Giant-cell tumor of the tendon sheath

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Giant-cell tumor of the tendon sheath
Giant cell tumor of tendon sheath histopathology(1).jpg
Histopathology of giant-cell tumor of the tendon sheath arising in hand finger. Hematoxylin and eosin stain.
Specialty Oncology, rheumatology   OOjs UI icon edit-ltr-progressive.svg

Giant-cell tumor of the tendon sheath, also known as giant-cell synovioma and localized nodular tenosynovitis, [1] is a firm lesion, measuring 1 to 3 cm in diameter, and is most commonly attached to the tendons of the fingers, hands, and wrists, with a predilection for the flexor surfaces. [1] [2] Giant-cell tumor of tendon sheaths most often affect the wrist and fingers of males and females from the ages of 20-50 . These tumors are typically painless and can cause cortical erosion. Surgery to remove the tumor is a common treatment, though there is a risk of recurrence which is related to the mitotic count [3] .

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Fibroma of tendon sheath is a benign tumor that presents as a small subcutaneous nodule that slowly increases in size. The tumors often have a multinodular growth pattern, with individual nodules being composed of bland, slender, spindle-shaped cells (myofibroblasts) in a dense, fibrous matrix.” A common microscopic finding is the presence of elongated, slit-like blood vessels. The lesions nearly always arise in the distal portions of the extremities. They often occur on the fingers, hands, toes, or feet. Although they are benign, they may recur in up to 40% of cases.

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References

  1. 1 2 Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1820. ISBN   978-1-4160-2999-1.
  2. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN   0-7216-2921-0.
  3. Linney, L. S.; Al-Hassani, F.; Pikturnaite, J.; Mathew, B.; Thornton, D.; Wade, Ryckie. G.; Pinder, Richard. M. (1 June 2019). "Tenosynovial giant cell tumours of the hand: A multicentre case-control study". Journal of Plastic, Reconstructive & Aesthetic Surgery. 72 (6): 918–923. doi:10.1016/j.bjps.2019.01.021. ISSN   1748-6815.
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