Paul Hermann Müller

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Paul Hermann Müller
Paul Hermann Muller nobel.jpg
Born(1899-01-12)12 January 1899
Died12 October 1965(1965-10-12) (aged 66)
Nationality Swiss
Alma mater Universität Basel
Known forInsecticidal applications of DDT
Awards Nobel Prize in Physiology or Medicine (1948)
Scientific career
Fields Chemistry
Institutions J. R. Geigy AG
Doctoral advisor Hans Rupe

Paul Hermann Müller also known as Pauly Mueller (12 January 1899 – 13 October 1965) was a Swiss chemist who received the 1948 Nobel prize in Physiology or Medicine for his 1939 discovery of insecticidal qualities and use of DDT in the control of vector diseases such as malaria and yellow fever.

The Swiss are the citizens of Switzerland or people of Swiss ancestry.

Chemist Scientist trained in the study of chemistry

A chemist is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe the properties they study in terms of quantities, with detail on the level of molecules and their component atoms. Chemists carefully measure substance proportions, reaction rates, and other chemical properties. The word 'chemist' is also used to address Pharmacists in Commonwealth English.

DDT Organochloride known for its insecticidal properties

Dichlorodiphenyltrichloroethane, commonly known as DDT, is a colorless, tasteless, and almost odorless crystalline chemical compound, an organochlorine, originally developed as an insecticide, and ultimately becoming infamous for its environmental impacts. It was first synthesized in 1874 by the Austrian chemist Othmar Zeidler. DDT's insecticidal action was discovered by the Swiss chemist Paul Hermann Müller in 1939. DDT was used in the second half of World War II to control malaria and typhus among civilians and troops. Müller was awarded the Nobel Prize in Physiology or Medicine "for his discovery of the high efficiency of DDT as a contact poison against several arthropods" in 1948.

Contents

Early life and education

Müller was born on January 12, 1899 in Olten, Solothurn to Gottlieb and Fanny (née Leypoldt or Leypold [1] ) Müller. [2] He was the oldest of four children. [1] His father worked for the Swiss Federal Railways and the family first moved to Lenzburg in Aargau and then to Basel.

Olten Place in Solothurn, Switzerland

Olten is a town in the canton of Solothurn in Switzerland and capital of the district of the same name.

Solothurn Place in Switzerland

Solothurn is a town, a municipality, and the capital of the canton of Solothurn in Switzerland. It is located in the north-west of Switzerland on the banks of the Aare and on the foot of the Weissenstein Jura mountains.

Swiss Federal Railways national railway company of Switzerland

Swiss Federal Railways is the national railway company of Switzerland. It is usually referred to by the initials of its German, French, and Italian names, either as SBB CFF FFS, or used separately. The Romansh version of its name, Viafiers federalas svizras, is not officially used.

Müller went to the "Freie Evangelische Volksschule" (free Protestant peoples school) and later to the lower and upper "Realschule". [1] In that time, he had a small laboratory where he could develop photographic plates or build radio equipment. [1]

In 1916 he left school to work as a laboratory assistant at Dreyfus (or Dreyfuss & Cie [1] ) and Company; the next year he became an assistant chemist in the Scientific-Industrial Laboratory of the electrical plant of Lonza A.G. Returning to school in 1918, he obtained his diploma by 1919 and entered Basel University in the same year.

At Basel University he studied chemistry (with a minor in botany and physics [1] ) and started to study inorganic chemistry under professor Friedrich Fichter. In 1922 he continued his studies in the organic chemistry lab of Hans Rupe. [1] While working for Rupe as assistant, he received his PhD writing a dissertation entitled Die chemische und elektrochemische Oxidation des as. m-Xylidins und seines Mono- und Di-Methylderivates (The Chemical and Electrochemical Oxidation of Asymmetrical m-Xylidene and its Mono- and Di-methyl Derivatives) in 1925. [2] [3] He graduated with summa cum laude. [1]

Botany science of plant life

Botany, also called plant science(s), plant biology or phytology, is the science of plant life and a branch of biology. A botanist, plant scientist or phytologist is a scientist who specialises in this field. The term "botany" comes from the Ancient Greek word βοτάνη (botanē) meaning "pasture", "grass", or "fodder"; βοτάνη is in turn derived from βόσκειν (boskein), "to feed" or "to graze". Traditionally, botany has also included the study of fungi and algae by mycologists and phycologists respectively, with the study of these three groups of organisms remaining within the sphere of interest of the International Botanical Congress. Nowadays, botanists study approximately 410,000 species of land plants of which some 391,000 species are vascular plants, and approximately 20,000 are bryophytes.

Physics Study of the fundamental properties of matter and energy

Physics is the natural science that studies matter, its motion, and behavior through space and time, and that studies the related entities of energy and force. Physics is one of the most fundamental scientific disciplines, and its main goal is to understand how the universe behaves.

Friedrich Fichter Swiss chemist

Friedrich Fichter was a professor of inorganic chemistry at the University of Basel. His main field of interest was electrochemistry. He initiated the founding of the scientific journal Helvetica Chimica Acta.

Early work at Geigy

On 25 May 1925 [1] Müller began working as a research chemist for the dye division of J. R. Geigy AG in Basel. His first research topics at Geigy concerned synthetic and plant-derived dyes and natural tanning agents. This work led to the production of the synthetic tanning agents Irgatan G, Irgatan FL and Irgatan FLT. [1]

Basel Place in Basel-Stadt, Switzerland

Basel is a city in northwestern Switzerland on the river Rhine. Basel is Switzerland's third-most-populous city with about 180,000 inhabitants.

In 1935, Geigy began research on moth- and plant-protection agents and Müller was specifically interested in plant protection. He said that his love for plants and nature in general, which led him to choose botany as a minor subject at university, brought him to think about plant protection. Specifically, he wanted to start synthesizing chemical plant protection agents himself. [1] In 1937, he patented a technique for synthesizing novel rhodanide- and cyanate-based compounds which showed bactericide and insecticide activity. [1] He then developed the product Graminone, a seed disinfectant which was safer than the mercury-based disinfectants at the time. [2] [3]

Synthesis of DDT

After his success with tanning agents and disinfectants, Müller was assigned to develop an insecticide. "At that time," according to The World of Anatomy and Physiology, "the only available insecticides were either expensive natural products or synthetics ineffective against insects; the only compounds that were both effective and inexpensive were arsenic compounds, which were just as poisonous to human beings and other mammals." [2]

During the course of his research, Müller found that insects absorbed chemicals differently than mammals. This led him to believe it likely that there are chemicals toxic exclusively to insects. He sought to "synthesize the ideal contact insecticide—one which would have a quick and powerful toxic effect upon the largest possible number of insect species while causing little or no harm to plants and warm-blooded animals." He also made it his goal to create an insecticide that was long-lasting and cheap to produce, along with a high degree of chemical stability. [2]

In embracing this goal, Müller was motivated by two events. The first of these was a major food shortage in Switzerland, which underscored the need for a better way to control the infestation of crops by insects. The second was the typhus epidemic in Russia, which was the most extensive and lethal such epidemic in history. [2] He began his search for his insecticide in 1935.

He studied all the data he could find on the subject of insecticides, decided which chemical properties the kind of insecticide he was in search of would exhibit, and set out to find a compound that would suit his purposes. Müller spent four years searching and failed 349 times before, in September 1939, he found the compound he was looking for. He placed a fly in a cage laced with one particular compound, and short while later, the fly died. [2]

The compound he had placed in the cage was dichlorodiphenyltrichloroethane (DDT), or, more precisely, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane, which a Viennese pharmacologist named Othmar Zeidler had first synthesized in 1874. Zeidler, while publishing a paper about his synthesis, had not investigated the properties of the new compound, and had thus failed to recognize its extraordinary value as an insecticide.

Müller quickly realized that DDT was the chemical he had been searching for. Tests of DDT by the Swiss government and the U.S. Department of Agriculture confirmed its effectiveness against the Colorado potato beetle. Further tests demonstrated its astonishing effectiveness against a wide range of pests, including the mosquito, louse, flea, and sandfly, which, respectively, spread malaria, typhus, the plague, and various tropical diseases.

Application of DDT

After taking out a Swiss patent on DDT in 1940 (a U.K. patent followed in 1942 and patents in the U.S. and Australia in 1943), Geigy began to market two DDT-based products, a 5% dust called Gesarol spray insecticide and a 3% dust called Neocid dust insecticide. The name DDT was first employed by the British Ministry of Supply in 1943, and the product was added to U.S. Army supply lists in May of the same year. It was also in 1943 that the first practical tests of DDT as a residual insecticide against adult vector mosquitoes were carried out. The next year, in Italy, tests were performed in which residual DDT was applied to the interior surfaces of all habitations and outbuildings of a community to test its effect on Anopheles vectors and malaria incidence.

DDT saved the lives of millions during World War II. [4] Between the 1950s and 1970s, DDT helped eradicate malaria entirely from many countries, the U.S. included. [4]

Later scientific career

Müller became Geigy's Deputy Director of Scientific Research on Substances for Plant Protection in 1946. In 1948 he was awarded the Nobel Prize in Physiology and Medicine, "for his discovery of the high efficiency of DDT as a contact poison against several arthropods." [3] The fact that he was accorded this honour even though he was neither a physician nor a medical researcher reflected the immense impact that DDT had had in the fight against human disease. The Nobel Committee said: "DDT has been used in large quantities in the evacuation of concentration camps, of prisons and deportees. Without any doubt, the material has already preserved the life and health of hundreds of thousands." In 1951, Müller was one of seven Nobel Laureates who attended the 1st Lindau Nobel Laureate Meeting. [5]

In addition to the 1948 Nobel Prize in physiology or medicine, Müller received an honorary doctorate from the University of Thessalonica in Greece in recognition of DDT's impact on the Mediterranean region. He retired from Geigy in 1961, continuing his research in a home laboratory. [3]

Personal life

In high school, Paul was only an average student. His grades suffered because he spent all his free time in his little home laboratory performing elementary experiments. In high school and college, Paul was often mocked by his peers being called, "The Ghost," due to his thin and pale appearance. [6]

Müller married Friedel Rüegsegger in 1927 and had two sons, Heinrich (b. 1929) and Niklaus (b. 1933), and one daughter, Margaretha (b. 1934). [7] His wife took charge of the household and raised their two sons and daughter so that Paul could concentrate on chemistry. [6]

In his free time, Müller enjoyed the nature in the Swiss Alps and in the Swiss Jura where he owned a small holiday home, allowing Paul to resume his longtime interest in botany. Furthermore, he owned a small fruit farm that he regularly tended to. Müller often relaxed while gardening, photographing mountain wildflowers, and taking the children on early morning nature walks. Moreover, Paul and his wife, Friedel, often enjoyed playing flute and piano duets from Gluck’s Orfeo and Eurydice. [6]

Reading on the weekends in the mountains, Müller immersed himself in the science of plant protection and pest control. This fascination resulted in his research on pesticides at Geigy, and sequentially the discovery of DDT's pesticidal properties. [6]

Müller was regarded as an independent soul; a lone wolf. In fact, his daughter, Margaretha, called him an Eigenbrötler— one "who makes his own bread." He was determined and persistent in all aspects of his life, having learned a great deal from his college mentor, Professor Fichter. [6]

He died in the early morning of October 13, 1965 in Basel after a short illness surrounded by family and loved ones. [8]

Honors

Müller received many honors in his life, among them the Nobel Prize in Physiology or Medicine. Specifically Greece honored him for the near elimination of malaria in the country as a result of his discovery. In 1963, he was invited to Greece and received with great sympathy and celebrated as national hero. [1]

Publications

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References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 Augustin, Frank (1993). Zur Geschichte des Insektizids Dichlordiphenyltrichloräthan (DDT) unter besonderer Berücksichtigung der Leistung des Chemikers Paul Müller (1899 - 1965). Leipzig: Medizinische Fakultät der Universität Leipzig. pp. 1–77.
  2. 1 2 3 4 5 6 7 "Paul Hermann Müller Biography". Gale Group (World of Anatomy and Physiology).
  3. 1 2 3 4 "The Nobel Prize in Physiology or Medicine 1948: Paul Müller". Nobelprize.org.
  4. 1 2 "The Truth About DDT and Silent Spring". The New Atlantis.
  5. "1st Lindau Nobel Laureate Meeting - Laureates". www.mediatheque.lindau-nobel.org. Retrieved 2018-01-09.
  6. 1 2 3 4 5 McGrayne, S. B. Prometheans in the lab: chemistry and the making of the modern world; McGraw-Hill: New York, 2002; p 148-162
  7. Paul Hermann Müller, Nobel Prize in Physiology or Medicine, 1948. https://www.geni.com/people/Paul-Müller-Nobel-Prize-in-Physiology-or-Medicine-1948/6000000029325653148 (accessed Nov 12, 2018).
  8. 1 2 3 4 5 "Dr. Paul Müller" (PDF). Nature. 208 (5015): 1043–4. December 1965. doi:10.1038/2081043b0. ISSN   0028-0836. PMID   5331547 . Retrieved 2012-11-24.