Guy Dodson

Last updated

Guy Dodson
Guy Dodson.jpg
Guy Dodson
Born
George Guy Dodson

(1937-01-13)13 January 1937
Palmerston North, New Zealand
Died24 December 2012(2012-12-24) (aged 75)
York, UK
Alma mater University of New Zealand (BSc, PhD)
Spouse(s) Eleanor Dodson [1]
Childrenfour [1]
Awards
Scientific career
Fields X-ray crystallography
Institutions
Influences Dorothy Hodgkin
Website

(George) Guy Dodson FRS FMedSci (13 January 1937 – 24 December 2012), was a biochemist who specialised in protein crystallography at the University of York. [2] [3] [4] [5] [6] [7] [8] [9]

Contents

Education

Dodson graduated from the University of New Zealand where he was awarded a Bachelor of Science and Doctor of Philosophy degrees.

Career

Dodson did postdoctoral research with Dorothy Hodgkin at the University of Oxford. [10] [11] [12] [13] He devised along with Hodgkin, very intricate experimental, crystallographic and computer techniques that led to the final solution of the structure of insulin. Dodson was head of the structural biology laboratories at the University of York and National Institute for Medical Research, London. During his career he collaborated with many scientists [9] including Dale Wigley, Gideon Davies, [4] Andrzej Brzozowski, [14] Leo Brady [15] and Max Perutz. [16]

Awards and honours

Dodson was elected a Fellow of the Royal Society (FRS) [17] in 1994. His nomination reads

Guy Dodson's major researches have been concerned with the Xray analysis of a variety of crystalline proteins many now being carried out with increasing speed and accuracy through the use of synchrotron radiation. His most considerable work, on insulin, extends from his part in the first solution of the 2 zinc insulin crystal structure to the refeinement of the atomic parameters of both protein and water moledules at 1.5A resolution. He has recently explored remarkable conformational variations of the insulin molecule under different conditions, which give rise to three different hexamers, dimers at different pH and a monomeric despentapeptide insulin. He is at present investigating structure activity relations of genetically engineered varieties of insulin. Other systems he has studied include a series of bacterial ribonucleases and the T state of haemoglobin as seen in the partially liganded T alpha oxy beta deoxy, T alpha met beta met and T alpha deoxy beta deoxy human haemoglobins, crystallised from polyethyleneglycol. It is characteristic of him that he has created a laboratory to which protein crystals are brought from all over the world and their structures solved. [18]

Dodson was also a Foreign Member of the Indian National Science Academy (ForMemINSA) and the Academy of Medical Sciences (FMedSci).

He was a recipient of the RSC Structural Chemistry Award in 1991.

Personal life

Dodson was married to the scientist Eleanor Dodson with whom he had four children. [1]

Related Research Articles

Insulin Peptide hormone

Insulin is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of glucose from the blood into liver, fat and skeletal muscle cells. In these tissues the absorbed glucose is converted into either glycogen via glycogenesis or fats (triglycerides) via lipogenesis, or, in the case of the liver, into both. Glucose production and secretion by the liver is strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into large molecules inside the cells. Low insulin levels in the blood have the opposite effect by promoting widespread catabolism, especially of reserve body fat.

Dorothy Hodgkin British chemist

Dorothy Mary Crowfoot Hodgkin was a Nobel Prize-winning British chemist who advanced the technique of X-ray crystallography to determine the structure of biomolecules, which became an essential tool in structural biology.

John Kendrew

Sir John Cowdery Kendrew, was an English biochemist, crystallographer, and science administrator. Kendrew shared the 1962 Nobel Prize in Chemistry with Max Perutz, for their work at the Cavendish Laboratory to investigate the structure of heme-containing proteins.

A metalloproteinase, or metalloprotease, is any protease enzyme whose catalytic mechanism involves a metal. An example of this would be ADAM12 which plays a significant role in the fusion of muscle cells during embryo development, in a process known as myogenesis.

Lipoprotein lipase

Lipoprotein lipase (LPL) is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water-soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins (VLDL), into two free fatty acids and one monoacylglycerol molecule. It is also involved in promoting the cellular uptake of chylomicron remnants, cholesterol-rich lipoproteins, and free fatty acids. LPL requires ApoC-II as a cofactor.

Colipase

Colipase, abbreviated CLPS, is a protein co-enzyme required for optimal enzyme activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin. Its function is to prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.

MRC Laboratory of Molecular Biology

The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical research laboratory with a much broader focus.

Tom Blundell British biochemist

Sir Thomas Leon Blundell, is a British biochemist, structural biologist, and science administrator. He was a member of the team of Dorothy Hodgkin that solved in 1969 the first structure of a protein hormone, insulin. Blundell has made contributions to the structural biology of polypeptide hormones, growth factors, receptor activation, signal transduction, and DNA double-strand break repair, subjects important in cancer, tuberculosis, and familial diseases. He has developed software for protein modelling and understanding the effects of mutations on protein function, leading to new approaches to structure-guided and Fragment-based lead discovery. In 1999 he co-founded the oncology company Astex Therapeutics, which has moved ten drugs into clinical trials. Blundell has played central roles in restructuring British research councils and, as President of the UK Science Council, in developing professionalism in the practice of science.

Cyclol Structural model of a folded, globular protein

The cyclol hypothesis is the first structural model of a folded, globular protein. It was developed by Dorothy Wrinch in the late 1930s, and was based on three assumptions. Firstly, the hypothesis assumes that two peptide groups can be crosslinked by a cyclol reaction ; these crosslinks are covalent analogs of non-covalent hydrogen bonds between peptide groups. These reactions have been observed in the ergopeptides and other compounds. Secondly, it assumes that, under some conditions, amino acids will naturally make the maximum possible number of cyclol crosslinks, resulting in cyclol molecules and cyclol fabrics. These cyclol molecules and fabrics have never been observed. Finally, the hypothesis assumes that globular proteins have a tertiary structure corresponding to Platonic solids and semiregular polyhedra formed of cyclol fabrics with no free edges. Such "closed cyclol" molecules have not been observed either.

Eleanor Joy Dodson FRS is an Australian-born biologist who specialises in the computational modelling of protein crystallography. She holds a chair in the Department of Chemistry at the University of York. She is the widow of the scientist Guy Dodson.

Dame Carol Vivien Robinson, is a British chemist and President of the Royal Society of Chemistry. She is a Royal Society Research Professor at the Physical and Theoretical Chemistry Laboratory at the University of Oxford, as well as the Dr Lee's Professor of Physical and Theoretical Chemistry, and a Professorial Fellow at Exeter College. She was previously Professor of Mass Spectrometry at the Department of Chemistry of the University of Cambridge.

HEAT repeat

A HEAT repeat is a protein tandem repeat structural motif composed of two alpha helices linked by a short loop. HEAT repeats can form alpha solenoids, a type of solenoid protein domain found in a number of cytoplasmic proteins. The name "HEAT" is an acronym for four proteins in which this repeat structure is found: Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1. HEAT repeats form extended superhelical structures which are often involved in intracellular transport; they are structurally related to armadillo repeats. The nuclear transport protein importin beta contains 19 HEAT repeats.

Brian Kobilka

Brian Kent Kobilka is an American physiologist and a recipient of the 2012 Nobel Prize in Chemistry with Robert Lefkowitz for discoveries that reveal the workings of G protein-coupled receptors. He is currently a professor in the department of Molecular and Cellular Physiology at Stanford University School of Medicine. He is also a co-founder of ConfometRx, a biotechnology company focusing on G protein-coupled receptors. He was named a member of the National Academy of Sciences in 2011.

Lipase

A lipase is any enzyme that catalyzes the hydrolysis of fats (lipids). Lipases are a subclass of the esterases.

`

Peter Colman

Peter Malcolm Colman is the head of the structural biology division at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia.

Gideon Davies Professor of Chemistry

Gideon John Davies FRS FRSC FMedSci in the York Structural Biology Laboratory (YSBL) at the University of York, UK. Davies is best known for his ground-breaking studies into carbohydrate-active enzymes, notably analysing the conformational and mechanistic basis for catalysis and applying this for societal benefit. In 2016 Davies was made the Royal Society Ken Murray Research Professor at the University of York.

Natalie Strynadka

Natalie C. J. Strynadka FRS is a professor of Biochemistry in the Department of Biochemistry and Molecular Biology at the University of British Columbia.

Kiyoshi Nagai Japanese structural biologist

Kiyoshi Nagai was a Japanese structural biologist at the MRC Laboratory of Molecular Biology Cambridge, UK. He was known for his work on the mechanism of RNA splicing and structures of the spliceosome.

References

  1. 1 2 3 "DODSON, Prof. Eleanor Joy". Who's Who . ukwhoswho.com. 2014 (online Oxford University Press ed.). A & C Black, an imprint of Bloomsbury Publishing plc.(subscription or UK public library membership required)(subscription required)
  2. Professor Guy Dodson, Department of Chemistry, University of York, archived from the original on 2 January 2013, retrieved 29 December 2012.
  3. De Meyts, P. (2013). "In Memoriam: Guy Dodson (1937–2012)". Frontiers in Endocrinology. 4. doi:10.3389/fendo.2013.00033. PMC   3604789 .
  4. 1 2 Wigley, D.B.; Davies, G.J.; Dodson, E.J.; Maxwell, A; Dodson, G (1991). "Crystal structure of an N-terminal fragment of the DNA gyrase B protein". Nature. 351 (6328): 624–629. Bibcode:1991Natur.351..624W. doi:10.1038/351624a0. PMID   1646964.
  5. Davies, G. J.; Dodson, G. G.; Hubbard, R. E.; Tolley, S. P.; Dauter, Z.; Wilson, K. S.; Hjort, C.; Mikkelsen, J. M. L.; Rasmussen, G.; Schülein, M. (1993). "Structure and function of endoglucanase V". Nature. 365 (6444): 362–4. Bibcode:1993Natur.365..362D. doi:10.1038/365362a0. PMID   8377830.
  6. Baker, E. N. (2013). "Guy Dodson FRS (1937–2012)". Acta Crystallographica Section D. 69 (3): 490. doi: 10.1107/S0907444913004186 .
  7. Prof Guy Dodson on YouTube
  8. Written evidence submitted by Professor Guy Dodson, FRS, FMS, ForMemINSA, Parliament of the United Kingdom
  9. 1 2 Guy Dodson's publications indexed by the Scopus bibliographic database. (subscription required)
  10. Blundell, T. L.; Dodson, G. G.; Dodson, E.; Hodgkin, D. C.; Vijayan, M. (1971). "X-ray analysis and the structure of insulin". Recent progress in hormone research. 27: 1–40. PMID   4946130.
  11. Blundell, T.L.; Cutfield, J.F.; Cutfield, S.M.; Dodson, E.J.; Dodson, G.G.; Hodgkin, D.C.; Mercola, D.A.; Vijayan, M. (1971). "Atomic positions in rhombohedral 2-zinc insulin crystals". Nature. 231 (5304): 506–511. Bibcode:1971Natur.231..506B. doi:10.1038/231506a0. PMID   4932997.
  12. Adam, M. G.; Coller, L.; Hodgkin, D. C.; Dodson, G. G. (1966). "X-ray crystallographic studies on zinc insulin crystals". The American Journal of Medicine. 40 (5): 667–671. doi:10.1016/0002-9343(66)90146-X. PMID   5941965.
  13. Dodson, Guy (2002). "Dorothy Mary Crowfoot Hodgkin, O.M. 12 May 1910 – 29 July 1994". Biographical Memoirs of Fellows of the Royal Society . 48: 179–219. doi:10.1098/rsbm.2002.0011.
  14. Brzozowski, A. M.; Derewenda, U.; Derewenda, Z. S.; Dodson, G. G.; Lawson, D. M.; Turkenburg, J. P.; Bjorkling, F.; Huge-Jensen, B.; Patkar, S. A.; Thim, L. (1991). "A model for interfacial activation in lipases from the structure of a fungal lipase-inhibitor complex". Nature. 351 (6326): 491. Bibcode:1991Natur.351..491B. doi:10.1038/351491a0. PMID   2046751.
  15. Brady, L.; Brzozowski, A. M.; Derewenda, Z. S.; Dodson, E.; Dodson, G.; Tolley, S.; Turkenburg, J. P.; Christiansen, L.; Huge-Jensen, B.; Norskov, L.; Thim, L.; Menge, U. (1990). "A serine protease triad forms the catalytic centre of a triacylglycerol lipase". Nature. 343 (6260): 767–70. Bibcode:1990Natur.343..767B. doi:10.1038/343767a0. PMID   2304552.
  16. Perutz, M. F.; Wilkinson, A. J.; Paoli, M.; Dodson, G. G. (1998). "The Stereochemical Mechanism of the Cooperative Effects in Hemoglobin Revisited". Annual Review of Biophysics and Biomolecular Structure. 27: 1. doi:10.1146/annurev.biophys.27.1.1.
  17. Dodson, Eleanor (2020). "Guy Dodson. 13 January 1937—24 December 2012". Biographical Memoirs of Fellows of the Royal Society.
  18. "EC/1994/13:Dodson, George Guy". London: The Royal Society. Archived from the original on 28 October 2014. Retrieved 29 October 2014.