This is a list of the Irish Recorded Music Association's Irish Singles Chart Top 50 number-ones of 2006.
| Issue date | Song | Artist | Reference |
|---|---|---|---|
| 5 January | "That's My Goal" | Shayne Ward | [1] |
| 12 January | [2] | ||
| 19 January | [3] | ||
| 26 January | [4] | ||
| 2 February | [5] | ||
| 9 February | [6] | ||
| 16 February | [7] | ||
| 23 February | "Jumbo Breakfast Roll" | Pat Shortt | [8] |
| 2 March | [9] | ||
| 9 March | [10] | ||
| 16 March | [11] | ||
| 23 March | [12] | ||
| 30 March | [13] | ||
| 6 April | "Crazy" | Gnarls Barkley | [14] |
| 13 April | "No Promises" | Shayne Ward | [15] |
| 20 April | "Crazy" | Gnarls Barkley | [16] |
| 27 April | [17] | ||
| 4 May | [18] | ||
| 11 May | [19] | ||
| 18 May | [20] | ||
| 25 May | [21] | ||
| 1 June | [22] | ||
| 8 June | "I Wish I Was a Punk Rocker (With Flowers in My Hair)" | Sandi Thom | [23] |
| 15 June | "Hips Don't Lie" | Shakira featuring Wyclef Jean | [24] |
| 22 June | [25] | ||
| 29 June | [26] | ||
| 6 July | [27] | ||
| 13 July | [28] | ||
| 20 July | [29] | ||
| 27 July | [30] | ||
| 3 August | [31] | ||
| 10 August | [32] | ||
| 17 August | "Everytime We Touch" | Cascada | [33] |
| 24 August | [34] | ||
| 31 August | "SexyBack" | Justin Timberlake featuring Timbaland | [35] |
| 7 September | [36] | ||
| 14 September | [37] | ||
| 21 September | [38] | ||
| 28 September | "Everytime We Touch" | Cascada | [39] |
| 5 October | [40] | ||
| 12 October | [41] | ||
| 19 October | [42] | ||
| 26 October | "Irreplaceable" | Beyoncé | [43] |
| 2 November | [44] | ||
| 9 November | "The Saints Are Coming" | U2 and Green Day | [45] |
| 16 November | "The Rose" | Westlife | [46] |
| 23 November | "Smack That" | Akon featuring Eminem | [47] |
| 30 November | [48] | ||
| 7 December | [49] | ||
| 14 December | [50] | ||
| 21 December | "A Moment Like This" | Leona Lewis | [51] |
| 28 December | [52] |