Barbara Heslop

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Barbara Heslop
Born(1925-01-26)26 January 1925
Auckland, New Zealand
Died20 December 2013(2013-12-20) (aged 88)
Dunedin, New Zealand
Nationality New Zealand
Alma mater University of Otago
Spouse(s) John Heslop
Children Helen Heslop
Scientific career
Fields Pathology, Immunology
InstitutionsUniversity of Otago
Influenced Margaret Baird

Barbara Farnsworth Heslop CBE FRSNZ (née Cupit, 26 January 1925 – 20 December 2013) was a New Zealand immunologist specialising in transplantation immunology and immunogenetics.

Contents

Biography

Born in Auckland, Heslop was educated at Epsom Girls' Grammar School from 1938 to 1941 [1] [2] and then attended the University of Otago, graduating MB ChB in 1949 [3] and MD in 1954. [4]

She married surgeon John Herbert Heslop, noted for his work on skin carcinogenesis. [5] They had two daughters: Helen, a transplant scientist; [6] and Hilary, a food specialist.

Heslop gained recognition in the medical community for both her research and her teaching, at a time when women scientists were scarce. She was made a Fellow of the Royal Australasian College of Surgeons (RACS) for services to surgical sciences in 1975. [7] In 1990, in honour of her research achievements she was appointed a Fellow of the Royal Society of New Zealand [8] mainly based on her publications on allogeneic lymphocyte cytotoxicity (a natural killer cell mediated phenomenon). The same year, she and her husband John Heslop were joint recipients of the Sir Louis Barnett Medal awarded by the RACS. [7]

In the 1991 New Year Honours, Heslop was appointed a Commander of the Order of the British Empire for services to medical education. [9]

Heslop died in Dunedin in 2013. [10]

Heslop Medal

To commemorate Heslop's work and that of her husband, John Heslop, the Heslop Medal was established by the Royal Australasian College of Surgeons in 2004 to recognise and reward outstanding contributions to the Board of Basic Surgical Education and Training and its committees. [7]

Selected publications

Related Research Articles

Hematopoietic stem cell transplantation Medical procedure to replace blood or immune stem cells

Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood. It may be autologous, allogeneic or syngeneic.

Breast augmentation surgical procedure

Breast augmentation and augmentation mammoplasty is a cosmetic surgery technique using breast-implants and fat-graft mammoplasty techniques to increase the size, change the shape, and alter the texture of the breasts of a woman. Augmentation mammoplasty is applied to correct congenital defects of the breasts and the chest wall. As an elective cosmetic surgery, primary augmentation changes the aesthetics – of size, shape, and texture – of healthy breasts.

Oral and Maxillofacial Surgery is a surgical specialty focusing on reconstructive surgery of the face, facial trauma surgery, the oral cavity, head and neck, mouth, and jaws, as well as facial cosmetic surgery. Oral and maxillofacial surgeons are trained to recognize and treat a wide spectrum of diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the oral and maxillofacial region. They are trained to treat problems such as facial deformity and misaligned jaws, tumors and cysts of the jaw, head and neck cancer, skin cancer, trauma surgery and some perform dental implant surgery and the extraction of wisdom teeth. In the United States, oral and maxillofacial surgeons are trained to administer general anesthesia and deep sedation and are licensed to do so in a hospital or office setting.

Hematopoietic stem cell Stem cells that give rise to other blood cells

Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. This process is called haematopoiesis. This process occurs in the red bone marrow, in the core of most bones. In embryonic development, the red bone marrow is derived from the layer of the embryo called the mesoderm.

Cell therapy Therapy in which cellular material is injected into a patient

Cell therapy is a therapy in which viable cells are injected, grafted or implanted into a patient in order to effectuate a medicinal effect, for example, by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or grafting stem cells to regenerate diseased tissues.

Buttock augmentation

Gluteoplasty denotes the plastic surgery and the liposuction procedures for the correction of the congenital, traumatic, and acquired defects and deformities of the buttocks and the anatomy of the gluteal region; and for the aesthetic enhancement of the contour of the buttocks.

Bone grafting Bone transplant

Bone grafting is a surgical procedure that replaces missing bone in order to repair bone fractures that are extremely complex, pose a significant health risk to the patient, or fail to heal properly. Some kind of small or acute fractures can be cured but the risk is greater for large fractures like compound fractures.

Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. As of 2016, the only established therapy using stem cells is hematopoietic stem cell transplantation (HSCT). This usually takes the form of a bone marrow transplantation, but the cells can also be derived from umbilical cord blood. Research is underway to develop various sources for stem cells as well as to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes and heart disease.

Michael Woodruff English surgeon and biologist; transplantation and cancer researcher

Sir Michael Francis Addison Woodruff, FRS, FRSE FRCS was an English surgeon and scientist principally remembered for his research into organ transplantation. Though born in London, Woodruff spent his youth in Australia, where he earned degrees in electrical engineering and medicine. Having completed his studies shortly after the outbreak of World War II, he joined the Australian Army Medical Corps, but was soon captured by Japanese forces and imprisoned in the Changi Prison Camp. While there, he devised an ingenious method of extracting nutrients from agricultural wastes to prevent malnutrition among his fellow POWs.

Articular cartilage, most notably that which is found in the knee joint, is generally characterized by very low friction, high wear resistance, and poor regenerative qualities. It is responsible for much of the compressive resistance and load bearing qualities of the knee joint and, without it, walking is painful to impossible. Osteoarthritis is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably, pain. Due to a combination of acute stress and chronic fatigue, osteoarthritis directly manifests itself in a wearing away of the articular surface and, in extreme cases, bone can be exposed in the joint. Some additional examples of cartilage failure mechanisms include cellular matrix linkage rupture, chondrocyte protein synthesis inhibition, and chondrocyte apoptosis. There are several different repair options available for cartilage damage or failure.

Hepatosplenic T-cell lymphoma is a rare and generally incurable form of lymphoma, except in the case of an Allogenic Stem Cell Transplant. Hepatosplenic T-cell lymphoma is a systemic neoplasm comprising medium-sized cytotoxic T-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow.

Peripheral stem cell transplantation

Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood-forming stem cells destroyed, for example, by cancer treatment. PBSCT is now a much more common procedure than its bone marrow harvest equivalent, this is in-part due to the ease and less invasive nature of the procedure. Studies suggest that PBSCT has a better outcome in terms of the number of hematopoietic stem cell yield.

The aim of an articular cartilage repair treatment is to restore the surface of an articular joint's hyaline cartilage. Over the last decades, surgeons and researchers have been working hard to elaborate surgical cartilage repair interventions. Though these solutions do not perfectly restore articular cartilage, some of the latest technologies start to bring very promising results in repairing cartilage from traumatic injuries or chondropathies. These treatments are especially targeted by patients who suffer from articular cartilage damage. They provide pain relief while at the same time slowing down the progression of damage or considerably delaying joint replacement surgery. Articular cartilage repair treatments help patients to return to their original lifestyle; regaining mobility, going back to work and even practicing sports again.

Transplantable organs and tissues may both refer to organs and tissues that are relatively often or routinely transplanted, as well as relatively seldom transplanted organs and tissues and ones on the experimental stage.

Cartilage repair techniques are the current focus of large amounts of research. Many different strategies have been proposed as solutions for cartilage defects. Surgical techniques currently being studied include:

Haematopoietic system

The haematopoietic system is the system in the body involved in the creation of the cells of blood.

Helen Elisabeth Heslop is a physician-scientist from New Zealand whose clinical interests are in hematopoietic stem cell transplants. Heslop’s research interests are in immunotherapy to treat viral infections post transplant and hematologic malignancies. She is a professor in the Department of Medicine and Pediatrics at Baylor College of Medicine and the director of the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children’s Hospital and Houston Methodist Hospital. She is also the Dan L. Duncan Chair and the associate director of clinical research at the Dan L. Duncan Cancer Center.

Ross Ewen Beever was a New Zealand geneticist and mycologist.

John Herbert Heslop was a New Zealand surgeon noted for his treatment of burns. He was also active as a sports—particularly cricket—administrator, serving as president of the New Zealand Cricket Council from 1987 to 1989.

Shimon Slavin

Shimon Slavin, M.D., is an Israeli professor of medicine. Slavin pioneered the use of immunotherapy mediated by allogeneic donor lymphocytes and innovative methods for stem cell transplantation for the cure of hematological malignancies and solid tumors, and using hematopoietic stem cells for induction of transplantation tolerance to bone marrow and donor allografts.

References

  1. "Scholarships won". Auckland Star. 26 March 1942. p. 8. Retrieved 6 March 2014.
  2. "Obituaries" (PDF). Newsletter. Epsom Girls Grammar School Old Girls Association: 11. July 2014. Archived from the original (PDF) on 14 January 2015. Retrieved 6 August 2014.
  3. "NZ university graduates 1870–1961: Co–Cu". shadowsoftime.co.nz/. Retrieved 6 August 2014.
  4. "NZ university graduates 1870–1961: Ha–He". shadowsoftime.co.nz/. Retrieved 6 August 2014.
  5. "Heslop, John Herbert and Heslop Barbara". thecommunityarchive.org.nz/. National Register of Archives and Manuscripts. 1 August 2012. Retrieved 6 March 2014.
  6. "Alert Newsletter: Issue 153". royalsociety.org.nz/. Royal Society of New Zealand. 9 November 2000. Retrieved 6 March 2014.
  7. 1 2 3 "Heslop Medal" (PDF). surgeons.org/. Royal Australasian College of Surgeons. February 2008. Archived from the original (PDF) on 4 March 2014. Retrieved 6 March 2014.
  8. "Current Fellows « Fellowship « The Academy « Our Organisation « Royal Society of New Zealand". Royalsociety.org.nz. Retrieved 4 March 2014.
  9. "No. 52383". The London Gazette (Supplement). 31 December 1990. p. 30.
  10. "Cemeteries search – Dunedin City Council". www.dunedin.govt.nz/. Dunedin City Council. Retrieved 6 March 2014.