Number of half-lives elapsed | Fraction remaining | Percentage remaining | |
---|---|---|---|

0 | 1⁄1 | 100 | |

1 | 1⁄2 | 50 | |

2 | 1⁄4 | 25 | |

3 | 1⁄8 | 12 | .5 |

4 | 1⁄16 | 6 | .25 |

5 | 1⁄32 | 3 | .125 |

6 | 1⁄64 | 1 | .5625 |

7 | 1⁄128 | 0 | .78125 |

n | 1⁄2^{n} | 100⁄2^{n} |

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**Half-life** (symbol ** t_{½}**) is the time required for a quantity (of substance) to reduce to half of its initial value. The term is commonly used in nuclear physics to describe how quickly unstable atoms undergo radioactive decay or how long stable atoms survive. The term is also used more generally to characterize any type of exponential (or, rarely, non-exponential) decay. For example, the medical sciences refer to the biological half-life of drugs and other chemicals in the human body. The converse of half-life (in exponential growth) is doubling time.

- Probabilistic nature
- Formulas for half-life in exponential decay
- Half-life and reaction orders
- Decay by two or more processes
- Examples
- In non-exponential decay
- In biology and pharmacology
- See also
- References
- External links

The original term, *half-life period*, dating to Ernest Rutherford's discovery of the principle in 1907, was shortened to *half-life* in the early 1950s.^{ [1] } Rutherford applied the principle of a radioactive element's half-life in studies of age determination of rocks by measuring the decay period of radium to lead-206.

Half-life is constant over the lifetime of an exponentially decaying quantity, and it is a characteristic unit for the exponential decay equation. The accompanying table shows the reduction of a quantity as a function of the number of half-lives elapsed.

A half-life often describes the decay of discrete entities, such as radioactive atoms. In that case, it does not work to use the definition that states "half-life is the time required for exactly half of the entities to decay". For example, if there is just one radioactive atom, and its half-life is one second, there will *not* be "half of an atom" left after one second.

Instead, the half-life is defined in terms of probability: "Half-life is the time required for exactly half of the entities to decay * on average *". In other words, the *probability* of a radioactive atom decaying within its half-life is 50%.^{ [2] }

For example, the image on the right is a simulation of many identical atoms undergoing radioactive decay. Note that after one half-life there are not *exactly* one-half of the atoms remaining, only *approximately*, because of the random variation in the process. Nevertheless, when there are many identical atoms decaying (right boxes), the law of large numbers suggests that it is a *very good approximation* to say that half of the atoms remain after one half-life.

Various simple exercises can demonstrate probabilistic decay, for example involving flipping coins or running a statistical computer program.^{ [3] }^{ [4] }^{ [5] }

An exponential decay can be described by any of the following four equivalent formulas:^{ [6] }^{: 109–112 }

where

*N*_{0}is the initial quantity of the substance that will decay (this quantity may be measured in grams, moles, number of atoms, etc.),*N*(*t*) is the quantity that still remains and has not yet decayed after a time t,*t*_{½}is the half-life of the decaying quantity,- τ is a positive number called the mean lifetime of the decaying quantity,
- λ is a positive number called the decay constant of the decaying quantity.

The three parameters *t*_{½}, τ, and λ are directly related in the following way:

where ln(2) is the natural logarithm of 2 (approximately 0.693).^{ [6] }^{: 112 }

In chemical kinetics, the value of the half-life depends on the reaction order:

__Zero order kinetics:__The rate of this kind of reaction does not depend on the substrate concentration, [A]:The integrated rate law of zero order kinetics is:In order to find the half-life, we have to replace the concentration value for the initial concentration divided by 2:and isolate the time:This*t*_{½}formula indicates that the half-life for a zero order reaction depends on the initial concentration and the rate constant.__First order kinetics:__In first order reactions, the concentration of the reactant will decrease exponentiallyas time progresses until it reaches zero, and the half-life will be constant, independent of concentration.The time

*t*_{½}for [A] to decrease from [A]_{0}to 1/2[A]_{0}in a first-order reaction is given by the following equation:It can be solved forFor a first-order reaction, the half-life of a reactant is independent of its initial concentration. Therefore, if the concentration of A at some arbitrary stage of the reaction is [A], then it will have fallen to 1/2[A] after a further interval of Hence, the half-life of a first order reaction is given as the following:The half-life of a first order reaction is independent of its initial concentration and depends solely on the reaction rate constant, k.__Second order kinetics:__In second order reactions, the concentration [A] of the reactant decreases following this formula:We replace [A] for 1/2[A]_{0}in order to calculate the half-life of the reactant Aand isolate the time of the half-life (*t*_{½}):This shows that the half-life of second order reactions depends on the initial concentration and rate constant.

Some quantities decay by two exponential-decay processes simultaneously. In this case, the actual half-life *T*_{½} can be related to the half-lives *t*_{1} and *t*_{2} that the quantity would have if each of the decay processes acted in isolation:

For three or more processes, the analogous formula is:

For a proof of these formulas, see Exponential decay § Decay by two or more processes.

There is a half-life describing any exponential-decay process. For example:

- As noted above, in radioactive decay the half-life is the length of time after which there is a 50% chance that an atom will have undergone nuclear decay. It varies depending on the atom type and isotope, and is usually determined experimentally. See List of nuclides.
- The current flowing through an RC circuit or RL circuit decays with a half-life of ln(2)
*RC*or ln(2)*L*/*R*, respectively. For this example the term half time tends to be used rather than "half-life", but they mean the same thing. - In a chemical reaction, the half-life of a species is the time it takes for the concentration of that substance to fall to half of its initial value. In a first-order reaction the half-life of the reactant is ln(2)/
*λ*, where λ (also denoted as k) is the reaction rate constant.

The term "half-life" is almost exclusively used for decay processes that are exponential (such as radioactive decay or the other examples above), or approximately exponential (such as biological half-life discussed below). In a decay process that is not even close to exponential, the half-life will change dramatically while the decay is happening. In this situation it is generally uncommon to talk about half-life in the first place, but sometimes people will describe the decay in terms of its "first half-life", "second half-life", etc., where the first half-life is defined as the time required for decay from the initial value to 50%, the second half-life is from 50% to 25%, and so on.^{ [7] }

A biological half-life or elimination half-life is the time it takes for a substance (drug, radioactive nuclide, or other) to lose one-half of its pharmacologic, physiologic, or radiological activity. In a medical context, the half-life may also describe the time that it takes for the concentration of a substance in blood plasma to reach one-half of its steady-state value (the "plasma half-life").

The relationship between the biological and plasma half-lives of a substance can be complex, due to factors including accumulation in tissues, active metabolites, and receptor interactions.^{ [8] }

While a radioactive isotope decays almost perfectly according to so-called "first order kinetics" where the rate constant is a fixed number, the elimination of a substance from a living organism usually follows more complex chemical kinetics.

For example, the biological half-life of water in a human being is about 9 to 10 days,^{ [9] } though this can be altered by behavior and other conditions. The biological half-life of caesium in human beings is between one and four months.

The concept of a half-life has also been utilized for pesticides in plants,^{ [10] } and certain authors maintain that pesticide risk and impact assessment models rely on and are sensitive to information describing dissipation from plants.^{ [11] }

In epidemiology, the concept of half-life can refer to the length of time for the number of incident cases in a disease outbreak to drop by half, particularly if the dynamics of the outbreak can be modeled exponentially.^{ [12] }^{ [13] }

In a chemical reaction, **chemical equilibrium** is the state in which both the reactants and products are present in concentrations which have no further tendency to change with time, so that there is no observable change in the properties of the system. This state results when the forward reaction proceeds at the same rate as the reverse reaction. The reaction rates of the forward and backward reactions are generally not zero, but they are equal. Thus, there are no net changes in the concentrations of the reactants and products. Such a state is known as dynamic equilibrium.

In physical chemistry, the **Arrhenius equation** is a formula for the temperature dependence of reaction rates. The equation was proposed by Svante Arrhenius in 1889, based on the work of Dutch chemist Jacobus Henricus van 't Hoff who had noted in 1884 that the van 't Hoff equation for the temperature dependence of equilibrium constants suggests such a formula for the rates of both forward and reverse reactions. This equation has a vast and important application in determining the rate of chemical reactions and for calculation of energy of activation. Arrhenius provided a physical justification and interpretation for the formula. Currently, it is best seen as an empirical relationship. It can be used to model the temperature variation of diffusion coefficients, population of crystal vacancies, creep rates, and many other thermally-induced processes/reactions. The Eyring equation, developed in 1935, also expresses the relationship between rate and energy.

**Exponential growth** is a process that increases quantity over time. It occurs when the instantaneous rate of change of a quantity with respect to time is proportional to the quantity itself. Described as a function, a quantity undergoing exponential growth is an exponential function of time, that is, the variable representing time is the exponent.

**Radioactive decay** is the process by which an unstable atomic nucleus loses energy by radiation. A material containing unstable nuclei is considered *radioactive*. Three of the most common types of decay are *alpha decay*, *beta decay*, and *gamma decay*, all of which involve emitting one or more particles. The weak force is the mechanism that is responsible for beta decay, while the other two are governed by the electromagnetism and nuclear force. A fourth type of common decay is electron capture, in which an unstable nucleus captures an inner electron from one of the electron shells. The loss of that electron from the shell results in a cascade of electrons dropping down to that lower shell resulting in emission of discrete X-rays from the transitions. A common example is iodine-125 commonly used in medical settings.

The **reaction rate** or **rate of reaction** is the speed at which a chemical reaction takes place, defined as proportional to the increase in the concentration of a product per unit time and to the decrease in the concentration of a reactant per unit time. Reaction rates can vary dramatically. For example, the oxidative rusting of iron under Earth's atmosphere is a slow reaction that can take many years, but the combustion of cellulose in a fire is a reaction that takes place in fractions of a second. For most reactions, the rate decreases as the reaction proceeds. A reaction's rate can be determined by measuring the changes in concentration over time.

A quantity is subject to **exponential decay** if it decreases at a rate proportional to its current value. Symbolically, this process can be expressed by the following differential equation, where N is the quantity and λ (lambda) is a positive rate called the **exponential decay constant**, **disintegration constant**, **rate constant**, or **transformation constant**:

**Chemical kinetics**, also known as **reaction kinetics**, is the branch of physical chemistry that is concerned with understanding the rates of chemical reactions. It is to be contrasted with chemical thermodynamics, which deals with the direction in which a reaction occurs but in itself tells nothing about its rate. Chemical kinetics includes investigations of how experimental conditions influence the speed of a chemical reaction and yield information about the reaction's mechanism and transition states, as well as the construction of mathematical models that also can describe the characteristics of a chemical reaction.

**Specific activity** is the activity per unit mass of a radionuclide and is a physical property of that radionuclide.

The **equilibrium constant** of a chemical reaction is the value of its reaction quotient at chemical equilibrium, a state approached by a dynamic chemical system after sufficient time has elapsed at which its composition has no measurable tendency towards further change. For a given set of reaction conditions, the equilibrium constant is independent of the initial analytical concentrations of the reactant and product species in the mixture. Thus, given the initial composition of a system, known equilibrium constant values can be used to determine the composition of the system at equilibrium. However, reaction parameters like temperature, solvent, and ionic strength may all influence the value of the equilibrium constant.

In chemical kinetics a **reaction rate constant** or **reaction rate coefficient**, *k*, quantifies the rate and direction of a chemical reaction.

In chemistry, the **rate law** or **rate equation** for a reaction is an equation that links the initial or forward reaction rate with the concentrations or pressures of the reactants and constant parameters. For many reactions, the initial rate is given by a power law such as

In pharmacokinetics, the **effective half-life** is the rate of accumulation or elimination of a biochemical or pharmacological substance in an organism; it is the analogue of biological half-life when the kinetics are governed by multiple independent mechanisms. This is seen when there are multiple mechanisms of elimination, or when a drug occupies multiple pharmacological compartments. It reflects the cumulative effect of the individual half-lives, as observed by the changes in the actual serum concentration of a drug under a given dosing regimen. The complexity of biological systems means that most pharmacological substances do not have a single mechanism of elimination, and hence the observed or effective half-life does not reflect that of a single process, but rather the summation of multiple independent processes.

In the physical sciences, **relaxation** usually means the return of a perturbed system into equilibrium. Each relaxation process can be categorized by a **relaxation time** τ. The simplest theoretical description of relaxation as function of time *t* is an exponential law exp(−*t*/*τ*).

In chemistry, **molecularity** is the number of molecules that come together to react in an elementary (single-step) reaction and is equal to the sum of stoichiometric coefficients of reactants in the elementary reaction with effective collision and correct orientation. Depending on how many molecules come together, a reaction can be unimolecular, bimolecular or even trimolecular.

The principle of **detailed balance** can be used in kinetic systems which are decomposed into elementary processes. It states that at equilibrium, each elementary process is in equilibrium with its reverse process.

In science, ** e-folding** is the time interval in which an exponentially growing quantity increases by a factor of

In nuclear physics, **secular equilibrium** is a situation in which the quantity of a radioactive isotope remains constant because its production rate is equal to its decay rate.

In chemistry, **transition state theory** (**TST**) explains the reaction rates of elementary chemical reactions. The theory assumes a special type of chemical equilibrium (quasi-equilibrium) between reactants and activated transition state complexes.

**Equilibrium chemistry** is concerned with systems in chemical equilibrium. The unifying principle is that the free energy of a system at equilibrium is the minimum possible, so that the slope of the free energy with respect to the reaction coordinate is zero. This principle, applied to mixtures at equilibrium provides a definition of an equilibrium constant. Applications include acid–base, host–guest, metal–complex, solubility, partition, chromatography and redox equilibria.

**Potassium–calcium dating**, abbreviated **K–Ca dating**, is a radiometric dating method used in geochronology. It is based upon measuring the ratio of a parent isotope of potassium to a daughter isotope of calcium. This form of radioactive decay is accomplished through beta decay.

- ↑ John Ayto,
*20th Century Words*(1989), Cambridge University Press. - ↑ Muller, Richard A. (April 12, 2010).
*Physics and Technology for Future Presidents*. Princeton University Press. pp. 128–129. ISBN 9780691135045. - ↑ Chivers, Sidney (March 16, 2003). "Re: What happens during half-lifes [sic] when there is only one atom left?". MADSCI.org.
- ↑ "Radioactive-Decay Model". Exploratorium.edu. Retrieved 2012-04-25.
- ↑ Wallin, John (September 1996). "Assignment #2: Data, Simulations, and Analytic Science in Decay". Astro.GLU.edu. Archived from the original on 2011-09-29.
`{{cite web}}`

: CS1 maint: unfit URL (link) - 1 2 Rösch, Frank (September 12, 2014).
*Nuclear- and Radiochemistry: Introduction*. Vol. 1. Walter de Gruyter. ISBN 978-3-11-022191-6. - ↑ Jonathan Crowe; Tony Bradshaw (2014).
*Chemistry for the Biosciences: The Essential Concepts*. p. 568. ISBN 9780199662883. - ↑ Lin VW; Cardenas DD (2003).
*Spinal cord medicine*. Demos Medical Publishing, LLC. p. 251. ISBN 978-1-888799-61-3. - ↑ Pang, Xiao-Feng (2014).
*Water: Molecular Structure and Properties*. New Jersey: World Scientific. p. 451. ISBN 9789814440424. - ↑ Australian Pesticides and Veterinary Medicines Authority (31 March 2015). "Tebufenozide in the product Mimic 700 WP Insecticide, Mimic 240 SC Insecticide". Australian Government. Retrieved 30 April 2018.
- ↑ Fantke, Peter; Gillespie, Brenda W.; Juraske, Ronnie; Jolliet, Olivier (11 July 2014). "Estimating Half-Lives for Pesticide Dissipation from Plants".
*Environmental Science & Technology*.**48**(15): 8588–8602. Bibcode:2014EnST...48.8588F. doi: 10.1021/es500434p . PMID 24968074. - ↑ Balkew, Teshome Mogessie (December 2010).
*The SIR Model When S(t) is a Multi-Exponential Function*(Thesis). East Tennessee State University. - ↑ Ireland, MW, ed. (1928).
*The Medical Department of the United States Army in the World War, vol. IX: Communicable and Other Diseases*. Washington: U.S.: U.S. Government Printing Office. pp. 116–7.

Look up ** half-life ** in Wiktionary, the free dictionary.

Wikimedia Commons has media related to Half times .

- https://www.calculator.net/half-life-calculator.html Comprehensive half-life calculator
- Welcome to Nucleonica, Nucleonica.net (archived 2017)
- wiki: Decay Engine, Nucleonica.net (archived 2016)
- System Dynamics – Time Constants, Bucknell.edu
- Researchers Nikhef and UvA measure slowest radioactive decay ever: Xe-124 with 18 billion trillion years
- https://academo.org/demos/radioactive-decay-simulator/ Interactive radioactive decay simulator demonstrating how half-life is related to the rate of decay

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