Boker L, Lerner-Geva L, Kaufman B, Meirow D (October 2008). "Pregnancy-associated breast cancer". Isr. Med. Assoc. J. 10 (10): 722–7. PMID 19009954.
Chen JS, Hu HY, Zhang S, He M, Hu RM (May 2009). "Brap2 facilitates HsCdc14A Lys-63 linked ubiquitin modification". Biotechnol. Lett. 31 (5): 615–21. doi:10.1007/s10529-009-9914-7. PMID 19152073. S2CID 22550914.
Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T (March 2009). "SNPs in BRAP associated with risk of myocardial infarction in Asian populations". Nat. Genet. 41 (3): 329–33. doi:10.1038/ng.326. PMID 19198608. S2CID 27136281.
Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T (March 2009). "SNPs in BRAP associated with risk of myocardial infarction in Asian populations". Nat. Genet. 41 (3): 329–33. doi:10.1038/ng.326. PMID 19198608. S2CID 27136281.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000089234 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029458 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BRCA1 associated protein" . Retrieved 2018-03-23.

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BRAP (gene)

Contents

Function

Related Research Articles

References

Further reading