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Interstate 75 (I-75) is a major north–south Interstate Highway in the Great Lakes and Southeastern regions of the United States. As with most Interstates that end in a five, it is a major cross-country, north–south route, one of the longest in the U.S., from southern Florida to the northern tip of Michigan. It travels from State Road 826 and SR 924 on the Hialeah–Miami Lakes border to Sault Ste. Marie, Michigan, at the Canadian border.
Interstate 24 (I-24) is an Interstate Highway in the Midwestern and Southeastern United States. It runs diagonally from I-57, 10 miles (16 km) south of Marion, Illinois, to Chattanooga, Tennessee, at I-75. As an even-numbered Interstate, it is signed as an east–west route, though the route follows a more southeast–northwest routing, passing through Nashville, Tennessee. Because the routing of I-24 is diagonal, the numbering is a bit unusual as it does not completely follow the Interstate Highway System numbering conventions.
U.S. Route 27 (US 27) is a north–south United States highway in the southern and midwestern United States. The southern terminus is at US 1 in Miami, Florida. The northern terminus is at Interstate 69 (I-69) in Fort Wayne, Indiana. From Miami it goes up the center of Florida, then west to Tallahassee, Florida, and north through such cities and towns as Columbus, Georgia; Rome, Georgia; Chattanooga, Tennessee; Lexington, Kentucky; Cincinnati, Ohio; Oxford, Ohio; Richmond, Indiana; and Fort Wayne, Indiana. It once extended north through Lansing, Michigan, to Cheboygan, Mackinaw City, and for about 3 years as far as St. Ignace.
U.S. Route 79 is a United States highway. The route is officially considered and labeled as a north-south highway, but it is actually more of a diagonal northeast-southwest highway. The highway's northern/eastern terminus is in Russellville, Kentucky, at an intersection with U.S. Highway 68 and KY 80. Its southern/western terminus is in Round Rock, Texas, at an intersection with Interstate 35, ten miles (16 km) north of Austin.
U.S. Route 25 is a north–south United States highway that runs for 750 miles (1,210 km) from Brunswick, Georgia, to the Ohio state line in Covington, Kentucky.
The Appalachian Development Highway System (ADHS) is part of the Appalachian Regional Commission in the United States. It consists of a series of highway corridors in the Appalachia region of the eastern United States. The routes are designed as local and regional routes for improving economic development in the historically isolated region. It was established as part of the Appalachian Regional Development Act of 1965, and has been repeatedly supplemented by various federal and state legislative and regulatory actions. The system consists of a mixture of state, U.S., and Interstate routes. The routes are formally designated as "corridors" and assigned a letter. Signage of these corridors varies from place to place, but where signed are often done so with a distinctive blue-colored sign.
U.S. Route 31E (US 31E) is the easternmost of two parallel routes for U.S. Highway 31 from Nashville, Tennessee, to Louisville, Kentucky.
