SF3B14

Last updated
SF3B6
Protein SF3B14 PDB 2f9d.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SF3B6 , HSPC175, Ht006, P14, SAP14, SAP14a, SF3B14, SF3B14a, CGI-110, splicing factor 3b subunit 6
External IDs OMIM: 607835 MGI: 1913305 HomoloGene: 9360 GeneCards: SF3B6
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016047

NM_025323

RefSeq (protein)

NP_057131

NP_079599

Location (UCSC) Chr 2: 24.07 – 24.08 Mb Chr 12: 4.87 – 4.88 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Splicing factor 3B, 14 kDa subunit, also known as SF3B14, is a human gene. [5]

Contents

Function

This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [5]

Interactions

SF3B14 has been shown to interact with SF3B1. [6] [7]

Related Research Articles

<span class="mw-page-title-main">Spliceosome</span> Molecular machine that removes intron RNA from the primary transcript

A spliceosome is a large ribonucleoprotein (RNP) complex found primarily within the nucleus of eukaryotic cells. The spliceosome is assembled from small nuclear RNAs (snRNA) and numerous proteins. Small nuclear RNA (snRNA) molecules bind to specific proteins to form a small nuclear ribonucleoprotein complex, which in turn combines with other snRNPs to form a large ribonucleoprotein complex called a spliceosome. The spliceosome removes introns from a transcribed pre-mRNA, a type of primary transcript. This process is generally referred to as splicing. An analogy is a film editor, who selectively cuts out irrelevant or incorrect material from the initial film and sends the cleaned-up version to the director for the final cut.

<span class="mw-page-title-main">U4 spliceosomal RNA</span> Non-coding RNA component of the spliceosome

The U4 small nuclear Ribo-Nucleic Acid is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6, and with each splicing round, it is displaced from the U6 snRNA in an ATP-dependent manner, allowing U6 to re-fold and create the active site for splicing catalysis. A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved.

snRNP70 Protein-coding gene in the species Homo sapiens

snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

<span class="mw-page-title-main">SFPQ</span> Non-coding RNA in the species Homo sapiens

Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene.

<span class="mw-page-title-main">U2 small nuclear RNA auxiliary factor 1</span> Protein-coding gene in the species Homo sapiens

Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.

<span class="mw-page-title-main">Small nuclear ribonucleoprotein D2</span> Protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

<span class="mw-page-title-main">SF3A1</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.

<span class="mw-page-title-main">PRPF3</span> Protein-coding gene in the species Homo sapiens

U4/U6 small nuclear ribonucleoprotein Prp3 is a protein that in humans is encoded by the PRPF3 gene.

<span class="mw-page-title-main">SF3B1</span> Protein-coding gene in humans

Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene.

<span class="mw-page-title-main">SF3A3</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.

<span class="mw-page-title-main">Small nuclear ribonucleoprotein polypeptide F</span> Protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.

<span class="mw-page-title-main">SF3A2</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3A subunit 2 is a protein that in humans is encoded by the SF3A2 gene.

<span class="mw-page-title-main">SF3B2</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.

<span class="mw-page-title-main">SF3B4</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3B subunit 4 is a protein that in humans is encoded by the SF3B4 gene.

<span class="mw-page-title-main">SF3B3</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.

<span class="mw-page-title-main">EFTUD2</span> Protein-coding gene in the species Homo sapiens

116 kDa U5 small nuclear ribonucleoprotein component is a protein that in humans is encoded by the EFTUD2 gene.

<span class="mw-page-title-main">LSM6</span> Protein-coding gene in the species Homo sapiens

U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.

<span class="mw-page-title-main">DDX46</span> Protein-coding gene in the species Homo sapiens

Probable ATP-dependent RNA helicase DDX46 is an enzyme that in humans is encoded by the DDX46 gene.

<span class="mw-page-title-main">DDX42</span> Protein-coding gene in the species Homo sapiens

ATP-dependent RNA helicase DDX42 is an enzyme that in humans is encoded by the DDX42 gene.

<span class="mw-page-title-main">SF3B5</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3B subunit 5 is a protein that in humans is encoded by the SF3B5 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115128 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037361 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: SF3B14 splicing factor 3B, 14 kDa subunit".
  6. Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Lührmann R, Query CC (August 2001). "A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site". EMBO J. 20 (16): 4536–46. doi:10.1093/emboj/20.16.4536. PMC   125580 . PMID   11500380.
  7. Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (September 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC   126279 . PMID   12234937.

Further reading