Henry Hallett Dale

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Henry Dale

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Henry Hallett Dale

(1875-06-09)9 June 1875
Died23 July 1968(1968-07-23) (aged 93)
Nationality United Kingdom
Education Tollington School
The Leys School
Alma mater
Known for
Scientific career
Website www.rigb.org/our-history/people/d/henry-hallett-dale

Sir Henry Hallett Dale OM GBE PRS [2] (9 June 1875 – 23 July 1968) was an English pharmacologist and physiologist. [3] For his study of acetylcholine as agent in the chemical transmission of nerve pulses (neurotransmission) he shared the 1936 Nobel Prize in Physiology or Medicine with Otto Loewi. [4] [5] [6] [7] [8]


Early life and education

Henry Hallett Dale was born in Islington, London, to Charles James Dale, a pottery manufacturer from Staffordshire, and his wife, Frances Anne Hallett, daughter of a furniture manufacturer, from South Devon. [2] [9] Henry was the third of seven children, one of whom (his younger brother, Benjamin Dale) became an accomplished composer and warden of the Royal Academy of Music. Henry was educated at the local Tollington Park College and then The Leys School Cambridge (one of the school's houses is named after him) and in 1894 entered Trinity College, Cambridge, [10] working under the physiologist John Langley. For a few months in 1903 he also studied under Paul Ehrlich in Frankfurt, Germany. Also in 1903, Dale assisted Ernest Starling and William Bayliss in the vivisection of a dog, by removing the dog's pancreas and then killing the dog with a knife, which ultimately led to the events of the Brown Dog affair. Dale received his Doctor of Medicine degree from Cambridge in 1909. [11] [3]

Career and research

While working at the University College London, he met and became friends with Otto Loewi. Dale became the director of the Department of Biochemistry and Pharmacology at the National Institute for Medical Research in London in 1914. He became a Fullerian Professor of Chemistry at the Royal Institution in 1942. [12] During World War II he served on the scientific advisory panel to the Cabinet.

Although Dale and his colleagues first identified acetylcholine in 1914 as a possible neurotransmitter, Loewi showed its importance in the nervous system. The two men shared the 1936 Nobel Prize for Medicine.

During the 1940s Dale was embroiled in the scientific debate over the nature of signaling at the synapse. Dale and others believed that signaling at the synapse was chemical, while John Carew Eccles and others believed that the synapse was electrical. It was later found that most synaptic signalling is chemical, but there are some synapses that are electrical.

Dale also originated the scheme used to differentiate neurons according to the neurotransmitters they release. Thus, neurons releasing noradrenaline (known in the United States as norepinephrine) are called noradrenergic, neurons releasing GABA are GABAergic, and so on. This is called Dale's principle (sometimes erroneously referred to as Dale's Law), one interpretation of which holds that each neuron releases only one type of neurotransmitter. This particular interpretation of Dale's principle has been shown to be false, as many neurons release neuropeptides and amino acids in addition to classical neurotransmitters such as acetylcholine or biogenic amines (see cotransmission) [ citation needed ](Bear, et al. 2001). This finding, that numerous neurotransmitters can be released by the same neuron, is referred to as the "coexistence principle." This phenomenon was most popularized by the Swedish neuroanatomist and neuropharmacologist Tomas Hökfelt, who is considered to be the "Father of the Coexistence Principle."

Between 1938 and 1960 Dale served as chairman of the Wellcome Trust. [13]

Awards and honours

Dale was elected a Fellow of the Royal Society (FRS) in 1914. [2] In 1926, he was awarded the Cameron Prize for Therapeutics of the University of Edinburgh. He was knighted in 1932, receiving the Knight Grand Cross of the Order of the British Empire in 1943 and the Order of Merit in 1944. He served as president of the Royal Society from 1940 to 1945 and president of the Royal Society of Medicine from 1948 to 1950. The Sir Henry Dale Fellowships of the Wellcome Trust are named in his honour [14] and the Society for Endocrinology awards the Dale Medal [15] annually in his honour.

Personal life

In 1904, Dale had married his first cousin Elen Harriet Hallett and had a son and two daughters. One of their daughters, Alison Sarah Dale, married Alexander R. Todd, who too won the Nobel Prize and served as President of the Royal Society from 1940 to 1945. The Dales lived at Mount Vernon House from 1919 to 1942. [16] Dales's residency at the house is marked by a Greater London Council blue plaque erected in 1981 on the garden wall of the house. [17]

Related Research Articles

John Eccles (neurophysiologist) Australian neurophysiologist (1903–1997)

Sir John Carew Eccles was an Australian neurophysiologist and philosopher who won the 1963 Nobel Prize in Physiology or Medicine for his work on the synapse. He shared the prize with Andrew Huxley and Alan Lloyd Hodgkin.

Neurotransmitter Chemical substance that enables neurotransmission

A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, any main body part or target cell, may be another neuron, but could also be a gland or muscle cell.

Chemical synapse Biological junctions through which neurons signals can be sent

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Acetylcholine Organic chemical and neurotransmitter

Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals as a neurotransmitter. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Parts in the body that use or are affected by acetylcholine are referred to as cholinergic. Substances that increase or decrease the overall activity of the cholinergic system are called cholinergics and anticholinergics, respectively.

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An electrical synapse is a mechanical and electrically conductive link between two neighboring neurons that is formed at a narrow gap between the pre- and postsynaptic neurons known as a gap junction. At gap junctions, such cells approach within about 3.8 nm of each other, a much shorter distance than the 20- to 40-nanometer distance that separates cells at chemical synapse. In many animals, electrical synapse-based systems co-exist with chemical synapses.

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  8. Sabbatini, R.M.E.: Neurons and synapses. The history of its discovery. IV. Chemical transmission. Brain & Mind, 2004.
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  10. "Dale, Henry Hallett (DL894HH)". A Cambridge Alumni Database. University of Cambridge.
  11. Henry Hallett Dale on Nobelprize.org OOjs UI icon edit-ltr-progressive.svg , accessed 1 May 2020
  12. "Fullerian Professorships".
  13. Anon (2015). "Biography of Henry Hallett Dale (1875–1968)". rigb.org. London: Royal Institution. Archived from the original on 8 March 2016.
  14. Anon (2016). "Sir Henry Dale Fellowships". wellcome.ac.uk. London: Wellcome Trust. Archived from the original on 22 June 2016.
  15. "Medals | Society for Endocrinology".
  16. Christopher Hibbert; Ben Weinreb; John Keay; Julia Keay (2010). The London Encyclopaedia. Macmillan Publishers. pp. 563–. ISBN   978-1-4050-4925-2.
  17. "DALE, Sir Henry (1875–1968)". English Heritage . Retrieved 4 July 2020.
Professional and academic associations
Preceded by47th President of the Royal Society
Succeeded by