Sir Geoffrey Langdon Keynes ( /ˈkeɪnz/ KAYNZ; 25 March 1887, Cambridge – 5 July 1982, Cambridge) was a British surgeon and author. [2] He began his career as a physician in World War I, before becoming a doctor at St Bartholomew's Hospital in London, where he made notable innovations in the fields of blood transfusion and breast cancer surgery. Keynes was also a publishing scholar and bibliographer of English literature and English medical history, focusing primarily on William Blake and William Harvey.
Geoffrey Keynes was born on 25 March 1887 in Cambridge, England. [3] His father was John Neville Keynes, an economics lecturer at the University of Cambridge and his mother was Florence Ada Brown, a successful author and a social reformer. [3] Geoffrey Keynes was the third child, after his older brother, the prominent economist John Maynard Keynes, and his sister Margaret, who married the Nobel Prize–winning physiologist Archibald Hill.
He attended Rugby School, where he became friends with English poet Rupert Brooke. [4] In 1915 he was appointed literary executor for Brooke's estate.
He graduated from Pembroke College, Cambridge, where he earned a first-class degree in the Natural Sciences Tripos. [5] He was later made an honorary fellow of Pembroke College. [6] Keynes then qualified for a scholarship to become a surgeon with the Royal College of Surgeons in London. [3]
Keynes delayed his medical education in order to serve in World War I, where he served as a Lieutenant in the Royal Army Medical Corps and then worked as a consultant surgeon, becoming an expert in blood transfusion. [3] His experience in the First World War led him to publish Blood Transfusion, the first book on the subject written by a British author. [6] Keynes also founded the London Blood Transfusion Service with P. L. Oliver. [5] Alexander Bogdanov acquired a copy of this book whilst visiting London to negotiate the Anglo-Soviet Trade Agreement in 1922. Bogdanov went on to found the Institute for Haematology and Blood Transfusions in Moscow. [7]
Keynes was deeply affected by the brutality and gore that he witnessed in the field, which may have influenced his dislike for radical surgery later in his career.
Keynes enlisted to be a consulting surgeon to the Royal Air Force at the outbreak of World War II. In 1944 he was promoted to the rank of acting air vice-marshal. [8]
Keynes began working full-time at St Bartholomew's Hospital in London, where he worked under George Gask and Sir Thomas Dunhill, after returning from World War I. [9] Keynes used his influence as an assistant surgeon to advocate for limited surgery instead of the invasive radical mastectomy. Frustrated with the mortality rate and gruesomeness of the radical mastectomy, Keynes experimented by inserting 50 milligrams of radium in a patient's tumour. [10] He later observed that, "The ulcer rapidly healed ... and the whole mass became smaller, softer and less fixed." [11]
Keynes pursued his new idea through a number of trials, observing the effectiveness of injecting radium chloride into breast cancer tumours compared with the effectiveness of the radical mastectomy. [12] The promising results of these trials led Keynes to be cautiously optimistic, writing in 1927 that the "extension of [an] operation beyond a local removal might sometimes be unnecessary." [11] Keynes' outlook was considered a radical break from the medical consensus at the time. Keynes wrote in his autobiography that his work with radium "was regarded with some interest by American surgeons," but that the concept of a limited mastectomy failed to gain significant traction in the medical community at the time. [10] [13] His doubts regarding the radical mastectomy were vindicated some 50 years later, when innovators like Bernard Fisher and others revisited his data and pursued what became known as a lumpectomy. [10] Limited surgeries, like the lumpectomy, accompanied by radiation are now the standard treatment for breast cancer. [10]
Keynes was also a pioneer in the treatment of myasthenia gravis. [14] Much like with breast cancer, the medical community knew little about how to treat the disease at the time. Keynes pioneered the removal of the thymus gland, which is now the standard treatment for myasthenia gravis. [14]
In 1955 Keynes received a knighthood for services to medicine. [15]
Keynes maintained a passionate interest in English literature all his life and devoted a large amount of his time to literary scholarship and the science of bibliography. He was a leading authority on the literary and artistic work of William Blake. [4] He also produced biographies and bibliographies of English writers such as Sir Thomas Browne, John Evelyn, Siegfried Sassoon, John Donne and Jane Austen. He was also a pioneer in the history of science, with studies of John Ray, William Harvey and Robert Hooke. [14] His biography The Life of William Harvey was awarded the 1966 James Tait Black Memorial Prize. Keynes also collected books, with a personal library with around four thousand works. [4]
His autobiography The Gates of Memory was published in 1981, and he died the following year, aged 95. The Gates of Memory includes anecdotes of Keynes' numerous run-ins and friendships with other famous public figures. For example, Keynes often went climbing with George Mallory, the renowned British mountaineer; he also once performed life-saving treatment on Virginia Woolf after the budding author overdosed on pills. [15] [13]
On 12 May 1917 Keynes married Margaret Elizabeth Darwin, the daughter of Sir George Howard Darwin and granddaughter of Charles Darwin. They had one daughter, who died in infancy, and four sons:
Keynes dedicated his life to his work and was also sociable with many friends. He took pride in never having been drunk, and was known by most as an affable, well-mannered man. [2]
Keynes' contributions profoundly influenced the fields of surgery and English literature. He pioneered limited breast cancer surgery accompanied by radiation, a strategy that has endured the test of time. His work on William Blake "was instrumental in establishing Blake as a central figure in the history of English art and literature." [6]
A library of his scholarly works, notes, and correspondences is held by the University of Cambridge. [8]
Mastectomy is the medical term for the surgical removal of one or both breasts, partially or completely. A mastectomy is usually carried out to treat breast cancer. In some cases, women believed to be at high risk of breast cancer have the operation as a preventive measure. Alternatively, some women can choose to have a wide local excision, also known as a lumpectomy, an operation in which a small volume of breast tissue containing the tumor and a surrounding margin of healthy tissue is removed to conserve the breast. Both mastectomy and lumpectomy are referred to as "local therapies" for breast cancer, targeting the area of the tumor, as opposed to systemic therapies, such as chemotherapy, hormonal therapy, or immunotherapy.
Rupert Chawner Brooke was an English poet known for his idealistic war sonnets written during the First World War, especially "The Soldier". He was also known for his boyish good looks, which were said to have prompted the Irish poet W. B. Yeats to describe him as "the handsomest young man in England".
Gwendolen Mary "Gwen" Raverat, was an English wood engraver who was a founder member of the Society of Wood Engravers. Her memoir Period Piece was published in 1952.
Geoffrey Edward Harvey Grigson was a British poet, writer, editor, critic, exhibition curator, anthologist and naturalist. In the 1930s he was editor of the influential magazine New Verse, and went on to produce 13 collections of his own poetry, as well as compiling numerous anthologies, among many published works on subjects including art, travel and the countryside. Grigson exhibited in the London International Surrealist Exhibition at New Burlington Galleries in 1936, and in 1946 co-founded the Institute of Contemporary Arts. Grigson's autobiography The Crest on the Silver was published in 1950. At various times he was involved in teaching, journalism and broadcasting. Fiercely combative, he made many literary enemies.
Augustus Theodore (Theo) Bartholomew was a librarian at Cambridge University Library from 1900 until his death in 1933. He maintained friendships with a number of significant individuals, including Siegfried Sassoon, the novelist Forrest Reid and the uranian poet and librarian Charles Sayle. He was editor, with Henry Festing Jones, of the works of Samuel Butler and collected material for a biography of Frederick Rolfe.
Sir Astley Paston Cooper, 1st Baronet was a British surgeon and anatomist, who made contributions to otology, vascular surgery, the anatomy and pathology of the mammary glands and testicles, and the pathology and surgery of hernia.
William Stewart Halsted, M.D. was an American surgeon who emphasized strict aseptic technique during surgical procedures, was an early champion of newly discovered anesthetics, and introduced several new operations, including the radical mastectomy for breast cancer. Along with William Osler, Howard Atwood Kelly and William H. Welch, Halsted was one of the "Big Four" founding professors at the Johns Hopkins Hospital. His operating room at Johns Hopkins Hospital is in Ward G, and was described as a small room where medical discoveries and miracles took place. According to an intern who once worked in Halsted's operating room, Halsted had unique techniques, operated on the patients with great confidence and often had perfect results which astonished the interns.
Radical mastectomy is a surgical procedure involving the removal of breast, underlying chest muscle, and lymph nodes of the axilla as a treatment for breast cancer. Breast cancer is the most common cancer among women today, and used to be primarily treated by surgery, particularly during the early twentieth century when the mastectomy was developed with success. However, with the advancement of technology and surgical skills, the extent of mastectomies has been reduced. Less invasive mastectomies are employed today in comparison to those in the past. Nowadays, a combination of radiotherapy and breast conserving mastectomy are employed to optimize treatment.
Michael Sadleir, born Michael Thomas Harvey Sadler, was a British publisher, novelist, book collector, and bibliographer.
Sir John Fraser, 1st Baronet, was Regius Professor of Clinical Surgery at Edinburgh University from 1925 to 1944 and served as principal of the University of Edinburgh from 1944 to 1947.
Charles Edward Sayle was an English Uranian poet, literary scholar and librarian. He was the youngest son of Robert Sayle, a wealthy salesman, and Priscilla Caroline Sayle. He served as an under-librarian at Cambridge University Library. His works include Bertha: a story of love (1885), Wicliff: an historical drama (1887), Erotidia (1889), Musa Consolatrix (1893), Private Music (1911) and Cambridge Fragments (1913). He also edited an anthology of verse, In Praise of Music (1897) and compiled Annals of Cambridge University Library; 1278-1900 (1916). He edited the 3-volume Works of Sir Thomas Browne; volumes I & II were published in 1904 by Grant Richards in London; volume III was published in 1907 by John Grant in Edinburgh.
Surgery is the branch of medicine that deals with the physical manipulation of a bodily structure to diagnose, prevent, or cure an ailment. Ambroise Paré, a 16th-century French surgeon, stated that to perform surgery is, "To eliminate that which is superfluous, restore that which has been dislocated, separate that which has been united, join that which has been divided and repair the defects of nature."
Hon. Noël Olivier Richards was an English medical doctor. She was born on Christmas Day 1892, hence her name, as the daughter of Sydney Olivier, 1st Baron Olivier and Margaret Cox. A cousin was the actor Sir Laurence Olivier. She attended the progressive Bedales School in Petersfield, Hampshire. Later she was a member of both the Bloomsbury Group and Rupert Brooke's group of Cambridge Neopagans. For a while, she and Brooke were in a relationship.
Harold Ellis CBE FRCS is an English retired surgeon. He was Emeritus Professor of Surgery in the University of London and most recently a professor in the Department of Anatomy & Human Sciences at the King's College London School of Medicine. He qualified as a doctor from the University of Oxford in July 1948, the same month the National Health Service began. From 1950 to 1951 he undertook national service as a captain in the Royal Army Medical Corps, afterwards continuing his training as a surgical registrar in London, Sheffield and Oxford before taking up a post as senior lecturer in the University of London. In 1962, he took up the foundation chair of surgery at the Westminster Hospital, a post which he held until his retirement from practice in 1989. After a stint teaching anatomy in the University of Cambridge, he took up his present position in 1993.
Sir D'Arcy Power, was a British surgeon, medical historian, and contributor of some 200 articles on famous surgeons and other related figures to the Dictionary of National Biography.
Bernard Fisher was an American surgeon and a pioneer in the biology and treatment of breast cancer. He was a native of Pittsburgh. He was Chairman of the National Surgical Adjuvant Breast Project at the University of Pittsburgh School of Medicine. His work established definitively that early-stage breast cancer could be more effectively treated by lumpectomy, in combination with radiation therapy, chemotherapy, and/or hormonal therapy, than by radical mastectomy.
All Religions are One is a series of philosophical aphorisms by William Blake, written in 1788. Following on from his initial experiments with relief etching in the non-textual The Approach of Doom (1787), All Religions are One and There is No Natural Religion represent Blake's first successful attempt to combine image and text via relief etching, and are thus the earliest of his illuminated manuscripts. As such, they serve as a significant milestone in Blake's career; as Peter Ackroyd points out, "his newly invented form now changed the nature of his expression. It had enlarged his range; with relief etching, the words inscribed like those of God upon the tables of law, Blake could acquire a new role."
George Washington "Barney" Crile Jr. was an American surgeon. He was a significant influence on how breast cancer is treated and was a visible and controversial advocate for alternative procedures.
Joseph Colt Bloodgood was a prominent surgeon in the United States based in Johns Hopkins Hospital in Baltimore, Maryland. He was known for insisting on the use of rubber gloves by the entire surgical team, for advances in methods of identifying and treating benign and malignant cancers, particularly breast and bone cancers, and for advocating education of the public so they would seek routine medical examinations, even before any signs of cancer appeared.
Sir Gordon Gordon-Taylor CB KBE FRCS FACS was a British surgeon