CHRNA3

Last updated
CHRNA3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CHRNA3 , LNCR2, NACHRA3, PAOD2, cholinergic receptor nicotinic alpha 3 subunit
External IDs MGI: 87887 HomoloGene: 591 GeneCards: CHRNA3
Gene location (Human)
Ideogram human chromosome 15.svg
Chr. Chromosome 15 (human) [1]
Human chromosome 15 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 15q25.1Start78,593,052 bp [1]
End78,621,295 bp [1]
RNA expression pattern
PBB GE CHRNA3 211587 x at fs.png

PBB GE CHRNA3 211772 x at fs.png

PBB GE CHRNA3 210221 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000743
NM_001166694

NM_145129

RefSeq (protein)

NP_000734
NP_001160166

NP_660111

Location (UCSC) Chr 15: 78.59 – 78.62 Mb Chr 9: 55.01 – 55.03 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-3, also known as nAChRα3, is a protein that in humans is encoded by the CHRNA3 gene. [5] [6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Protein biological molecule consisting of chains of amino acid residues

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific three-dimensional structure that determines its activity.

Gene basic physical and functional unit of heredity

In biology, a gene is a sequence of nucleotides in DNA or RNA that codes for a molecule that has a function. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic trait. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes as well as gene–environment interactions. Some genetic traits are instantly visible, such as eye color or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that constitute life.

Nicotinic acetylcholine receptor chemical compound

Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs, including the nicotinic receptor agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms, including humans. At the neuromuscular junction they are the primary receptor in muscle for motor nerve-muscle communication that controls muscle contraction. In the peripheral nervous system: (1) they transmit outgoing signals from the presynaptic to the postsynaptic cells within the sympathetic and parasympathetic nervous system, and (2) they are the receptors found on skeletal muscle that receive acetylcholine released to signal for muscular contraction. In the immune system, nAChRs regulate inflammatory processes and signal through distinct intracellular pathways. In insects, the cholinergic system is limited to the central nervous system.

Contents

Interactive pathway map

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|{{{bSize}}}px|alt=Nicotine Activity on Chromaffin Cells edit]]
Nicotine Activity on Chromaffin Cells edit
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    |{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
    Nicotine Activity on Dopaminergic Neurons edit

      See also

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      References

      1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000080644 - Ensembl, May 2017
      2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032303 - Ensembl, May 2017
      3. "Human PubMed Reference:".
      4. "Mouse PubMed Reference:".
      5. Eng CM, Kozak CA, Beaudet AL, Zoghbi HY (Apr 1991). "Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse". Genomics. 9 (2): 278–82. doi:10.1016/0888-7543(91)90253-B. PMID   2004777.
      6. "Entrez Gene: CHRNA3 cholinergic receptor, nicotinic, alpha 3".

      Further reading

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      This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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