Louis Siminovitch

Last updated
Louis (Lou) Siminovitch
Louis Siminovitch.JPG
Born (1920-05-15) May 15, 1920 (age 98)
Montreal, Quebec
Occupation molecular biologist
Awards Order of Canada
Order of Ontario
Flavelle Medal (1978)

Louis "Lou" Siminovitch, CC OOnt FRSC FRS (born May 15, 1920) is a Canadian molecular biologist. He was a pioneer in human genetics, researcher into the genetic basis of muscular dystrophy and cystic fibrosis, and helped establish Ontario programs exploring genetic roots of cancer.

Order of Canada order

The Order of Canada is a Canadian national order and the second highest honour for merit in the system of orders, decorations, and medals of Canada. It comes second only to membership in the Order of Merit, which is the personal gift of Canada's monarch.

Order of Ontario order

The Order of Ontario is the most prestigious official honour in the Canadian province of Ontario. Instituted in 1986 by Lieutenant Governor Lincoln Alexander, on the advice of the Cabinet under Premier David Peterson, the civilian order is administered by the Lieutenant Governor-in-Council and is intended to honour current or former Ontario residents for conspicuous achievements in any field.

Fellowship of the Royal Society of Canada (FRSC) is an award granted to individuals that the Royal Society of Canada judges to have "made remarkable contributions in the arts, the humanities and the sciences, as well as in Canadian public life".


Born in Montreal, Quebec to parents who had emigrated from Eastern Europe, he won a scholarship in chemistry to McGill University, earning a doctorate in 1944. He then studied at the Pasteur Institute in Paris. In 1953 he joined Toronto's Connaught Medical Research Laboratories. Later he joined the University of Toronto and worked there from 1956 to 1985. One of his doctoral students was Joyce Taylor-Papadimitriou.

Montreal City in Quebec, Canada

Montreal is the most populous municipality in the Canadian province of Quebec and the second-most populous municipality in Canada. Originally called Ville-Marie, or "City of Mary", it is named after Mount Royal, the triple-peaked hill in the heart of the city. The city is centred on the Island of Montreal, which took its name from the same source as the city, and a few much smaller peripheral islands, the largest of which is Île Bizard. It has a distinct four-season continental climate with warm to hot summers and cold, snowy winters.

Quebec Province of Canada

Quebec is one of the thirteen provinces and territories of Canada. It is bordered to the west by the province of Ontario and the bodies of water James Bay and Hudson Bay; to the north by Hudson Strait and Ungava Bay; to the east by the Gulf of Saint Lawrence and the province of Newfoundland and Labrador; and to the south by the province of New Brunswick and the U.S. states of Maine, New Hampshire, Vermont, and New York. It also shares maritime borders with Nunavut, Prince Edward Island, and Nova Scotia. Quebec is Canada's largest province by area and its second-largest administrative division; only the territory of Nunavut is larger. It is historically and politically considered to be part of Central Canada.

McGill University English-language university in Montreal, Quebec

McGill University is a public research university in Montreal, Quebec, Canada. It was established in 1821 by royal charter, granted by King George IV. The university bears the name of James McGill, a Montreal merchant originally from Scotland whose bequest in 1813 formed the university's precursor, McGill College.

He helped establish the Department of Genetics at the Hospital for Sick Children as geneticist in chief, where he worked from 1970 to 1985. From 1983 to 1994 he was the founding director of research at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital (Toronto).

Mount Sinai Hospital (MSH) is a hospital in Toronto, Ontario, Canada. Mount Sinai is the main hospital of the Sinai Health System, although it is linked by bridges and tunnels to three adjacent hospitals of the University Health Network. During the 2005 annual charity, the hospital reported to the Canada Revenue Agency as having assets of roughly C$ 520 million.

He is the author or coauthor, at last count, of over 147 scientific papers, reviews, and articles in journals and books.

He married Elinore, a playwright who died in 1995. They had three daughters. The annual Elinore & Lou Siminovitch Prize in Theatre is named in his and his wife's honour.

The Siminovitch Prize in Theatre is given to recognize achievement in Canadian theatre; specifically, professional directors, playwrights and designers in three-year cycles. The prize was launched in 2000 to honour the values and achievements of the distinguished scientist Louis ("Lou") Siminovitch and his late wife Elinore Siminovitch who was a pioneering playwright. A group of Dr. Siminovitch’s friends and colleagues came together on the occasion of his 80th birthday to create this award which is national, bi-lingual, and juried by theatre professionals.



Royal Society of Canada academy in Canada

The Royal Society of Canada, also known as the Academies of Arts, Humanities and Sciences of Canada, is the senior national, bilingual council of distinguished Canadian scholars, humanists, scientists and artists. The primary objective of the RSC is to promote learning and research in the arts, the humanities and the sciences. The RSC is Canada’s National Academy and exists to promote Canadian research and scholarly accomplishment in both official languages, to recognize academic and artistic excellence, and to advise governments, non-governmental organizations and Canadians on matters of public interest.

The Canadian Centennial Medal is a commemorative medal struck by the Royal Canadian Mint in 1967 to commemorate the 100th anniversary of the Canadian Confederation and was awarded to Canadians who were recommended by governments and professional, educational and cultural associations, as well as military and protective services, veterans' groups, sports associations, and philanthropic and charitable bodies, for having provided valuable service to Canada. Some 29,500 medals were issued after its inauguration on 1 July 1967, of which 8,500 went to personnel in the Canadian Forces.

Queen Elizabeth II Silver Jubilee Medal

The Queen Elizabeth II Silver Jubilee Medal was a commemorative medal created in 1977 to mark the twenty-fifth anniversary of Elizabeth II's accession in the United Kingdom, Canada, Australia, and New Zealand. The medal was physically identical in all realms where it was awarded, save for Canada, where it contained unique elements. As an internationally distributed award, the Queen Elizabeth II Silver Jubilee Medal holds a different place in each country's order of precedence for honours.

Related Research Articles

Frederick Banting Canadian medical scientist and doctor

Sir Frederick Grant Banting was a Canadian medical scientist, physician, painter, and Nobel laureate noted as the co-discoverer of insulin and its therapeutic potential.

University of Toronto Faculty of Medicine medical school of the University of Toronto, Canada

The University of Toronto Faculty of Medicine is the medical school of the University of Toronto. The faculty is based in the Discovery District of Downtown Toronto along with most of its teaching hospitals and research institutes. Founded in 1843, it is one of Canada's oldest institutions of medical studies, and is known for the discovery of insulin and stem cells. The school was ranked 5th in the world and 1st in Canada by the U.S. News and World Education Rankings for Clinical Medicine in 2018, and 11th in the world and 1st in Canada by the QS University Subject Rankings for Medicine in 2018.

Paul Douglas Axelrod is a Professor Emeritus, Faculty of Education at York University, of which he was dean from 2001-2008. He has written widely on the history and political economy of schooling and higher education. Born in London, Ontario, he received a B.A. in history and political science from York University in 1972, an M.A. in History from the University of Toronto in 1973, and a doctorate in history from York in 1980. Before arriving at York in 1982, he taught at Queen's University.

Anthony Pawson British-Canadian scientist

Anthony "Tony" James Pawson,, was a British-born Canadian scientist whose research has revolutionised the understanding of signal transduction, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other. He identified the phosphotyrosine-binding Src homology 2 as the prototypic non-catalytic interaction module. SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signalling. Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins.

James Edgar Till, is a University of Toronto biophysicist, best known for demonstrating – with Ernest McCulloch – the existence of stem cells.

The Ontario Cancer Institute (OCI) is the research division of Princess Margaret Cancer Centre, affiliated to the University Health Network of the University of Toronto Faculty of Medicine. As Canada's first dedicated cancer hospital, it opened officially and began to receive patients in 1958, although its research divisions had begun work a year earlier. Because, at that time, a stigma was associated with the word "cancer", the hospital was soon renamed the Princess Margaret Hospital, although the whole operation was called the Ontario Cancer Institute incorporating the Princess Margaret Hospital, or OCI/PMH. Clinicians usually preferred the hospital name, while the scientists used OCI.

Ernest Armstrong McCulloch, was a University of Toronto cellular biologist, best known for demonstrating – with James Till – the existence of stem cells.

Tak Wah Mak, is a Canadian medical researcher, geneticist, oncologist, and biochemist. He first became widely known for his discovery of the T-cell receptor in 1983 and pioneering work in the genetics of immunology. In 1995, Mak published a landmark paper on the discovery of the function of the immune checkpoint protein CTLA-4, thus opening the path for immunotherapy/checkpoint inhibitors as a means of cancer treatment. Mak is also the founder of Agios Pharmaceuticals, whose lead compound, IDHIFA®, was approved by the FDA for Acute myeloid leukemia in August 2017, becoming the first drug specifically targeting cancer metabolism to be used for cancer treatment. He has worked in a variety of areas including biochemistry, immunology, and cancer genetics. His ground breaking work on the T-cell receptor has been postulated to be in consideration for a Nobel prize.

Donald Harman Akenson is a historian and author. He is widely acknowledged as the world's foremost expert in the history of worldwide Irish migration. Notably prolific, he has written at least 23 book-length, scholarly monographs, 3 jointly-authored scholarly books, 6 works of fiction and historical fiction, and 55 scholarly articles. He is a Fellow of both the Royal Society of Canada and the Royal Historical Society (UK). He is also a Molson Prize Laureate, awarded for a lifetime contribution to Canadian culture. He was awarded a Guggenheim Fellowship in 1984, and in 1992 he won the prestigious Grawemeyer Award, then the richest non-fiction book prize in the world. Akenson received his B.A. from Yale University and his doctorate from Harvard University. He is Douglas Professor of History at Queen's University in Kingston, Ontario, Canada and was simultaneously Beamish Research Professor at the Institute of Irish Studies, University of Liverpool (2006–10), and Senior Editor of the McGill-Queen's University Press (1982-2012).

Lunenfeld-Tanenbaum Research Institute

The Lunenfeld-Tanenbaum Research Institute is a medical research institute in Toronto, Ontario and part of the Sinai Health System. It was originally established in 1985 as the Samuel Lunenfeld Research Institute, the research arm of Mount Sinai Hospital, by an endowment from the Lunenfeld and Kunin families. It was renamed to the current name on June 24, 2013 after a $35 million donation from Larry and Judy Tanenbaum.

Brigitte Haentjens, is a Canadian theatre director and president of her own company, Sybillines, which she founded in 1997. She is currently the Artistic Director at Canada's National Arts Centre French Theatre in Ottawa.

Michael Grunstein biologist from United States of America

Michael Grunstein is a Distinguished Professor Emeritus of Biological Chemistry at the David Geffen School of Medicine at UCLA.

This article outlines the history of natural scientific research in Canada, including physics, astronomy, space science, geology, oceanography, chemistry, biology, and medical research. Neither the social sciences nor the formal sciences are treated here.

The Canadian Science and Engineering Hall of Fame, located at the Canada Science and Technology Museum in Ottawa, Ontario, honours Canadians who have made outstanding contributions to society in science and engineering. It also promotes role models to encourage young Canadians to pursue careers in science, engineering and technology. The hall includes a permanent exhibition, a traveling exhibition, a virtual gallery, and events and programming to celebrate inductees.

Alan Bernstein, is President and CEO of the Canadian Institute for Advanced Research.

Till & McCulloch are James Till and Ernest McCulloch who, while studying the effect of radiation on the bone marrow of mice at the Ontario Cancer Institute, in Toronto, demonstrated the existence of multipotent stem cells in 1961.

Andras Nagy

Andras Nagy is a research scientist at the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital in Toronto, Ontario. He heads a team of 50 researchers on Project Grandiose, who study the process of creating stem cells. Nagy holds a Canadian Research Chair in stem cells and regeneration.

Demetrios A. Spandidos is a Greek virologist and cancer researcher. He is an emeritus professor at the University of Crete where he was professor of virology from 1989 till 2015. He is also the founder of Spandidos Publications and the editor-in-chief of all eight of its journals.


Selected publications