Mortimer's disease

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Mortimer's disease
Classification and external resources

Mortimer's disease is a skin disease characterized by red blotchy patterns appearing all over the face and hands, and spreading through the body in an almost symmetrical pattern. The fact that there are no ulcers, and an absence of crust, indicate that this is a different entity than lupus vulgaris. The disease was originally documented by Jonathan Hutchinson (1828-1913), and became an eponym after his patient, Mrs. Mortimer.

Skin soft outer covering organ of vertebrates

Skin is the soft outer tissue covering of vertebrates with three main functions: protection, regulation, and sensation.

Ulcer (dermatology) type of cutaneous condition

An ulcer is a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. Ulcers can result in complete loss of the epidermis and often portions of the dermis and even subcutaneous fat. Ulcers are most common on the skin of the lower extremities and in the gastrointestinal tract. An ulcer that appears on the skin is often visible as an inflamed tissue with an area of reddened skin. A skin ulcer is often visible in the event of exposure to heat or cold, irritation, or a problem with blood circulation. They can also be caused due to a lack of mobility, which causes prolonged pressure on the tissues. This stress in the blood circulation is transformed to a skin ulcer, commonly known as bedsores or decubitus ulcers. Ulcers often become infected, and pus forms.

Lupus vulgaris Human disease

Lupus vulgaris are painful cutaneous tuberculosis skin lesions with nodular appearance, most often on the face around the nose, eyelids, lips, cheeks, ears and neck. It is the most common Mycobacterium tuberculosis skin infection. The lesions may ultimately develop into disfiguring skin ulcers if left untreated.

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The Frei test was developed in 1925 by Wilhelm Siegmund Frei, a German dermatologist, to identify lymphogranuloma venereum. Antigen made from sterile pus aspirated from previously unruptured abscesses, produced a reaction in patients with lymphogranuloma venereum when injected intradermally. Other sources of antigen have been explored, most deriving from various tissues of mice infected with Chlamydia. The test is no longer used but stands as a milestone in our understanding of immunology. A heat inactivated LGV 0.1ml grown in yolk sac of embryonated egg is injected intra dermally on the forearm and a control material prepared from noninfected yolk sac on the other forearm i.e. control. After 48–72 hours, an inflammatory nodule more than 6mm in diameter develops at the test site.

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