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Lesch–Nyhan syndrome (LNS), is a rare inherited disorder caused by a deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT), produced by mutations in the HPRT gene located on the X chromosome. LNS affects about one in 380,000 live births. The disorder was first recognized and clinically characterized by medical student Michael Lesch and his mentor, pediatrician William Nyhan, at Johns Hopkins.
Choreoathetosis is the occurrence of involuntary movements in a combination of chorea and athetosis.
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is an enzyme encoded in humans by the HPRT1 gene.
Odense Boldklub is a Danish professional football club based in the city Odense. The club has won three Danish championships and five Danish Cup trophies. OB play in the Danish Superliga and their home field is Nature Energy Park. OB's clubhouse is located in Ådalen near Odense River.
Jan Leschly is a Danish businessman and former professional tennis player.
William Leo Nyhan is an American physician best known as the co-discoverer of Lesch-Nyhan syndrome.
Phosphoribosyl pyrophosphate (PRPP) is a pentosephosphate.
Nucleic acid metabolism is the process by which nucleic acids are synthesized and degraded. Nucleic acids are polymers of nucleotides. Nucleotide synthesis is an anabolic mechanism generally involving the chemical reaction of phosphate, pentose sugar, and a nitrogenous base. Destruction of nucleic acid is a catabolic reaction. Additionally, parts of the nucleotides or nucleobases can be salvaged to recreate new nucleotides. Both synthesis and degradation reactions require enzymes to facilitate the event. Defects or deficiencies in these enzymes can lead to a variety of diseases.
J(arvis) Edwin Seegmiller, or Jay Seegmiller, was an American physician and biochemical geneticist best known for his role in discovering the biochemical basis of the Lesch-Nyhan syndrome. He was a rheumatologist and a pioneer in research on arthritic diseases and on aging.
Lesse is a commune in the Moselle department in Grand Est in north-eastern France.
Gabriela ("Gabi") Lesch is a retired German runner who specialized in the 800 metres. She represented West Germany at the 1988 Seoul Olympics.
Inborn errors of purine–pyrimidine metabolism are a class of inborn error of metabolism disorders specifically affecting purine metabolism and pyrimidine metabolism. An example is Lesch–Nyhan syndrome.
Klaus-Peter Lesch is a clinical psychiatrist who has been investigating the neurobiological foundation of personality traits.
Harald Lesch is a German physicist, astronomer, natural philosopher, author, television presenter, professor of physics at the Ludwig Maximilian University of Munich (LMU) and professor of natural philosophy at the Munich University of Philosophy. Due to being one of the most influential German science communicators and coming from an astrophysics background, he can be compared to Neil deGrasse Tyson.
Lesh is both a surname and a given name. Notable people with the name include:
Karin Lesch is a Swiss-German stage, cinema, and television actress, of Swiss-Austrian extraction; who hails from a multi-generational family of accomplished German-speaking performers, of theatre and cinema.
Alma Lesch was an American fiber artist known for her fiber portraits. She was "the undisputed grande dame of Kentucky textile arts." A historic marker notes her achievements in Shepherdsville, where Lesch lived and had her studio. Lesch's quilt, Bathshebas Bedspread, was included in the Objects USA exhibit in 1969, which was organized by S.C. Johnson and Son.
Players and pairs who neither have high enough rankings nor receive wild cards may participate in a qualifying tournament held one week before the annual Wimbledon Tennis Championships.
