SF3B6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | SF3B6 , HSPC175, Ht006, P14, SAP14, SAP14a, SF3B14, SF3B14a, CGI-110, splicing factor 3b subunit 6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 607835 MGI: 1913305 HomoloGene: 9360 GeneCards: SF3B6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Splicing factor 3B, 14 kDa subunit, also known as SF3B14, is a human gene. [5]
This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [5]
A spliceosome is a large ribonucleoprotein (RNP) complex found primarily within the nucleus of eukaryotic cells. The spliceosome is assembled from small nuclear RNAs (snRNA) and numerous proteins. Small nuclear RNA (snRNA) molecules bind to specific proteins to form a small nuclear ribonucleoprotein complex, which in turn combines with other snRNPs to form a large ribonucleoprotein complex called a spliceosome. The spliceosome removes introns from a transcribed pre-mRNA, a type of primary transcript. This process is generally referred to as splicing. An analogy is a film editor, who selectively cuts out irrelevant or incorrect material from the initial film and sends the cleaned-up version to the director for the final cut.
The U4 small nuclear Ribo-Nucleic Acid is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6, and with each splicing round, it is displaced from the U6 snRNA in an ATP-dependent manner, allowing U6 to re-fold and create the active site for splicing catalysis. A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved.
snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein that in humans is encoded by the SNRNP70 gene. snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease. U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.
Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene.
Splicing factor U2AF 35 kDa subunit is a protein that in humans is encoded by the U2AF1 gene.
Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene. It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.
Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.
U4/U6 small nuclear ribonucleoprotein Prp3 is a protein that in humans is encoded by the PRPF3 gene.
Splicing factor 3B subunit 1 is a protein that in humans is encoded by the SF3B1 gene.
Splicing factor 3A subunit 3 is a protein that in humans is encoded by the SF3A3 gene.
Small nuclear ribonucleoprotein F is a protein that in humans is encoded by the SNRPF gene.
Splicing factor 3A subunit 2 is a protein that in humans is encoded by the SF3A2 gene.
Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.
Splicing factor 3B subunit 4 is a protein that in humans is encoded by the SF3B4 gene.
Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.
116 kDa U5 small nuclear ribonucleoprotein component is a protein that in humans is encoded by the EFTUD2 gene.
U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.
Probable ATP-dependent RNA helicase DDX46 is an enzyme that in humans is encoded by the DDX46 gene.
ATP-dependent RNA helicase DDX42 is an enzyme that in humans is encoded by the DDX42 gene.
Splicing factor 3B subunit 5 is a protein that in humans is encoded by the SF3B5 gene.