Mondor's disease

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Mondor's disease
Other namesMondor's syndrome of superficial thrombophlebitis [1]
Enfermedad de Mondor (RPS 07-12-2021) cordon subcutaneo en costado izquierdo del torax.png
Mondor's disease on subcutaneous cord on the left side of the thorax
Specialty Family medicine   OOjs UI icon edit-ltr-progressive.svg

Mondor's disease is a rare condition which involves thrombophlebitis of the superficial veins of the breast and anterior chest wall. It sometimes occurs in the arm or penis. [2] [3] In axilla, this condition is known as axillary web syndrome. [4]

Contents

Patients with this disease often have abrupt onset of superficial pain, with possible swelling and redness of a limited area of their anterior chest wall or breast. There is usually a lump present, which may be somewhat linear and tender. Because of the possibility of the lump being from another cause, patients are often referred for mammogram and/or breast ultrasound. [5]

Blood clot seen on ultrasound of the dorsal penile vein [6]

Mondor's disease is self-limiting and generally benign. A cause is often not identified, but when found includes trauma, surgery, or inflammation such as infection. There have been occasional cases of associated cancer. [7] Management is with warm compresses and pain relievers, most commonly NSAIDS such as ibuprofen. When thrombophlebitis affects the greater veins, it can progress into the deep venous system, and may lead to pulmonary embolism. [8]

The condition is named after Henri Mondor (1885–1962), a surgeon in Paris, France who first described the disease in 1939. [9]

See also

Related Research Articles

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<span class="mw-page-title-main">Great saphenous vein</span>

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<span class="mw-page-title-main">Tietze syndrome</span> Inflammation, tenderness, and pain of the chest wall with swelling present

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<span class="mw-page-title-main">Paget–Schroetter disease</span> Medical condition

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<span class="mw-page-title-main">May–Thurner syndrome</span> Medical condition

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<span class="mw-page-title-main">Fibrocystic breast changes</span> Medical condition

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<span class="mw-page-title-main">Chronic venous insufficiency</span> Medical condition

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<span class="mw-page-title-main">Henri Mondor</span>

Henri Mondor was a French physician, surgeon, and a historian of French literature and medicine.

<span class="mw-page-title-main">Superficial thrombophlebitis</span> Medical condition

Superficial thrombophlebitis is a thrombosis and inflammation of superficial veins which presents as a painful induration with erythema, often in a linear or branching configuration forming cords.

Pseudothrombophlebitis is a clinical condition where there are signs and symptoms of phlebitis in the absence of a thrombophlebitis lesion. Symptoms include pain, swelling, erythema and tenderness evolving over hours or days. It is often associated with the rupture or dissection of a popliteal cyst otherwise known as a Baker's cyst, although it can be associated with other disorders such as the arthritides. It may also occur as an orthopaedic surgical complication, secondary to trauma or as a presentation of septic arthritis. It is crucial to differentiate this condition from deep vein thrombosis as the treatment for DVT can cause adverse effects in patients with pseudothrombophlebitis.

<span class="mw-page-title-main">Hughes–Stovin syndrome</span> Medical condition

Hughes–Stovin Syndrome (HSS) is a rare autoimmune disorder often described as inflammation in relation to blood vessels, a form of vasculitis. It is not associated with any known cause and is typically characterized by multiple pulmonary artery aneurysms and deep vein thromboses. It is named after the two British physicians, John Patterson Hughes and Peter George Ingle Stovin, who first described it in 1959. HSS is presumed to be a rare variant of Behçet's disease, which entails more general problems with the circulatory system. Due to its clinical similarity with Behçet's disease, it has also been referred to as 'Incomplete Behçet's disease.' Most patients are young adult males between the age of 20–40. Common clinical presentations include fever, cough, dyspnea and hemoptysis. Radiological features are similar to those of Behçet's disease.

Septic pelvic thrombophlebitis (SPT), also known as suppurative pelvic thrombophlebitis, is a rare postpartum complication which consists of a persistent postpartum fever that is not responsive to broad-spectrum antibiotics, in which pelvic infection leads to infection of the vein wall and intimal damage leading to thrombogenesis in the ovarian veins. The thrombus is then invaded by microorganisms. Ascending infections cause 99% of postpartum SPT.

<span class="mw-page-title-main">Superficial vein thrombosis</span> Medical condition

Superficial vein thrombosis (SVT) is a blood clot formed in a superficial vein, a vein near the surface of the body. Usually there is thrombophlebitis, which is an inflammatory reaction around a thrombosed vein, presenting as a painful induration with redness. SVT itself has limited significance when compared to a deep vein thrombosis (DVT), which occurs deeper in the body at the deep venous system level. However, SVT can lead to serious complications, and is therefore no longer regarded as a benign condition. If the blood clot is too near the saphenofemoral junction there is a higher risk of pulmonary embolism, a potentially life-threatening complication.

References

  1. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN   978-1-4160-2999-1.[ page needed ]
  2. James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 827. ISBN   978-0-7216-2921-6.
  3. "Penile Mondor's Disease (PMD)". umiamihealth.org. Retrieved 2023-01-06.
  4. Shoham Y, Rosenberg N, Krieger Y, Silberstein E, Arnon O, Bogdanov-Berezovsky A (December 2011). "[Axillary web syndrome—a variant of Mondor's disease, following excision of an accessory breast]". Harefuah (in Hebrew). 150 (12): 893–4, 937, 936. PMID   22352279.
  5. Shetty MK, Watson AB (October 2001). "Mondor's disease of the breast: sonographic and mammographic findings". American Journal of Roentgenology. 177 (4): 893–6. doi:10.2214/ajr.177.4.1770893. PMID   11566698.
  6. "UOTW #43 - Ultrasound of the Week". Ultrasound of the Week. 2 April 2015. Retrieved 27 May 2017.
  7. Catania S, Zurrida S, Veronesi P, Galimberti V, Bono A, Pluchinotta A (May 1992). "Mondor's disease and breast cancer". Cancer. 69 (9): 2267–70. doi:10.1002/1097-0142(19920501)69:9<2267::aid-cncr2820690910>3.0.co;2-u. hdl: 2434/892627 . PMID   1562972. S2CID   38025663.
  8. Menesez, Nelson. "Superficial thrombophebitis". MedScape. Retrieved 28 August 2012.
  9. Henri Mondor: Tronculite sous-cutanée subaiqure de la paroi thoracique antero-laterale, In: Mem. Acad. Chir. 1271, 1939