Cicloprolol

Last updated
Cicloprolol
Cicloprolol.svg
Names
IUPAC name
1-[4-[2-(Cyclopropylmethoxy)ethoxy]phenoxy]-3-(propan-2-ylamino)propan-2-ol
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
KEGG
PubChem CID
UNII
  • InChI=1S/C18H29NO4/c1-14(2)19-11-16(20)13-23-18-7-5-17(6-8-18)22-10-9-21-12-15-3-4-15/h5-8,14-16,19-20H,3-4,9-13H2,1-2H3
    Key: JNDJPKHYZWRRIS-UHFFFAOYSA-N
  • CC(C)NCC(COC1=CC=C(C=C1)OCCOCC2CC2)O
Properties
C18H29NO4
Molar mass 323.433 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Cicloprolol is a beta-adrenoceptor antagonist. [1]

Synthesis

Cicloprolol synthesis: Cicloprolol synthesis.svg
Cicloprolol synthesis:

See also

Related Research Articles

In a chemical reaction, chemical equilibrium is the state in which both the reactants and products are present in concentrations which have no further tendency to change with time, so that there is no observable change in the properties of the system. This state results when the forward reaction proceeds at the same rate as the reverse reaction. The reaction rates of the forward and backward reactions are generally not zero, but they are equal. Thus, there are no net changes in the concentrations of the reactants and products. Such a state is known as dynamic equilibrium.

The likelihood function describes the joint probability of the observed data as a function of the parameters of the chosen statistical model. For each specific parameter value in the parameter space, the likelihood function therefore assigns a probabilistic prediction to the observed data . Since it is essentially the product of sampling densities, the likelihood generally encapsulates both the data-generating process as well as the missing-data mechanism that produced the observed sample.

Beta Centauri Star system in the constellation of Centaurus

Beta Centauri, officially called Hadar, is a triple star system in the southern constellation of Centaurus. The system's combined apparent visual magnitude of 0.61 makes it the second-brightest object in Centaurus and one of the brightest stars in the night sky. According to parallax measurements from the astrometric Hipparcos satellite, the distance to this system is about 390 light-years.

The Ising model, , named after the physicists Ernst Ising and Wilhelm Lenz, is a mathematical model of ferromagnetism in statistical mechanics. The model consists of discrete variables that represent magnetic dipole moments of atomic "spins" that can be in one of two states. The spins are arranged in a graph, usually a lattice, allowing each spin to interact with its neighbors. Neighboring spins that agree have a lower energy than those that disagree; the system tends to the lowest energy but heat disturbs this tendency, thus creating the possibility of different structural phases. The model allows the identification of phase transitions as a simplified model of reality. The two-dimensional square-lattice Ising model is one of the simplest statistical models to show a phase transition.

Einstein field equations Field equations in general relativity

In the general theory of relativity, the Einstein field equations relate the geometry of spacetime to the distribution of matter within it.

The equilibrium constant of a chemical reaction is the value of its reaction quotient at chemical equilibrium, a state approached by a dynamic chemical system after sufficient time has elapsed at which its composition has no measurable tendency towards further change. For a given set of reaction conditions, the equilibrium constant is independent of the initial analytical concentrations of the reactant and product species in the mixture. Thus, given the initial composition of a system, known equilibrium constant values can be used to determine the composition of the system at equilibrium. However, reaction parameters like temperature, solvent, and ionic strength may all influence the value of the equilibrium constant.

Gauss–Newton algorithm

The Gauss–Newton algorithm is used to solve non-linear least squares problems. It is a modification of Newton's method for finding a minimum of a function. Unlike Newton's method, the Gauss–Newton algorithm can only be used to minimize a sum of squared function values, but it has the advantage that second derivatives, which can be challenging to compute, are not required.

The rigid rotor is a mechanical model of rotating systems. An arbitrary rigid rotor is a 3-dimensional rigid object, such as a top. To orient such an object in space requires three angles, known as Euler angles. A special rigid rotor is the linear rotor requiring only two angles to describe, for example of a diatomic molecule. More general molecules are 3-dimensional, such as water, ammonia, or methane.

Beta-secretase 2

Beta-secretase 2 is an enzyme that cleaves Glu-Val-Asn-Leu!Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein. BACE2 is a close homolog of BACE1.

In statistics, the delta method is a result concerning the approximate probability distribution for a function of an asymptotically normal statistical estimator from knowledge of the limiting variance of that estimator.

Beta Herculis Star in the northern constellation of Hercules

Beta Herculis, formally named Kornephoros, or Rutilicus, is a binary star and the brightest star in the northern constellation of Hercules at a base apparent visual magnitude of 2.81. This is a suspected variable star with an apparent magnitude that may rise as high as 2.76. Based upon parallax measurements, it is located at a distance of 139 light-years from the Sun.

Bisoprolol

Bisoprolol, marketed under the tradename Concor among others, is a beta blocker medication most commonly used for heart diseases. This specifically includes high blood pressure, chest pain from not enough blood flow to the heart, and heart failure. It is taken by mouth.

Thymopoietin

Lamina-associated polypeptide 2 (LAP2), isoforms beta/gamma is a protein that in humans is encoded by the TMPO gene. LAP2 is an inner nuclear membrane (INM) protein.

17β-Hydroxysteroid dehydrogenases, also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism. This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol.

Prenalterol

Prenalterol is a cardiac stimulant which acts as a β1 adrenoreceptor agonist.

RAR-related orphan receptor beta

RAR-related orphan receptor beta (ROR-beta), also known as NR1F2 is a nuclear receptor that in humans is encoded by the RORB gene.

HBG1

Hemoglobin subunit gamma-1 is a protein that in humans is encoded by the HBG1 gene.

Beta-3 adrenergic receptor

The beta-3 adrenergic receptor3-adrenoceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the human gene encoding it.

In nonideal fluid dynamics, the Hagen–Poiseuille equation, also known as the Hagen–Poiseuille law, Poiseuille law or Poiseuille equation, is a physical law that gives the pressure drop in an incompressible and Newtonian fluid in laminar flow flowing through a long cylindrical pipe of constant cross section. It can be successfully applied to air flow in lung alveoli, or the flow through a drinking straw or through a hypodermic needle. It was experimentally derived independently by Jean Léonard Marie Poiseuille in 1838 and Gotthilf Heinrich Ludwig Hagen, and published by Poiseuille in 1840–41 and 1846. The theoretical justification of the Poiseuille law was given by George Stokes in 1845.

Mauroniscidae is a family of soft-winged flower beetles in the order Coleoptera, formerly included in the family Melyridae. There are presently five or six genera and roughly 30 described species in Mauroniscidae.

References

  1. Cocco, G; Alfiero, R; Pouleur, H (1992). "An evaluation of the safety of the beta-modulator cicloprolol in chronic heart failure". Clinical Cardiology. 15 (1): 38–42. doi: 10.1002/clc.4960150109 . PMID   1347258.
  2. DE 2649605,Manoury, Philippe Michel Jacques; Cavero, Icilio Angelo Girolamo& Majer, Henryet al.,"Phenoläther, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimttel [Phenol ethers, processes for their preparation and medicinal products containing them]",published 1977-05-18, assigned to Synthelabo S.A.
  3. P. M. J. Manouri, I. A. G. Carero, H. Majer, and P. R. L. Giudicelli, (1977) Chem. Abstr., 87:134,543j (1977). eidem U.S. Patent 4,311,708