The Moser research environment (Norwegian : Moser-miljøet) is the informal name of a research environment established and led by the Nobel laureates Edvard Moser and May-Britt Moser at the Norwegian University of Science and Technology (NTNU) in Trondheim, Norway. The Mosers joined the university as professors of psychology in 1996, and formed their own neuroscience research group. The research group eventually evolved into several projects and research centers. The Mosers were awarded the 2014 Nobel Prize in Physiology or Medicine "for their discoveries of cells that constitute a positioning system in the brain." [1]
The Moser research environment was established in 1996 as the neuroscience research group and laboratory of the Mosers at the Department of Psychology, NTNU. In 2002 their research group was given the status of a centre of excellence by the Research Council of Norway, and thus became a separate entity under the name Centre for the Biology of Memory (CBM), with government funding for ten years. The discovery of "grid cells" was made at CBM in 2005; [2] [3] the Mosers received the Nobel Prize in Physiology or Medicine for this discovery in 2014 together with John O'Keefe.
In 2012 the Research Council of Norway granted the Mosers another centre of excellence, known as the Centre for Neural Computation (Norwegian : Senter for nevrale nettverk). CMB was later continued as the Kavli Institute for Systems Neuroscience. [3] The institute is also popularly known as the Moser Institute. [4]
The stated scientific goal is "to advance our understanding of neural circuits and systems and their role in generating psychological functions. By focusing on spatial representation and memory, we expect to uncover general principles of neural network computation in the mammalian cortex." [3]
The Moser research environment receives more than 90% of its funding from the Norwegian government. This includes centres of excellence funded by the Research Council of Norway, support from the university's own budget, and an annual major basic research grant from the government. The research environment has received smaller private donations; in 2007 CMB received an additional donation from the Kavli Foundation in the United States, and it has also received a donation by heiress Pauline Braathen. After the CBM funding expired in 2012, the Research Council of Norway appointed a new Centre of Excellence at the institute with funding until 2022, thus establishing the Centre for Neural Computation (CNC) in January 2013. [3] The CNC co-exists with the institute which complements the shorter-term projects at CBM/CNC, pursuing questions that demand a longer experimental time frame, aimed, ultimately, "to improve life and health by advancing the science of human cognition". [2]
The institute is headed by Edvard Moser while May-Britt Moser heads the CNC centre. Other professors at the Institute are Menno Witter, Clifford Kentros, Yasser Roudi and Emre Yaksi.
The entorhinal cortex (EC) is an area of the brain's allocortex, located in the medial temporal lobe, whose functions include being a widespread network hub for memory, navigation, and the perception of time. The EC is the main interface between the hippocampus and neocortex. The EC-hippocampus system plays an important role in declarative (autobiographical/episodic/semantic) memories and in particular spatial memories including memory formation, memory consolidation, and memory optimization in sleep. The EC is also responsible for the pre-processing (familiarity) of the input signals in the reflex nictitating membrane response of classical trace conditioning; the association of impulses from the eye and the ear occurs in the entorhinal cortex.
Cognitive neuroscience is the scientific field that is concerned with the study of the biological processes and aspects that underlie cognition, with a specific focus on the neural connections in the brain which are involved in mental processes. It addresses the questions of how cognitive activities are affected or controlled by neural circuits in the brain. Cognitive neuroscience is a branch of both neuroscience and psychology, overlapping with disciplines such as behavioral neuroscience, cognitive psychology, physiological psychology and affective neuroscience. Cognitive neuroscience relies upon theories in cognitive science coupled with evidence from neurobiology, and computational modeling.
The Norwegian University of Science and Technology is a public university in Norway and the largest university by enrollment in the country. The university's headquarters campus is located in Trondheim, with regional campuses in Gjøvik and Ålesund.
Fred Kavli was a Norwegian-American businessman and philanthropist. He was born on a small farm in Eresfjord, Norway. He founded the Kavlico Corporation, located in Moorpark, California. Under his leadership, the company became one of the world's largest suppliers of sensors for aeronautic, automotive, and industrial applications supplying General Electric and the Ford Motor Company.
A neuroscientist is a scientist who has specialised knowledge in neuroscience, a branch of biology that deals with the physiology, biochemistry, psychology, anatomy and molecular biology of neurons, neural circuits, and glial cells and especially their behavioral, biological, and psychological aspect in health and disease.
A grid cell is a type of neuron within the entorhinal cortex that fires at regular intervals as an animal navigates an open area, allowing it to understand its position in space by storing and integrating information about location, distance, and direction. Grid cells have been found in many animals, including rats, mice, bats, monkeys, and humans.
The Kavli Foundation, based in Los Angeles, California, is a foundation that supports the advancement of science and the increase of public understanding and support for scientists and their work.
Edvard Ingjald Moser is a Norwegian psychologist and neuroscientist, who is a professor at the Norwegian University of Science and Technology (NTNU) in Trondheim. In 2005, he and his then-wife May-Britt Moser discovered grid cells in the brain's medial entorhinal cortex. Grid cells are specialized neurons that provide the brain with a coordinate system and a metric for space. In 2018, he discovered a neural network that expresses your sense of time in experiences and memories] located in the brain's lateral entorhinal cortex.
May-Britt Moser is a Norwegian psychologist and neuroscientist, who is a Professor of Psychology and Neuroscience at the Norwegian University of Science and Technology (NTNU). She and her then-husband, Edvard Moser, shared half of the 2014 Nobel Prize in Physiology or Medicine, awarded for work concerning the grid cells in the entorhinal cortex, as well as several additional space-representing cell types in the same circuit that make up the positioning system in the brain. Together with Edvard Moser she established the Moser research environment at NTNU, which they lead. Since 2012 she has headed the Centre for Neural Computation.
The Onsager Medal (Onsagermedaljen) is a scholastic presentation awarded to researchers in one or more subject areas of chemistry, physics or mathematics. The medal is awarded in memory of Lars Onsager who received Nobel Prize in Chemistry in 1968. The medal, designed by Harald Wårvik, commemorates the efforts of a single individual as chosen by the Onsager committee at the Norwegian University of Science and Technology (NTNU). The professorship awardee is expected to spend 3–6 months working at NTNU. The lectureship awardee will give a lecture at the university.
The W. Alden Spencer Award is awarded to an investigator in recognition of outstanding research contributions by the College of Physicians and Surgeons, the Department of Neuroscience, and The Kavli Institute for Brain Science at Columbia University. It is named after W. Alden Spencer, a Professor of Physiology and Neurology at Columbia University. The award winner also gives a lecture. In 2018, it took place at on October 9, 2018.
John O'Keefe, is an American-British neuroscientist, psychologist and a professor at the Sainsbury Wellcome Centre for Neural Circuits and Behaviour and the Research Department of Cell and Developmental Biology at University College London. He discovered place cells in the hippocampus, and that they show a specific kind of temporal coding in the form of theta phase precession. He shared the Nobel Prize in Physiology or Medicine in 2014, together with May-Britt Moser and Edvard Moser; he has received several other awards. He has worked at University College London for his entire career, but also held a part-time chair at the Norwegian University of Science and Technology at the behest of his Norwegian collaborators, the Mosers.
The Karl Spencer Lashley Award is awarded by The American Philosophical Society as a recognition of research on the integrative neuroscience of behavior. The award was established in 1957 by a gift from Dr. Karl Spencer Lashley.
The Perl-UNC Prize is awarded internationally in the field of neuroscience. Its purpose is two-fold: to recognize researchers for outstanding discoveries and seminal insights in neuroscience and to celebrate the strength of the neuroscience research program at the University of North Carolina at Chapel Hill.
The Department of Psychology at the University of Oslo is the oldest and largest research institute and educational institution in psychology in Norway. It is Norway's main research institution in clinical psychology, cognitive psychology, developmental psychology, personality psychology, and social and cultural psychology, and one of the main research environments in neuroscience. The institute is located in the Harald Schjelderup Building adjacent to Oslo University Hospital, Rikshospitalet in the Gaustad area of Oslo; the building is shared with parts of the Faculty of Medicine, while Oslo University Hospital occupies surrounding buildings. The institute's alumni include two Nobel laureates, Edvard Moser and May-Britt Moser.
Audrey van der Meer is a Dutch-born Norwegian neuroscientist and Professor of Neuropsychology at the Department of Psychology at the Norwegian University of Science and Technology (NTNU). With her husband, Professor of Cognitive Psychology Ruud van der Weel, she directs the Developmental Neuroscience Laboratory at NTNU. Her research seeks to understand the underlying principles that guide development, learning, and cognitive ageing. She joined the psychology department at NTNU in 1996, in the same year fellow neuroscientists Edvard Moser and May-Britt Moser joined the department; in 1997 she was promoted to full professor of neuroscience. She was part of the Section for Biological Psychology headed by Edvard Moser, but had her own research group. She is a member of the Royal Norwegian Society of Sciences and Letters.
Tim P. Vogels is a professor of theoretical neuroscience and research leader at the Institute of Science and Technology Austria. He is primarily known for his scholarly contributions to the study of neuronal plasticity related to learning and memory in the brain.
Lisa Giocomo is an American neuroscientist who is associate professor in the Department of Neurobiology at Stanford University School of Medicine. Giocomo probes the molecular and cellular mechanisms underlying cortical neural circuits involved in spatial navigation and memory.
Alexander Mathis is an Austrian mathematician, computational neuroscientist and software developer. He is currently an assistant professor at the École polytechnique fédérale de Lausanne (EPFL) in Switzerland. His research interest focus on research at the intersection of computational neuroscience and machine learning.
Ole Jensen is a Danish neuroscientist and professor of translational neuroscience at the School of Psychology, University of Birmingham. He is known for his research work on applying magnetoencephalography to study the functioning of human brain.
Kavli-instituttet, også godt kjent som Moser-instituttet