Stanford Moore

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Stanford Moore
Stanford Moore.jpg
Born September 4, 1913
DiedAugust 23, 1982 (1982-08-24) (aged 68)
New York City
Nationality U.S.
Alma mater Vanderbilt University
University of Wisconsin–Madison
Known for ribonuclease
Awards Nobel Prize in Chemistry in 1972
Scientific career
Fields biochemistry
Institutions Rockefeller University

Stanford Moore (September 4, 1913 August 23, 1982) was an American biochemist. He shared a Nobel Prize in Chemistry in 1972 (with Christian B. Anfinsen and William Howard Stein, for work done at Rockefeller University on the structure of the enzyme ribonuclease and for contributing to the understanding of the connection between the chemical structure and catalytic activity of the ribonuclease molecule.

Biochemist Scientist specialized in biochemistry

Biochemists are scientists that are trained in biochemistry.

Nobel Prize in Chemistry One of the five Nobel Prizes established in 1895 by Alfred Nobel

The Nobel Prize in Chemistry is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the will of Alfred Nobel in 1895, awarded for outstanding contributions in chemistry, physics, literature, peace, and physiology or medicine. This award is administered by the Nobel Foundation, and awarded by Royal Swedish Academy of Sciences on proposal of the Nobel Committee for Chemistry which consists of five members elected by Academy. The award is presented in Stockholm at an annual ceremony on December 10, the anniversary of Nobel's death.

Christian B. Anfinsen American biochemist

Christian Boehmer Anfinsen Jr. was an American biochemist. He shared the 1972 Nobel Prize in Chemistry with Stanford Moore and William Howard Stein for work on ribonuclease, especially concerning the connection between the amino acid sequence and the biologically active conformation.

Moore attended Peabody Demonstration School, now known as University School of Nashville, and in 1935 graduated summa cum laude from Vanderbilt University, where he was a member of Phi Kappa Sigma. He earned his doctorate in Organic Chemistry from the University of Wisconsin–Madison in 1938. Moore then joined the staff of the Rockefeller Institute, later Rockefeller University, where he spent his entire professional career, with the exception of a period of government service during World War II. He became Professor of Biochemistry in 1952.

Vanderbilt University Private research university in Nashville, Tennessee, United States

Vanderbilt University is a private research university in Nashville, Tennessee. Founded in 1873, it was named in honor of New York shipping and rail magnate Cornelius Vanderbilt, who provided the school its initial $1 million endowment despite having never been to the South. Vanderbilt hoped that his gift and the greater work of the university would help to heal the sectional wounds inflicted by the Civil War.

Phi Kappa Sigma North American collegiate fraternity

Phi Kappa Sigma (ΦΚΣ) is an international all-male college secret and social fraternity. While nicknames differ from institution to institution, the most common nicknames for the fraternity are Skulls, Skullhouse, Phi Kap, and PKS. Phi Kappa Sigma was founded by Dr. Samuel Brown Wylie Mitchell at the University of Pennsylvania. Mitchell recorded the initial ideas and concepts of Phi Kappa Sigma on August 16, 1850. He then began to discuss the idea with other students, first Charles Hare Hutchinson, and then Alfred Victor du Pont, John Thorne Stone, Andrew Adams Ripka, James Bayard Hodge, and Duane Williams. The seven men formally founded the fraternity on October 19, 1850 becoming the founding fathers of Phi Kappa Sigma Phi Kappa Sigma is a charter member of the North-American Interfraternity Conference, and since 2017, is headquartered in Carmel, Indiana. Prior to that, starting with its founding in 1850, the fraternity was based out of Philadelphia, Valley Forge and Chester Springs, Pennsylvania.

University of Wisconsin–Madison Public university in Wisconsin, USA

The University of Wisconsin–Madison is a public research university in Madison, Wisconsin. Founded when Wisconsin achieved statehood in 1848, UW–Madison is the official state university of Wisconsin, and the flagship campus of the University of Wisconsin System. It was the first public university established in Wisconsin and remains the oldest and largest public university in the state. It became a land-grant institution in 1866. The 933-acre (378 ha) main campus, located on the shores of Lake Mendota, includes four National Historic Landmarks. The University also owns and operates a historic 1,200-acre (486 ha) arboretum established in 1932, located 4 miles (6.4 km) south of the main campus.

In 1958 he and William H. Stein developed the first automated amino acid analyzer, which facilitated the determination of protein sequences. In 1959 Moore and Stein announced the first determination of the complete amino acid sequence of an enzyme, ribonuclease, work which was cited in the Nobel award. He never married.

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Bovine pancreatic ribonuclease, also often referred to as bovine pancreatic ribonuclease A or simply RNase A, is a pancreatic ribonuclease enzyme that cleaves single-stranded RNA. Bovine pancreatic ribonuclease is one of the classic model systems of protein science. Two Nobel Prizes in Chemistry have been awarded in recognition of work on bovine pancreatic ribonuclease: in 1972, the Prize was awarded to Christian Anfinsen for his work on protein folding and to Stanford Moore and William Stein for their work on the relationship between the protein's structure and its chemical mechanism; in 1984, the Prize was awarded to Robert Bruce Merrifield for development of chemical synthesis of proteins.

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Digital object identifier Character string used as a permanent identifier for a digital object, in a format controlled by the International DOI Foundation

In computing, a Digital Object Identifier orDOI is a persistent identifier or handle used to uniquely identify objects, standardized by the International Organization for Standardization (ISO). An implementation of the Handle System, DOIs are in wide use mainly to identify academic, professional, and government information, such as journal articles, research reports and data sets, and official publications though they also have been used to identify other types of information resources, such as commercial videos.

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National Academy of Sciences science branch of the United States National Academies

The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the National Academy of Medicine (NAM).