Jan Swammerdam

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Jan Swammerdam
Jan Swammerdam.jpg
A 19th-century fantasy portrait, based on the face of Hartman Hartmanzoon from Rembrandt's The Anatomy Lesson of Dr. Nicolaes Tulp . No genuine portrait is known.
Born(1637-02-12)February 12, 1637
DiedFebruary 17, 1680(1680-02-17) (aged 43)
Amsterdam, Dutch Republic
Nationality Dutch
Alma mater University of Leiden
Known forDescribing erythrocytes, work on entomology
Scientific career
Fields Entomology
Influences Antoinette Bourignon

Jan Swammerdam (February 12, 1637 – February 17, 1680) was a Dutch biologist and microscopist. His work on insects demonstrated that the various phases during the life of an insect—egg, larva, pupa, and adult—are different forms of the same animal. As part of his anatomical research, he carried out experiments on muscle contraction. In 1658, he was the first to observe and describe red blood cells. He was one of the first people to use the microscope in dissections, and his techniques remained useful for hundreds of years.

Netherlands Constituent country of the Kingdom of the Netherlands in Europe

The Netherlands is a country located in Northwestern Europe with some overseas territories. In Europe, it consists of 12 provinces that border Germany to the east, Belgium to the south, and the North Sea to the northwest, with maritime borders in the North Sea with those countries and the United Kingdom. Together with three island territories in the Caribbean Sea—Bonaire, Sint Eustatius and Saba—it forms a constituent country of the Kingdom of the Netherlands. The official language is Dutch, but a secondary official language in the province of Friesland is West Frisian.

Larva juvenile form of distinct animals before metamorphosis

A larva is a distinct juvenile form many animals undergo before metamorphosis into adults. Animals with indirect development such as insects, amphibians, or cnidarians typically have a larval phase of their life cycle.

Pupa Life stage of some insects undergoing transformation

A pupa is the life stage of some insects undergoing transformation between immature and mature stages. The pupal stage is found only in holometabolous insects, those that undergo a complete metamorphosis, with four life stages: egg, larva, pupa, and imago. The processes of entering and completing the pupal stage are controlled by the insect's hormones, especially juvenile hormone, prothoracicotropic hormone, and ecdysone.



Swammerdam was baptized on 15 February 1637 in the Oude Kerk Amsterdam. His father was an apothecary, and an amateur collector of minerals, coins, fossils, and insects from around the world. His mother Baertje Jans Corvers died in 1661.[ citation needed ]

Apothecary historical name for a medical professional now called a pharmacist

Apothecary is one term for a medical professional who formulates and dispenses materia medica to physicians, surgeons, and patients. The modern pharmacist has taken over this role. In some languages and regions, the word "apothecary" is still used to refer to a retail pharmacy or a pharmacist who owns one. Apothecaries' investigation of herbal and chemical ingredients was a precursor to the modern sciences of chemistry and pharmacology.

As a youngster Swammerdam had helped his father to take care of his curiosity collection. Despite his father's wish that he should study theology Swammerdam started to study medicine in 1661 at the University of Leiden. He studied under the guidance of Johannes van Horne and Franciscus Sylvius. Among his fellow students were Frederik Ruysch, Reinier de Graaf and Niels Stensen. While studying medicine Swammerdam started his own collection of insects. [1]

Theology is the systematic study of the nature of the divine and, more broadly, of religious belief. It is taught as an academic discipline, typically in universities and seminaries. It occupies itself with the unique content of analyzing the supernatural, but also deals with religious epistemology, asks and seeks to answer the question of revelation. Revelation pertains to the acceptance of God, gods, or deities, as not only transcendent or above the natural world, but also willing and able to interact with the natural world and, in particular, to reveal themselves to humankind. While theology has turned into a secular field, religious adherents still consider theology to be a discipline that helps them live and understand concepts such as life and love and that helps them lead lives of obedience to the deities they follow or worship.

Franciscus Sylvius physician and chemist of Leyden, Netherlands

Franciscus Sylvius, born Franz de le Boë, was a Dutch physician and scientist who was an early champion of Descartes', Van Helmont's and William Harvey's work and theories. He was one of the earliest defenders of the theory of circulation of the blood in the Netherlands, and commonly falsely cited as the inventor of gin, others pin point the origin of Gin to Italy.

Frederik Ruysch Dutch botanist

Frederik Ruysch was a Dutch botanist and anatomist. He is known for developing techniques for preserving anatomical specimens, which he used to create dioramas or scenes incorporating human parts. His anatomical preparations included over 2,000 anatomical, pathological, zoological, and botanical specimens, which were preserved by either drying or embalming. Ruysch is also known for his proof of valves in the lymphatic system, the vomeronasal organ in snakes, and arteria centralis oculi. He was the first to describe the disease that is today known as Hirschsprung's disease, as well as several pathological conditions, including intracranial teratoma, enchondromatosis, and Majewski syndrome.

In 1663 Swammerdam moved to France to continue his studies. He studied one year at the Protestant University of Saumur, under the guidance of Tanaquil Faber. Subsequently, he studied in Paris at the scientific academy of Melchisédech Thévenot. 1665 he returned to the Dutch Republic and joined a group of physicians who performed dissections and published their findings. Between 1666 and 1667 Swammerdam concluded his study of medicine at the University of Leiden. Together with van Horne he researched the anatomy of the uterus. He used wax injection techniques and a single-lense microscope made by Johannes Hudde. The result of this research was published under the title Miraculum naturae sive uteri muliebris fabrica in 1672. Swammerdam received his medical doctor in 1667 under van Horne for his dissertation on the mechanism of respiration, published under the title De respiratione usuque pulmonum. [1]

MelchisédechThévenot was a French author, scientist, traveler, cartographer, orientalist, inventor, and diplomat. He was the inventor of the spirit level and is also famous for his popular 1696 book The Art of Swimming, one of the first books on the subject and widely read during the 18th century. The book popularized the breaststroke. He also influenced the founding of the Académie Royale des Sciences.

Dutch Republic Republican predecessor state of the Netherlands from 1581 to 1795

The United Provinces of the Netherlands, or simply United Provinces, and commonly referred to historiographically as the Dutch Republic, was a confederal republic formally established from the formal creation of a confederacy in 1581 by several Dutch provinces—seceded from Spanish rule—until the Batavian Revolution of 1795. It was a predecessor state of the Netherlands and the first fully independent Dutch nation state.

Uterus major female hormone-responsive reproductive sex organ of most mammals including humans

The uterus or womb is a major female hormone-responsive secondary sex organ of the reproductive system in humans and most other mammals. In the human, the lower end of the uterus, the cervix, opens into the vagina, while the upper end, the fundus, is connected to the fallopian tubes. It is within the uterus that the fetus develops during gestation. In the human embryo, the uterus develops from the paramesonephric ducts which fuse into the single organ known as a simplex uterus. The uterus has different forms in many other animals and in some it exists as two separate uteri known as a duplex uterus.

Research into insects

While studying medicine Swammerdam had started to dissect insects and after qualifying as a doctor, Swammerdam focused studying insects. His father pressured him to earn a living, but Swammerdam persevered and in late 1669 published Historia insectorum generalis ofte Algemeene verhandeling van de bloedeloose dierkens (The General History of Insects, or General Treatise on little Bloodless Animals). The treatise summarised his study of insects he had collected in France and around Amsterdam. He countered the prevailing Aristotelian notion that insects were imperfect animals that lacked internal anatomy. [1] Following the publication his father withdrew all financial support. [2] As a result, Swammerdam was forced, at least occasionally, to practice medicine in order to finance his own research. He obtained leave at Amsterdam to dissect the bodies of those who died in the hospital. [3]

Aristotelianism Tradition in philosophy

Aristotelianism is a tradition of philosophy that takes its defining inspiration from the work of Aristotle. This school of thought, in the modern sense of philosophy, covers existence, ethics, mind and related subjects. In Aristotle's time, philosophy included natural philosophy, which preceded the advent of modern science during the Scientific Revolution. The works of Aristotle were initially defended by the members of the Peripatetic school and later on by the Neoplatonists, who produced many commentaries on Aristotle's writings. In the Islamic Golden Age, Avicenna and Averroes translated the works of Aristotle into Arabic and under them, along with philosophers such as Al-Kindi and Al-Farabi, Aristotelianism became a major part of early Islamic philosophy.

Illustration of a Mosquito from Historia Illustration of a Mosquito from Historia Insectorum Generalis.jpg
Illustration of a Mosquito from Historia

At university Swammerdam engaged deeply in the religious and philosophical ideas of his time. He categorically opposed the ideas behind spontaneous generation, which held that God had created some creatures, but not insects. Swammerdam argued that this would blasphemously imply that parts of the universe were excluded from God's will. In his scientific study Swammerdam tried to prove that God's creation happened time after time, and that it was uniform and stable. Swammerdam was much influenced by René Descartes, whose natural philosophy had been widely adopted by Dutch intellectuals. In Discours de la methode Descartes had argued that nature was orderly and obeyed fixed laws, thus nature could be explained rationally. [4]

Spontaneous generation disproven theory of life arising from nonliving matter

Spontaneous generation refers to an obsolete body of thought on the ordinary formation of living organisms without descent from similar organisms. The theory of spontaneous generation held that living creatures could arise from nonliving matter and that such processes were commonplace and regular. For instance, it was hypothesized that certain forms such as fleas could arise from inanimate matter such as dust, or that maggots could arise from dead flesh. A variant idea was that of equivocal generation, in which species such as tapeworms arose from unrelated living organisms, now understood to be their hosts. The idea of univocal generation, by contrast, refers to effectively exclusive reproduction from genetically related parent(s), generally of the same species.

René Descartes 17th-century French philosopher, mathematician, and scientist

René Descartes was a French philosopher, mathematician, and scientist. A native of the Kingdom of France, he spent about 20 years (1629–1649) of his life in the Dutch Republic after serving for a while in the Dutch States Army of Maurice of Nassau, Prince of Orange and the Stadtholder of the United Provinces. One of the most notable intellectual figures of the Dutch Golden Age, Descartes is also widely regarded as one of the founders of modern philosophy.

Swammerdam was convinced that the creation, or generation, of all creatures obeyed the same laws. Having studied the reproductive organs of men and women at university he set out to study the generation of insects. He had devoted himself to studying insects after discovering that the king bee was indeed a queen bee. Swammerdam knew this because he had found eggs inside the creature. But he did not publish this finding. In 1669 Swammerdam was visited by Cosimo II de' Medici and showed him another revolutionary discovery. Inside a caterpillar the limbs and wings of the butterfly could be seen (now called the imaginal discs). When Swammerdam published The General History of Insects, or General Treatise on little Bloodless Animals later that year he not only did away with the idea that insects lacked internal anatomy, but also attacked the Christian notion that insects originated from spontaneous generation and that their life cycle was a metamorphosis. [5] Swammerdam maintained that all insects originated from eggs and their limbs grew and developed slowly. Thus there was no distinction between insects and so called higher animals. Swammerdam declared war on "vulgar errors" and the symbolic interpretation of insects was, in his mind, incompatible with the power of God, the almighty architect. [6] Swammerdam therefore dispelled the seventeenth-century notion of metamorphosis —the idea that different life stages of an insect (e.g. caterpillar and butterfly) represent different individuals [7] or a sudden change from one type of animal to another. [8]

Miraculum naturae sive uteri muliebris fabrica Miraculum naturae sive uteri muliebris fabrica V00115 00000006.tif
Miraculum naturae sive uteri muliebris fabrica


Swammerdam suffered a crisis of consciousness. Having believed that his scientific research was a tribute to the Creator, he started to fear that he may be worshipping the idol of curiosities. In 1673 Swammerdam briefly fell under the influence of the Flemish mystic Antoinette Bourignon. His 1675 treatise on the mayfly, entitled Ephemeri vita, included devout poetry and documented his religious experiences. [2] Swammerdam found comfort in the arms of Bourignon's sect in Schleswig Holstein, but was back in Amsterdam in early 1676. In a letter to Henry Oldenburg he explained "I was never at any time busier than in these days, and the chief of all architects has blessed my endeavors". [9]

Bybel der natuure

His religious crisis only interrupted his scientific research briefly and until his premature death aged 43 he worked on what was to become his main work. It remained unpublished when he died in 1680 and was published as Bybel der natuure posthumously in 1737 by the Leiden University professor Herman Boerhaave. [10] [11] Convinced that all insects were worth studying, Swammerdam had compiled an epic treatise on as many insects as he could, using the microscope and dissection. Inspired by Marcello Malpighi, in De Bombyce Swammerdam described the anatomy of silkworms, mayflies, ants, stag beetles, cheese mites, bees and many other insects. His scientific observations were infused by the presence of God, the almighty creator. [12] Swammerdam's praise of the louse went on to become a classic:

"Herewith I offer you the Omnipotent Finger of God in the anatomy of a louse: wherein you will find miracle heaped on miracle and see the wisdom of God clearly manifested in a minute point." [4]

Research on bees

Swammerdam's drawing of the queen bee's reproductive organs, as observed through the microscope. Reproductive organs of the bee. Wellcome L0000176.jpg
Swammerdam's drawing of the queen bee's reproductive organs, as observed through the microscope.

In Biblia naturae the first visual proof was published that his contemporaries had mistakenly identified the queen bee as male. [13] Swammerdam also provided evidence that the queen bee is the sole mother of the colony. [14] Swammerdam had engaged in five intense years of beekeeping. He had found that drones were masculine, and had no stinger. Swammerdam identified the worker bees as "natural eunuchs" because he was unable to detect ovaries in them, but described them as nearer to the nature of the female. Swammerdam had produced a drawing of the queen bee's reproductive organs, as observed through the microscope. [15] Since ancient times it had been asserted that the queen bee was male, and ruled the hive. In 1586 Luis Mendez de Torres had first published the finding that the hive was ruled by a female, but Torres had maintained that she produced all other bees in the colony through a "seed". In 1609 Charles Butler had recorded the sex of drones as male, but he wrongly believed that they mated with worker bees. The drawing Swammerdam produced of the internal anatomy of the queen bee was only published 1737. [14] His drawing of the honeycomb geometry was first published in Biblia naturae, but had been referenced by Giacomo Filippo Maraldi in his 1712 book. [16] Details of Swammerdam's research on bees had already been published elsewhere because he had shared his findings with other scientists in correspondence. Among others Swammerdam's research had been referenced by Nicolas Malebranche in 1688. [9]

Research on muscles

Swammerdam's illustration of a nerve-muscle preparation. He placed a frog thigh muscle in a glass syringe with a nerve protruding from a hole in the side of the container. Irritating the nerve caused the muscle to contract, but the level of the water, and thus the volume of the muscle, did not increase. Swammerdam frog thigh.PNG
Swammerdam's illustration of a nerve-muscle preparation. He placed a frog thigh muscle in a glass syringe with a nerve protruding from a hole in the side of the container. Irritating the nerve caused the muscle to contract, but the level of the water, and thus the volume of the muscle, did not increase.

In Biblia Naturae Swammerdam's research on muscles was published. Swammerdam played a key role in the debunking of the balloonist theory, the idea that 'moving spirits' are responsible for muscle contractions. The idea, supported by the Greek physician Galen, held that nerves were hollow and the movement of spirits through them propelled muscle motion. [17] René Descartes furthered the idea by basing it on a model of hydraulics, suggesting that the spirits were analogous to fluids or gasses and calling them 'animal spirits'. [17] In the model, which Descartes used to explain reflexes, the spirits would flow from the ventricles of the brain, through the nerves, and to the muscles to animate the latter. [17] According to this hypothesis, muscles would grow larger when they contract because of the animal spirits flowing into them. To test this idea, Swammerdam placed severed frog thigh muscle in an airtight syringe with a small amount of water in the tip. [17] He could thus determine whether there was a change in the volume of the muscle when it contracted by observing a change in the level of the water (image at right). [17] When Swammerdam caused the muscle to contract by irritating the nerve, the water level did not rise but rather was lowered by a minute amount; this showed that no air or fluid could be flowing into the muscle. [17] The idea that nerve stimulation led to movement had important implications for neuroscience by putting forward the idea that behaviour is based on stimuli. [17]

Swammerdam's research had been referenced before its publication by Nicolas Steno, who had visited Swammerdam in Amsterdam. Swammerdam's research concluded after Steno had published the second edition of Elements of Myology in 1669, which is referenced in Biblia Naturae. [18] A letter from Steno to Malpighi from 1675 suggests that Swammerdam's findings on muscle contraction had caused his crisis of consciousness. Steno sent Malpighi the drawings Swammerdam had done of the experiments, saying "when he had written a treatise on this matter he destroyed it and he has only preserved these figures. He is seeking God, but not yet in the Church of God." [19]


Swammerdam's Historia insectorum generalis was widely known and applauded before he died. Two years after his death in 1680 it was translated into French and in 1685 it was translated into Latin. John Ray, author of the 1705 Historia insectorum, praised Swammerdam' methods, they were "the best of all". [9] Though Swammerdam's work on insects and anatomy was significant, many current histories remember him as much for his methods and skill with microscopes as for his discoveries. He developed new techniques for examining, preserving, and dissecting specimens, including wax injection to make viewing blood vessels easier. A method he invented for the preparation of hollow human organs was later much employed in anatomy. [3] He had corresponded with contemporaries across Europe and his friends Gottfried Wilhelm Leibniz and Nicolas Malebranche used his microscopic research to substantiate their own natural and moral philosophy. [9] But Swammerdam has also been credited with heralding the natural theology of the 18th century, were God's grand design was detected in the mechanics of the solar system, the seasons, snowflakes and the anatomy of the human eye. [9] An English translation of his entomological works by T. Floyd was published in 1758. [3]

No authentic portrait of Jan Swammerdam is extant nowadays. [20] The portrait shown in the header is derived from the painting The Anatomy Lesson of Dr Tulp by Rembrandt and represents the leading Amsterdam physician Hartman Hartmanzoon (1591–1659).


  1. 1 2 3 Klaas Van Berkel, Albert Van Helden & L. C. Palm (1999). The History of Science in the Netherlands: Survey, Themes and Reference. BRILL. p. 570. ISBN   9789004100060.CS1 maint: uses authors parameter (link)
  2. 1 2 Klaas Van Berkel, Albert Van Helden & L. C. Palm (1999). The History of Science in the Netherlands: Survey, Themes and Reference. BRILL. p. 62. ISBN   9789004100060.CS1 maint: uses authors parameter (link)
  3. 1 2 3 Wikisource-logo.svg Ripley, George; Dana, Charles A., eds. (1879). "Swammerdam, Johannes"  . The American Cyclopædia .
  4. 1 2 Karl A. E. Enenkel & Mark S. Smith (2007). Early Modern Zoology: The Construction of Animals in Science, Literature and the Visual Arts. BRILL. p. 160. ISBN   9789047422365.CS1 maint: uses authors parameter (link)
  5. Karl A. E. Enenkel & Mark S. Smith (2007). Early Modern Zoology: The Construction of Animals in Science, Literature and the Visual Arts. BRILL. p. 161. ISBN   9789047422365.CS1 maint: uses authors parameter (link)
  6. Karl A. E. Enenkel & Mark S. Smith (2007). Early Modern Zoology: The Construction of Animals in Science, Literature and the Visual Arts. BRILL. p. 162. ISBN   9789047422365.CS1 maint: uses authors parameter (link)
  7. "...whereas modern biologists speak of the grub, the pupa and the adult as stages in the life cycle of one individual butterfly, Harvey and his contemporaries always regarded the grub as one individual and the butterfly as another."Elizabeth B. Gasking (1966). Investigations Into Generation 1651–1828. Baltimore: The Johns Hopkins University Press. page 30
  8. Matthew Cobb (2006). Generation: The Seventeenth-Century Scientists Who Unraveled the Secrets of Sex, Life, and Growth. New York and London: Bloomsbury. pp. 132–141. ISBN   1-59691-036-4.
  9. 1 2 3 4 5 Karl A. E. Enenkel & Mark S. Smith (2007). Early Modern Zoology: The Construction of Animals in Science, Literature and the Visual Arts. BRILL. p. 165. ISBN   9789047422365.CS1 maint: uses authors parameter (link)
  10. Swammerdam, Jan. 1737-1758. Bybel der natuure . Amsteldammer. Of Historie der insecten
  11. Klaas Van Berkel, Albert Van Helden & L. C. Palm (1999). The History of Science in the Netherlands: Survey, Themes and Reference. BRILL. p. 63. ISBN   9789004100060.CS1 maint: uses authors parameter (link)
  12. Karl A. E. Enenkel & Mark S. Smith (2007). Early Modern Zoology: The Construction of Animals in Science, Literature and the Visual Arts. BRILL. p. 163. ISBN   9789047422365.CS1 maint: uses authors parameter (link)
  13. Tania Munz (2016). The Dancing Bees: Karl Von Frisch and the Discovery of the Honeybee Language. University of Chicago Press. p. 164. ISBN   9780226020860.
  14. 1 2 Eva Crane (1999). The World History of Beekeeping and Honey Hunting. Taylor & Francis. p. 569. ISBN   9780415924672.
  15. Tania Munz (2016). The Dancing Bees: Karl Von Frisch and the Discovery of the Honeybee Language. University of Chicago Press. p. 169. ISBN   9780226020860.
  16. Eva Crane (1999). The World History of Beekeeping and Honey Hunting. Taylor & Francis. p. 564. ISBN   9780415924672.
  17. 1 2 3 4 5 6 7 Cobb M (2002). "Timeline: Exorcizing the animal spirits: Jan Swammerdam on nerve function" (PDF). Nature Reviews Neuroscience. 3 (5): 395–400. doi:10.1038/nrn806. PMID   11988778. Archived from the original (pdf) on 2005-05-15.Cite uses deprecated parameter |deadurl= (help)
  18. Troels Kardel (1994). Steno on Muscles. American Philosophical Society. p. 16. ISBN   9780871698414.
  19. Troels Kardel (1994). Steno on Muscles. American Philosophical Society. p. 17. ISBN   9780871698414.
  20. "Jan Swammerdam's "portrait"" . Retrieved 22 January 2013.

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