Carol V. Robinson

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Carol V. Robinson

Carol Vivien Bradley

(1956-04-10) 10 April 1956 (age 65) [1]
Alma mater
Scientific career
Thesis Structural studies on bioactive organic compounds  (1982)

Dame Carol Vivien Robinson, DBE FRS FMedSci [8] (née Bradley, born 10 April 1956 [1] ) is a British chemist and former President of the Royal Society of Chemistry (2018 - 2020). [9] She is a Royal Society Research Professor at the Physical and Theoretical Chemistry Laboratory at the University of Oxford, as well as the Dr Lee's Professor of Physical and Theoretical Chemistry, and a Professorial Fellow at Exeter College. She was previously Professor of Mass Spectrometry at the Department of Chemistry of the University of Cambridge. [7] [10] [11] [12] [13]


Early life and education

Born in Kent, the daughter of Denis E. Bradley and Lillian (née Holder), [14] Carol Vivien Bradley left school at 16 and began her career as a lab technician in Sandwich, Kent with Pfizer, where she began working with the then novel technique of mass spectrometry. [15]

Her potential was spotted, and she gained further qualifications at evening classes and day release from her job at Pfizer. After earning her degree, she left Pfizer and studied for a Master of Science degree at the University of Swansea, followed by a PhD at the University of Cambridge, [16] which she completed in just two years, rather than the more usual three. [10] During this time she was a student at Churchill College, Cambridge. [1]

Career and research

After a postdoctoral training fellowship at the University of Bristol, [17] Robinson took up a junior position in the mass spectrometry unit at the University of Oxford, where she began analysing protein folding. [18] Robinson and colleagues successfully captured protein folding in the presence of the chaperone GroEL, demonstrating that at least some aspects of protein secondary structure could be studied in the gas phase.

Robinson has broken ground as the first female professor in the department of chemistry at both the University of Cambridge (2001) and the University of Oxford (2009). [19] Her research has pushed the limits of electrospray ionization mass spectrometry, demonstrating that proteins and other complex macromolecules can be studied in the gas phase. [20] In addition to her contributions to the study of protein folding, Robinson has conducted important work on ribosomes, molecular chaperones and most recently membrane proteins. [21] [22] [23] [24] Her research has made seminal contributions to gas-phase structural biology, with progress toward the study of protein complexes in their native environments for drug discovery. [25] Additionally, she is Co-founder and director of OMass Therapeutics, a University of Oxford spin-out company applying mass spectrometry technology to drug discovery. [26]

Honours and awards

Robinson was awarded the American Society for Mass Spectrometry's Biemann Medal in 2003, and the Christian B. Anfinsen Award in 2008. In 2004 the Royal Society awarded her both a Fellowship (FRS) [8] and the Rosalind Franklin Award. [27] Her nomination for the Royal Society reads: [8]

Distinguished for her research on the application of mass spectrometry to problems in chemical biology. She has used mass spectrometry to define the folding and binding of interacting proteins in large complexes. Most importantly, she has established that macromolecular complexes such as GroEL, ribosomes, and intact virus capsids can be generated in the gas phase and their electrospray mass spectra recorded. This work has demonstrated the power of mass spectrometry in studying very large complexes and allowed her to define changes in their conformation and the manner of their assembly.

In 2010 Robinson received the Davy Medal "for her ground-breaking and novel use of mass spectrometry for the characterisation of large protein complexes". [28] [29]

In 2011 she was given the Interdisciplinary Prize by the Royal Society of Chemistry for "development of a new area of research, gas-phase structural biology, using highly refined mass spectrometry techniques", [30] the Aston Medal, and the FEBS/EMBO Women in Science Award.

She has been awarded honorary doctorates from the University of Kent, the University of York, and the University of Bristol. [31]

She was appointed Dame Commander of the Order of the British Empire (DBE) in the 2013 New Year Honours for services to science and industry. [32]

She received the Thomson Medal Award in 2014. [33]

In 2015 she was a laureate of the L'Oréal-UNESCO For Women in Science Awards; "For her groundbreaking work in macromolecular mass spectrometry and pioneering gas phase structural biology by probing the structure and reactivity of single proteins and protein complexes, including membrane proteins." [34] She was also made a Rhodes Trustee. [35]

In 2017 she was elected a Foreign Associate of the US National Academy of Sciences. [36]

In 2018 she won the Frank H. Field and Joe L. Franklin Award for Outstanding Achievement in Mass Spectrometry from the American Chemical Society. [37]

In 2019 she won the Novozymes Prize for "almost single-handedly founding a subfield of mass spectrometry proteomics". [38] Also in 2019 she received the Royal Medal. [39]

In 2020, she was chosen as the recipient of the Othmer Gold Medal. [40]

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  1. 1 2 3 4 Anon (2015) "ROBINSON, Dame Carol Vivien". Who's Who . A & C Black, an imprint of Bloomsbury Publishing plc.(subscription or UK public library membership required) doi : 10.1093/ww/9780199540884.013.U4000698 (subscription required)
  2. Tan, X; Calderon-Villalobos, L. I.; Sharon, M; Zheng, C; Robinson, C. V.; Estelle, M; Zheng, N (2007). "Mechanism of auxin perception by the TIR1 ubiquitin ligase". Nature. 446 (7136): 640–5. Bibcode:2007Natur.446..640T. doi:10.1038/nature05731. PMID   17410169. S2CID   4338917.
  3. Booth, D. R.; Sunde, M; Bellotti, V; Robinson, C. V.; Hutchinson, W. L.; Fraser, P. E.; Hawkins, P. N.; Dobson, C. M.; Radford, S. E.; Blake, C. C.; Pepys, M. B. (1997). "Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis". Nature. 385 (6619): 787–93. Bibcode:1997Natur.385..787B. doi:10.1038/385787a0. PMID   9039909. S2CID   4347837.
  4. Jiménez, J. L.; Nettleton, E. J.; Bouchard, M; Robinson, C. V.; Dobson, C. M.; Saibil, H. R. (2002). "The protofilament structure of insulin amyloid fibrils". Proceedings of the National Academy of Sciences of the United States of America. 99 (14): 9196–201. Bibcode:2002PNAS...99.9196J. doi:10.1073/pnas.142459399. PMC   123117 . PMID   12093917.
  5. Pepys, M. B.; Hirschfield, G. M.; Tennent, G. A.; Gallimore, J.; Kahan, M. C.; Bellotti, V.; Hawkins, P. N.; Myers, R. M.; Smith, M. D.; Polara, A.; Cobb, A. J. A.; Ley, S. V.; Aquilina, J.; Robinson, C. V.; Sharif, I.; Gray, G. A.; Sabin, C. A.; Jenvey, M. C.; Kolstoe, S. E.; Thompson, D.; Wood, S. P. (2006). "Targeting C-reactive protein for the treatment of cardiovascular disease". Nature. 440 (7088): 1217–1221. Bibcode:2006Natur.440.1217P. doi:10.1038/nature04672. PMID   16642000. S2CID   4324584.
  6. Miranker, A; Robinson, C. V.; Radford, S. E.; Aplin, R. T.; Dobson, C. M. (1993). "Detection of transient protein folding populations by mass spectrometry". Science. 262 (5135): 896–900. Bibcode:1993Sci...262..896M. doi:10.1126/science.8235611. PMID   8235611.
  7. 1 2 Pain, Elisabeth (2011). "An Interview with Carol Robinson". Science. doi:10.1126/science.caredit.a1100023.
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  9. "Carol Robinson | Royal Society". Retrieved 4 August 2019.
  10. 1 2 Al-Khalili, Jim (2014). "Carol Robinson interviewed on The Life Scientific". BBC.
  11. Robinson, C. V. (2011). "Women in science: In pursuit of female chemists". Nature. 476 (7360): 273–5. Bibcode:2011Natur.476..273R. doi: 10.1038/476273a . PMID   21850083. S2CID   205066711.
  12. Carol V. Robinson publications indexed by the Scopus bibliographic database. (subscription required)
  13. Carol Robinson's Official website OOjs UI icon edit-ltr-progressive.svg
  14. "Births June 1956: Index entry". FreeBMD. ONS. Retrieved 23 July 2014.
  15. Sullivan, Ruth (12 December 2014). "Dame Carol Robinson: from school leaver at 16 to leading chemist". Financial Times. ISSN   0307-1766 . Retrieved 5 August 2016.
  16. Bradley, Carol Vivien (1982). Structural studies on bioactive organic compounds. (PhD thesis). University of Cambridge. EThOS
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  20. "Carol Robinson". Retrieved 24 November 2017.
  21. Hall, Z; Hernández, H; Marsh, J. A.; Teichmann, S. A.; Robinson, C. V. (2013). "The role of salt bridges, charge density, and subunit flexibility in determining disassembly routes of protein complexes". Structure. 21 (8): 1325–37. doi:10.1016/j.str.2013.06.004. PMC   3737473 . PMID   23850452.
  22. Marsh, J. A.; Hernández, H; Hall, Z; Ahnert, S. E.; Perica, T; Robinson, C. V.; Teichmann, S. A. (2013). "Protein complexes are under evolutionary selection to assemble via ordered pathways". Cell. 153 (2): 461–70. doi:10.1016/j.cell.2013.02.044. PMC   4009401 . PMID   23582331.
  23. Levy, E. D.; Boeri Erba, E; Robinson, C. V.; Teichmann, S. A. (2008). "Assembly reflects evolution of protein complexes". Nature . 453 (7199): 1262–5. Bibcode:2008Natur.453.1262L. doi:10.1038/nature06942. PMC   2658002 . PMID   18563089.
  24. Ruotolo, B. T. (2005). "Evidence for Macromolecular Protein Rings in the Absence of Bulk Water". Science. 310 (5754): 1658–1661. Bibcode:2005Sci...310.1658R. doi:10.1126/science.1120177. PMID   16293722. S2CID   37135092.
  25. Viegas, Jennifer (16 April 2019). "Profile of Dame Carol Robinson". Proceedings of the National Academy of Sciences. 116 (16): 7608–7610. doi:10.1073/pnas.1903862116. ISSN   0027-8424. PMC   6475430 . PMID   30936318.
  26. "Get to know About Us". OMass. Retrieved 7 March 2020.
  27. "Finding the right balance: from rare gases to ribosomes". Archived from the original on 10 August 2014.
  28. "The Davy Medal (1877)". The Royal Society. Archived from the original on 16 March 2015.
  29. Loo, J. A.; Gross, M. L. (2004). "Focus in honor of Carol V. Robinson, 2003 Biemann Medal awardee". Journal of the American Society for Mass Spectrometry. 15 (10): 1379–1381. doi: 10.1016/j.jasms.2004.07.011 . PMID   15465349.
  30. "Interdisciplinary Prize 2011 Winner".
  31. "Carol Robinson awards". University of Oxford. Archived from the original on 5 March 2014.
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  33. "The 2014 Thomson Medal Award IMSC 2014" . Retrieved 8 April 2014.
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  39. Royal Medal 2019
  40. "Othmer Gold Medal". Science History Institute. 31 May 2016. Retrieved 1 February 2018.