Irwin Rose

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Irwin Rose
Irwin Rose, c. 2000
Irwin Allan Rose

(1926-07-16)July 16, 1926
DiedJune 2, 2015(2015-06-02) (aged 88)
NationalityUnited States
Alma mater University of Chicago (BS, PhD) NYU (postdoc)
Known for Ubiquitin-mediated protein degradation
Spouse(s)Zelda Budenstein[ citation needed ]
Children4[ citation needed ]
Awards Nobel Prize in Chemistry (2004)
Scientific career
Fields Biology

Irwin Allan Rose (July 16, 1926 – June 2, 2015) was an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. [1] [2] [3] [4] [5] [6] [7]

Biology is the natural science that studies life and living organisms, including their physical structure, chemical processes, molecular interactions, physiological mechanisms, development and evolution. Despite the complexity of the science, there are certain unifying concepts that consolidate it into a single, coherent field. Biology recognizes the cell as the basic unit of life, genes as the basic unit of heredity, and evolution as the engine that propels the creation and extinction of species. Living organisms are open systems that survive by transforming energy and decreasing their local entropy to maintain a stable and vital condition defined as homeostasis.

Aaron Ciechanover Israeli physician

Aaron Ciechanover is an Israeli biologist, who won the Nobel prize in Chemistry for characterizing the method that cells use to degrade and recycle proteins using ubiquitin.

Avram Hershko Israeli scientist

Avram Hershko is a Hungarian-born Israeli biochemist and Nobel laureate in Chemistry.


Education and early life

Rose was born in Brooklyn, New York, into a secular Jewish family, the son of Ella (Greenwald) and Harry Royze, who owned a flooring store. [8] Rose attended Washington State University for one year prior to serving in the Navy during World War II. Upon returning from the war he received his Bachelor of Science degree in 1948 and his PhD in biochemistry in 1952, both from the University of Chicago. [9] He did his post-doctoral studies at NYU. [10]

Washington State University public university in Pullman, Washington, USA

Washington State University is a public research university in Pullman, Washington. Founded in 1890, WSU is one of the oldest land-grant universities in the American West and features programs in a broad range of academic disciplines. With an undergraduate enrollment of 24,470 and a total enrollment of 29,686, it is the second largest institution of higher education in Washington state behind the University of Washington. The WSU Pullman campus is perched upon a hill, characterized by open spaces, views, deep green conifers, and a restrained red brick and basalt material palette--materials originally found on site. The university is nestled within the spectacular rolling topography of the Palouse in rural eastern Washington and remains intimately connected to the town, the region, and the landscape in which it sits.

A Bachelor of Science is an undergraduate academic degree awarded for completed courses that generally last three to five years, or a person holding such a degree.

University of Chicago Private research university in Chicago, Illinois, United States

The University of Chicago is a private research university in Chicago, Illinois. Founded in 1890, the school is located on a 217-acre campus in Chicago's Hyde Park neighborhood, near Lake Michigan. The University of Chicago holds top-ten positions in various national and international rankings.

Career and research

Rose served on the faculty of Yale School of Medicine's department of biochemistry from 1954 to 1963. He then joined the Fox Chase Cancer Center in 1963 and stayed there until he retired in 1995. [11] He joined University of Pennsylvania during the 1970s and served as a Professor of Physical Biochemistry. [12] He was a distinguished professor-in-residence in the Department of Physiology and Biophysics at the University of California, Irvine School of Medicine at the time his Nobel Prize was announced in 2004. [11]

Yale School of Medicine

The Yale School of Medicine is the graduate medical school at Yale University in New Haven, Connecticut. It was founded in 1810 as The Medical Institution of Yale College, and formally opened in 1813.

Fox Chase Cancer Center is a National Cancer Institute-designated Comprehensive Cancer Center research facility and hospital located in the Fox Chase section of Philadelphia, Pennsylvania, United States. The main facilities of the center are located on property adjoining Burholme Park. The center is part of the Temple University Health System (TUHS) and specializes in the treatment and prevention of cancer.

University of Pennsylvania Private Ivy League research university in Philadelphia, Pennsylvania

The University of Pennsylvania is a private Ivy League research university in Philadelphia, Pennsylvania. It is one of the nine colonial colleges founded prior to the Declaration of Independence and the first institution of higher learning in the United States to refer to itself as a university. Benjamin Franklin, Penn's founder and first president, advocated an educational program that trained leaders in commerce, government, and public service, similar to a modern liberal arts curriculum.

Irwin (Ernie) trained several postdoctoral research fellows while at the Fox Chase Cancer Center in Philadelphia. These included Art Haas, [13] the first to see Ubiquitin chains, Keith Wilkinson, [1] the one to first identify APF-1 as Ubiquitin, and Cecile Pickart, [14] a world class enzymologist in many parts of the Ub system.

Awards and honors

Rose was awarded the Nobel prize in 2004. [15] [16] [17]

Personal life

Rose was married to Zelda Budenstein and had four children. [9] He died on June 2, 2015 at Deerfield, Massachusetts. [9] [18] His wife died in 2016.

Deerfield, Massachusetts Town in Massachusetts, United States

Deerfield is a town in Franklin County, Massachusetts, United States. Settled near the Connecticut River in the 17th century during the colonial era, the population was 5,125 as of the 2010 census. Deerfield is part of the Springfield, Massachusetts Metropolitan Statistical Area in western Massachusetts, lying 30 miles (48 km) north of the city of Springfield.

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  1. 1 2 Wilkinson, Keith; Hershko, Avram (2015). "Irwin Allan Rose (1926–2015) Established role of ubiquitin in the destruction of cellular proteins". Nature . 523 (7562): 532–532. doi:10.1038/523532a. ISSN   0028-0836.
  2. Rose, Irwin (2005), "Early work on the ubiquitin proteasome system, an interview with Irwin Rose. Interview by CDD", Cell Death Differ., 12 (9), pp. 1162–6, doi:10.1038/sj.cdd.4401700, PMID   16094392
  3. "Nobel Prize in Chemistry, 2004. Aaron Ciechanover, Avram Hershko and Irwin Rose", Indian J. Physiol. Pharmacol., 49 (1), p. 121, 2005, PMID   15881872
  4. Latonen, Leena; Laiho, Marikki (2004), "Nobel prize in chemistry goes to three persons with a key role in revealing the ubiquitin-mediated protein degradation pathway", Duodecim; lääketieteellinen aikakauskirja, 120 (24), pp. 2868–71, PMID   15700582
  5. Goldberg, Alfred L (2005), "Nobel committee tags ubiquitin for distinction", Neuron (published Feb 3, 2005), 45 (3), pp. 339–44, doi:10.1016/j.neuron.2005.01.019, PMID   15694320
  6. Neefjes, J; Groothuis, T A M; Dantuma, N P (2004), "The 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation", Nederlands tijdschrift voor geneeskunde (published Dec 25, 2004), 148 (52), pp. 2579–82, PMID   15646859
  7. Hershko, A.; Ciechanover, A.; Rose, I.A. (1979), "Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP", Proc. Natl. Acad. Sci. USA, 76 (7): 3107–3110, doi:10.1073/pnas.76.7.3107, PMC   383772 , PMID   290989.
  8. - Irwin Rose Autobiography
  9. 1 2 3 Chang, Kenneth (2 June 2015). "Irwin A. Rose, Nobel-Winning Biochemist, Dies at 88". New York Times. Retrieved 4 June 2015.
  11. 1 2 Weil, Martin (3 June 2015). "Irwin Rose, who shared 2004 Nobel Prize in chemistry, dies at 88". Washington Post. Retrieved 4 June 2015.
  12. "Selected Awards and Honors to Penn Faculty and Alumni: Nobel Prizes". University of Pennsylvania Website. Retrieved 4 June 2015.
  13. Hershko, A.; Ciechanover, A.; Heller, H.; Haas, A.L.; Rose, I.A. (1980), "Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis", Proc. Natl. Acad. Sci. USA, 77 (4): 1783–1786, doi:10.1073/pnas.77.4.1783, PMC   348591 , PMID   6990414.
  14. Vogel, Gretchen (2004), "Nobel Prizes. Gold medal from cellular trash", Science (published Oct 15, 2004), 306 (5695), pp. 400–1, doi:10.1126/science.306.5695.400b, PMID   15486272
  15. Nobel citation
  16. Rose Nobel Prize lecture
  17. Giles, Jim (2004), "Chemistry Nobel for trio who revealed molecular death-tag", Nature (published Oct 14, 2004), 431 (7010), p. 729, doi:10.1038/431729a, PMID   15483574
  18. ABC News. "2004 Nobel Chemistry Winner Irwin Rose Dies at 88". ABC News.