Hargovind Laxmishanker Trivedi

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Hargovind Laxmishanker Trivedi
Dr. Hargovind Laxmishanker Trivedi.jpg
Trivedi in 2015
Born(1932-08-31)31 August 1932
Died2 October 2019(2019-10-02) (aged 87)
Occupation Nephrologist, immunologist, transplant surgeon, stem cell researcher
Spouse(s)Sunita Trivedi
Parent(s)Laxmishanker Trivedi
Awards Padma Shri (2015)

Hargovind Laxmishanker "H. L." Trivedi (31 August 1932 – 2 October 2019) was an Indian nephrologist, immunologist, transplant surgeon and stem cell researcher.

Immunology branch of physiology studying the immune system

Immunology is a branch of biology that covers the study of immune systems in all organisms. Immunology charts, measures, and contextualizes the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; and the physical, chemical, and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has applications in numerous disciplines of medicine, particularly in the fields of organ transplantation, oncology, rheumatology, virology, bacteriology, parasitology, psychiatry, and dermatology.

Organ transplantation moving of an organ from one body or body region to another

Organ transplantation is a medical procedure in which an organ is removed from one body and placed in the body of a recipient, to replace a damaged or missing organ. The donor and recipient may be at the same location, or organs may be transported from a donor site to another location. Organs and/or tissues that are transplanted within the same person's body are called autografts. Transplants that are recently performed between two subjects of the same species are called allografts. Allografts can either be from a living or cadaveric source.

Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.

Contents

He was a pioneer of transplantation medicine in India and a founding director of the Kidney Hospital in Ahmedabad. He and his team performed more than 5200 kidney transplantations. He was awarded the Padma Shri in 2015.

Ahmedabad Metropolis in Gujarat, India

Ahmedabad is the largest city and former capital of the Indian state of Gujarat. It is the administrative headquarters of the Ahmadabad district and the seat of the Gujarat High Court. Ahmedabad's population of 5,633,927 makes it the fifth-most populous city in India, and the encompassing urban agglomeration population estimated at 6,357,693 is the seventh-most populous in India. Ahmadabad is located on the banks of the Sabarmati River, 30 km (19 mi) from the state capital Gandhinagar, which is its twin city.

Kidney transplantation surgical operation

Kidney transplantation or renal transplantation is the organ transplant of a kidney into a patient with end-stage renal disease. Kidney transplantation is typically classified as deceased-donor or living-donor transplantation depending on the source of the donor organ.

Padma Shri Fourth highest civilian award in the Republic of India

Padma Shri is the fourth highest civilian award in the Republic of India, after the Bharat Ratna, the Padma Vibhushan and the Padma Bhushan. It is awarded by the Government of India, every year on India's Republic Day.

Early life

Trivedi was born on 31 August 1932 in the village of Charadva near Halvad (now in Morbi district, Gujarat). [1] [2] His father Laxmishankar Trivedi was a teacher. [3] He completed his primary education from Lunsar village near Wankaner in. [1] He studied pre-medical at the Faculty of Science, Dharamsinhji College, Rajkot from 1951 to 1953 and then an MBBS degree at the B. J. Medical College, Ahmedabad from 1953 to 1963. [1] [2]

Halvad city in Gujarat, India

Halvad is a town and a municipality in Morbi district in the Gujarat state of India.

Morbi district district in Gujarat, India

Morbi District is in the state of Gujarat, India. It was formed on August 15, 2013, along with several other districts, on the 67th Independence Day of India. Morbi city is the administrative headquarters of the district. The district has 5 talukas - Morbi, Maliya, Tankara, Wankaner and Halvad. Morbi city is the administrative headquarters of Morbi district. The town of Morbi is situated on the Machchhu River, 35 km from the sea and 60 km from Rajkot. As per 2011 census data, the city had a population of 2,10,451 and average literacy rate of 83.64%.

Wankaner city in Gujarat, India

Wankaner is a city and a municipality in Morbi district in the State of Gujarat. Until 2013, Wankaner was part of the Rajkot district.

Career

He had higher training for two years in the Cleveland Clinic in the US, and practiced for eight years in Hamilton, Ontario, Canada. A visit to his native land changed his mind and he returned to Ahmedabad in 1977 to continue his practice in India. [1] [3] [4] He joined B. J. Medical College as a professor of nephrology. [1] [5]

Cleveland Clinic Hospital in Ohio, United States

The Cleveland Clinic is an American academic medical center based in Cleveland, Ohio. Owned and operated by the Cleveland Clinic Foundation, an Ohio nonprofit corporation established in 1921, it runs a 170 acre campus in Cleveland, as well as 11 regional hospitals and 19 family health centers in northeast Ohio, and hospitals in Florida and Nevada. Tomislav Mihaljevic is the president and CEO.

Hamilton, Ontario City in Ontario, Canada

Hamilton is a port city in the Canadian province of Ontario. An industrialized city in the Golden Horseshoe at the west end of Lake Ontario, Hamilton has a population of 536,917, and its census metropolitan area, which includes Burlington and Grimsby, has a population of 747,545. The city is about 40 miles (64 km) southwest of Toronto, with which the Greater Toronto and Hamilton Area (GTHA) is formed.

Ontario Province of Canada

Ontario is one of the 13 provinces and territories of Canada. Located in Central Canada, it is Canada's most populous province accounting for 38.3 percent of the country's population, and is the second-largest province in total area. Ontario is fourth-largest jurisdiction in total area when the territories of the Northwest Territories and Nunavut are included. It is home to the nation's capital city, Ottawa, and the nation's most populous city, Toronto, which is also Ontario's provincial capital.

He founded the Institute of Kidney Diseases and Research Centre (IKDRC, also known as Kidney Hospital) located in the Ahmedabad Civil Hospital campus on 7 October 1981. His friends and industrialists Rasiklal Doshi and Mafatlal Mehta helped with donation of 1 crore (equivalent to 15 croreorUS$2.2 million in 2018). The institute was moved to the new building in 1992. The Institute of Transplantation Sciences (ITS) was established in 1997 in the same campus. [1] [2] [5] [6] [7] It is the largest kidney hospital in the world with 438 beds. He and his team completed more than 5200 kidney transplantations in the institute. It is also the only public-sector liver transplantation institute in India. [1] [7] IKDRC-ITS was upgraded into the Gujarat University of Transplantation Sciences in 2015 and Trivedi was appointed its Pro-Chancellor. [7] [8]

Ahmedabad Civil Hospital is a public hospital located in Ahmedabad, Gujarat India, with facilities for specialised diagnostic, therapeutic and rehabilitative patient care. Civil hospital. Spread over 110 acres (45 ha) of land, it houses a number of prestigious institutes and allied hospitals, the Gujarat Medical Council and Gujarat Nursing Council. It is affiliated to B.J. Medical College in Ahmedabad. The new building and infrastructure of CHA came into existence in 1858 with the help of donations given by Shri Hutheesing, Shri Premabhai and Surgeon General D Wyllie. The hospital is one of the oldest and most modern in India, treating about 6 to 6.5 lakhs outdoor patients and admitting 70,000 patients annually. It performs about 26,000 surgeries and 6500 deliveries per year. It has been ranked as 5th in list of Top 10 largest hospital published by health care globle.

Liver transplantation medical procedure

Liver transplantation or hepatic transplantation is the replacement of a diseased liver with the healthy liver from another person (allograft). Liver transplantation is a treatment option for end-stage liver disease and acute liver failure, although availability of donor organs is a major limitation. The most common technique is orthotopic transplantation, in which the native liver is removed and replaced by the donor organ in the same anatomic position as the original liver. The surgical procedure is complex, requiring careful harvest of the donor organ and meticulous implantation into the recipient. Liver transplantation is highly regulated, and only performed at designated transplant medical centers by highly trained transplant physicians and supporting medical team. The duration of the surgery ranges from 4 to 18 hours depending on outcome. Favorable outcomes require careful screening for eligible recipient, as well as a well-calibrated live or cadaveric donor match.

Gujarat University of Transplantation Sciences

Gujarat University of Transplantation Sciences (GUTS) is a state university located at Ahmedabad, Gujarat, India. It was established in 2015 by the Government of Gujarat and focuses on transplantation sciences.

He founded the Indian Society of Organ Transplantation. He was also the founding chief editor of the Indian Journal of Transplantation and Indian Journal of Nephrology. He held several patents on stem-cell therapy for transplantation tolerance and insulin producing stem cells. [7] His autobiography Tryst with Destiny (1996) is translated in Gujarati as Purusharth Potano: Prasad Prabhuno (2016) by Aruna Vanikar. [5]

Insulin mammalian protein found in Homo sapiens

Insulin is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body. It regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of carbohydrates, especially glucose from the blood into liver, fat and skeletal muscle cells. In these tissues the absorbed glucose is converted into either glycogen via glycogenesis or fats (triglycerides) via lipogenesis, or, in the case of the liver, into both. Glucose production and secretion by the liver is strongly inhibited by high concentrations of insulin in the blood. Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. It is therefore an anabolic hormone, promoting the conversion of small molecules in the blood into large molecules inside the cells. Low insulin levels in the blood have the opposite effect by promoting widespread catabolism, especially of reserve body fat.

He died on 2 October 2019 in Ahmedabad after prolonged illness. He suffered from neurological and liver ailments, as well as Parkinson's disease. [1] [2] [9] [10]

Recognition

Trivedi (left) being presented Padma Shri by the President of India, Pranab Mukherjee, at a Civil Investiture Ceremony, at Rashtrapati Bhavan, in New Delhi on 8 April 2015 The President, Shri Pranab Mukherjee presenting the Padma Shri Award to Dr. Hargovind Laxmishanker Trivedi, at a Civil Investiture Ceremony, at Rashtrapati Bhavan, in New Delhi on April 08, 2015.jpg
Trivedi (left) being presented Padma Shri by the President of India, Pranab Mukherjee, at a Civil Investiture Ceremony, at Rashtrapati Bhavan, in New Delhi on 8 April 2015

Trivedi was a Fellow of the Royal College of Physicians of Canada (FRCP(C)). [11] In 2006, the Institute of Transplantation Sciences was renamed Dr. H. L. Trivedi Institute of Transplantation Sciences in his honour. [8] He was awarded with an honorary Doctor of Science (D. Sc.) degree by King George's Medical University in 2009. [7] He was felicitated as a Nagar Ratna by Ahmedabad Municipal Corporation in 2014. [12]

He was honoured by the Government of India in 2015 with the Padma Shri, the fourth highest Indian civilian award. [13] [14] He was also awarded by The Transplantion Society in 2018. [7]

Selected papers

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References

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