This is a list of the Irish Recorded Music Association's Irish Singles Chart Top 50 number-ones of 2006.
| Issue date | Song | Artist |
|---|---|---|
| 5 January | "That's My Goal" | Shayne Ward |
| 12 January | ||
| 19 January | ||
| 26 January | ||
| 2 February | ||
| 9 February | ||
| 16 February | ||
| 23 February | "Jumbo Breakfast Roll" | Pat Shortt |
| 2 March | ||
| 9 March | ||
| 16 March | ||
| 23 March | ||
| 30 March | ||
| 6 April | "Crazy" | Gnarls Barkley |
| 13 April | "No Promises" | Shayne Ward |
| 20 April | "Crazy" | Gnarls Barkley |
| 27 April | ||
| 4 May | ||
| 11 May | ||
| 18 May | ||
| 25 May | ||
| 1 June | ||
| 8 June | "I Wish I Was a Punk Rocker (With Flowers in My Hair)" | Sandi Thom |
| 15 June | "Hips Don't Lie" | Shakira featuring Wyclef Jean |
| 22 June | ||
| 29 June | ||
| 6 July | ||
| 13 July | ||
| 20 July | ||
| 27 July | ||
| 3 August | ||
| 10 August | ||
| 17 August | "Everytime We Touch" | Cascada |
| 24 August | ||
| 31 August | "SexyBack" | Justin Timberlake featuring Timbaland |
| 7 September | ||
| 14 September | ||
| 21 September | ||
| 28 September | "Everytime We Touch" | Cascada |
| 5 October | ||
| 12 October | ||
| 19 October | ||
| 26 October | "Irreplaceable" | Beyoncé |
| 2 November | ||
| 9 November | "The Saints Are Coming" | U2 and Green Day |
| 16 November | "The Rose" | Westlife |
| 23 November | "Smack That" | Akon featuring Eminem |
| 30 November | ||
| 7 December | ||
| 14 December | ||
| 21 December | "A Moment Like This" | Leona Lewis |
| 28 December |