CD121

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Interleukins (ILs) are a group of cytokines that were first seen to be expressed by white blood cells (leukocytes). ILs can be divided into four major groups based on distinguishing structural features. However, their amino acid sequence similarity is rather weak. The human genome encodes more than 50 interleukins and related proteins.

Interleukin 10 protein-coding gene in the species Homo sapiens

Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively.

Interleukin 2 protein-coding gene in the species Homo sapiens

Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15,5 - 16 kDa protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes. The major sources of IL-2 are activated CD4+ T cells, activated CD8+ T cells, NK cells, dendritic cells and macrophages.

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Interleukin 6 protein-coding gene in the species Homo sapiens

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene.

Common gamma chain protein-coding gene in the species Homo sapiens

The common gamma chainc), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. The γc glycoprotein is a member of the type I cytokine receptor family expressed on most lymphocyte populations, and its gene is found on the X-chromosome of mammals.

Interleukin 22 protein-coding gene in the species Homo sapiens

Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene.

Interleukin 1 receptor antagonist protein-coding gene in the species Homo sapiens

The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene.

Interleukin-6 receptor protein-coding gene in the species Homo sapiens

Interleukin 6 receptor (IL6R) also known as CD126 is a type I cytokine receptor.

Interleukin 1 receptor, type II protein-coding gene in the species Homo sapiens

Interleukin 1 receptor, type II (IL-1R2) also known as CD121b is an interleukin receptor. IL1R2 also denotes its human gene.

Interleukin 10 receptor, alpha subunit protein-coding gene in the species Homo sapiens

Interleukin 10 receptor, alpha subunit is a subunit for the interleukin-10 receptor. IL10RA, is its human gene.

Interleukin 1 receptor, type I protein-coding gene in the species Homo sapiens

Interleukin 1 receptor, type I (IL1R1) also known as CD121a, is an interleukin receptor. IL1R1 also denotes its human gene.

Interleukin 12 receptor, beta 1 subunit protein-coding gene in the species Homo sapiens

Interleukin-12 receptor, beta 1, or IL-12Rβ1 in short, is a subunit of the interleukin 12 receptor. IL12RB1, is the name of its human gene. IL-12Rβ1 is also known as CD212.

Interleukin 13 receptor, alpha 1 protein-coding gene in the species Homo sapiens

Interleukin 13 receptor, alpha 1, also known as IL13RA1 and CD213A1, is a human gene.

Interleukin-9 receptor protein-coding gene in the species Homo sapiens

Interleukin 9 receptor (IL9R) also known as CD129 is a type I cytokine receptor. IL9R also denotes its human gene.

IL36G protein-coding gene in the species Homo sapiens

Interleukin-36 gamma previously known as interleukin-1 family member 9 (IL1F9) is a protein that in humans is encoded by the IL36G gene.

IL1RL2 protein-coding gene in the species Homo sapiens

Interleukin-1 receptor-like 2 is a protein that in humans is encoded by the IL1RL2 gene.

IL18R1 protein-coding gene in the species Homo sapiens

The interleukin-18 receptor 1 (IL-18R1) is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is its human gene. IL18R1 is also known as CDw218a.

Interleukin 23 heterodimeric cytokine acting as mediator of inflammation

Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an IL12B (IL-12p40) subunit and the IL23A (IL-23p19) subunit. A functional receptor for IL-23 has been identified and is composed of IL-12R β1 and IL-23R.