Stephen Cusack | |
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 Stephen Cusack at the Royal Society admissions day in London, July 2015 | |
| Born | Stephen Anthony Cusack |
| Alma mater | Imperial College London (PhD) |
| Awards |
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| Scientific career | |
| Institutions | European Molecular Biology Laboratory |
| Thesis | Electron Density and Pair Correlation Functions in Metals (1976) |
| Website | embl |
Stephen Anthony Cusack FRS [1] is Head of the European Molecular Biology Laboratory (EMBL) site in Grenoble, France. [2] [3] [4] [5] [6] [7]
Cusack was educated at Imperial College London where he was awarded a PhD in 1976 for research on the Radial distribution function and electron density in metals. [8] [9] [10] [11]
Cusack was elected a Fellow of the Royal Society (FRS) in 2015. His certificate of election reads:
Stephen Cusack is internationally renowned for major contributions in three areas. He has elucidated the structure and function of protein-RNA complexes involved in RNA maturation, translation and pattern recognition. These are exemplified by work on amino acyl tRNA synthetases, crucial to protein synthesis in all living organisms and analyses of the innate immune recognition of pathogens. As head of the EMBL outstation in Grenoble he has played a pioneering role in the development of instrumentation for structural biology at the European Synchrotron Radiation Facility, benefiting the structural biology community throughout Europe, and he has recently played a wider role in Europe as a founder of the Instruct project. He has in addition made a series of seminal advances in our understanding of the structure and life cycle of viruses, with particular focus on therapeutic potential. [1]
In 1998, Cusack was elected as a member of the European Molecular Biology Organization. [12]
Sir John Cowdery Kendrew, was an English biochemist, crystallographer, and science administrator. Kendrew shared the 1962 Nobel Prize in Chemistry with Max Perutz, for their work at the Cavendish Laboratory to investigate the structure of heme-containing proteins.
An aminoacyl-tRNA synthetase, also called tRNA-ligase, is an enzyme that attaches the appropriate amino acid onto its corresponding tRNA. It does so by catalyzing the transesterification of a specific cognate amino acid or its precursor to one of all its compatible cognate tRNAs to form an aminoacyl-tRNA. In humans, the 20 different types of aa-tRNA are made by the 20 different aminoacyl-tRNA synthetases, one for each amino acid of the genetic code.
The European Molecular Biology Laboratory (EMBL) is a molecular biology research institution supported by 27 member states, two prospect states, and one associate member state. EMBL was created in 1974 and is an intergovernmental organisation funded by public research money from its member states. Research at EMBL is conducted by approximately 85 independent groups covering the spectrum of molecular biology. The list of independent groups at EMBL can be found at www
Sir Gregory Paul Winter is a Nobel Prize-winning British molecular biologist best known for his work on the therapeutic use of monoclonal antibodies. His research career has been based almost entirely at the MRC Laboratory of Molecular Biology and the MRC Centre for Protein Engineering, in Cambridge, England.
VenkatramanRamakrishnan is an Indian-born British-American structural biologist who shared the 2009 Nobel Prize in Chemistry with Thomas A. Steitz and Ada Yonath, "for studies of the structure and function of the ribosome".
Patrick Cramer is a German chemist, structural biologist, and molecular systems biologist. In 2020, he was honoured to be an international member of the National Academy of Sciences.
Michael Levitt, is a South African-born biophysicist and a professor of structural biology at Stanford University, a position he has held since 1987. Levitt received the 2013 Nobel Prize in Chemistry, together with Martin Karplus and Arieh Warshel, for "the development of multiscale models for complex chemical systems". In 2018, Levitt was a founding co-editor of the Annual Review of Biomedical Data Science.
The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical research laboratory with a much broader focus.
Dame Janet Maureen Thornton, is a senior scientist and director emeritus at the European Bioinformatics Institute (EBI), part of the European Molecular Biology Laboratory (EMBL). She is one of the world's leading researchers in structural bioinformatics, using computational methods to understand protein structure and function. She was formerly director of the EBI from October 2001 to June 2015, and played a key role in ELIXIR.
Tyrosine—tRNA ligase, also known as tyrosyl-tRNA synthetase is an enzyme that is encoded by the gene YARS. Tyrosine--tRNA ligase catalyzes the chemical reaction
SARS and cytoplasmic seryl-tRNA synthetase are a human gene and its encoded enzyme product, respectively. SARS belongs to the class II amino-acyl tRNA family and is found in all humans; its encoded enzyme, seryl-tRNA synthetase, is involved in protein translation and is related to several bacterial and yeast counterparts.
28S ribosomal RNA is the structural ribosomal RNA (rRNA) for the large subunit (LSU) of eukaryotic cytoplasmic ribosomes, and thus one of the basic components of all eukaryotic cells. It has a size of 25S in plants and 28S in mammals, hence the alias of 25S–28S rRNA.
Burkhard Rost is a scientist leading the Department for Computational Biology & Bioinformatics at the Faculty of Informatics of the Technical University of Munich (TUM). Rost chairs the Study Section Bioinformatics Munich involving the TUM and the Ludwig Maximilian University of Munich (LMU) in Munich. From 2007-2014 Rost was President of the International Society for Computational Biology (ISCB).
Christine Anne Orengo is a Professor of Bioinformatics at University College London (UCL) known for her work on protein structure, particularly the CATH database. Orengo serves as president of the International Society for Computational Biology (ISCB), the first woman to do so in the history of the society.
Brian Selby Hartley FRS was a British biochemist. He was Professor of Biochemistry at Imperial College London from 1974 to 1991.
Kiyoshi Nagai was a Japanese structural biologist at the MRC Laboratory of Molecular Biology Cambridge, UK. He was known for his work on the mechanism of RNA splicing and structures of the spliceosome.
Dino Moras, born on 23 November 1944, is a French biochemist, research director at the CNRS and co-director of the Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Illkirch-Graffenstaden until 2010.
Leonid A. Sazanov is a Professor at the Institute of Science and Technology Austria (IST). Sazanov research explores the structure and function of large membrane protein complexes from the domain of bioenergetics. These molecular machines interconvert redox energy and proton motive force across biological membranes using a variety of mechanisms.
Anne Ephrussi is a French developmental and molecular biologist. Her research is focussed on the study of post-transcriptional regulations such as mRNA localization and translation control in molecular biology as well as the establishment of polarity axes in cell and developmental biology Ephrussi Group - RNA localisation and localised translation in development - EMBL. She is Head of the Developmental Biology Unit and director of the EMBL International Centre for Advanced Training (EICAT) program at the European Molecular Biology Laboratory (EMBL).
Xiang-Lei Yang (杨湘磊) is a Chinese-born American molecular biologist. She is a professor at The Scripps Research Institute, located in La Jolla, California. Her work has contributed to the establishment of physiological importance of aminoacyl-tRNA synthetases beyond their classical role in supporting mRNA translation and their disordered processes that contribute to disease. She founded the Translation Machinery in Health and Disease Gordon Research Conference, an ongoing biannual international conference since 2015. She helped co-found aTyr Pharma, a Nasdaq-listed biotechnology company.
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