Cholera is an infection of the small intestine by some strains of the bacterium Vibrio cholerae. Symptoms may range from none, to mild, to severe. The classic symptom is large amounts of watery diarrhea lasting a few days. Vomiting and muscle cramps may also occur. Diarrhea can be so severe that it leads within hours to severe dehydration and electrolyte imbalance. This may result in sunken eyes, cold skin, decreased skin elasticity, and wrinkling of the hands and feet. Dehydration can cause the skin to turn bluish. Symptoms start two hours to five days after exposure.
William Farr CB was a British epidemiologist, regarded as one of the founders of medical statistics.
John Snow was an English physician and a leader in the development of anaesthesia and medical hygiene. He is considered one of the founders of modern epidemiology and early germ theory, in part because of his work in tracing the source of a cholera outbreak in London's Soho, which he identified as a particular public water pump. Snow's findings inspired fundamental changes in the water and waste systems of London, which led to similar changes in other cities, and a significant improvement in general public health around the world.
Sir Joseph Fayrer, 1st Baronet FRS FRSE FRCS FRCP KCSI LLD was a British physician who served as Surgeon General in India. He is noted for his writings on medicine, work on public health and his studies particularly on the treatment of snakebite, in India. He was also involved in official investigation on cholera, in which he did not accept the idea, proposed by Robert Koch, of germs as the cause of cholera.
Edward Headlam Greenhow FRS, FRCP was an English physician, epidemiologist, sanitarian, statistician, clinician and lecturer.
Thomas Michael Greenhow MD MRCS FRCS was an English surgeon and epidemiologist.
The second cholera pandemic (1826–1837), also known as the Asiatic cholera pandemic, was a cholera pandemic that reached from India across Western Asia to Europe, Great Britain, and the Americas, as well as east to China and Japan. Cholera caused more deaths, more quickly, than any other epidemic disease in the 19th century. The medical community now believes cholera to be exclusively a human disease, spread through many means of travel during the time, and transmitted through warm fecal-contaminated river waters and contaminated foods. During the second pandemic, the scientific community varied in its beliefs about the causes of cholera.
The third cholera pandemic (1846–1860) was the third major outbreak of cholera originating in India in the 19th century that reached far beyond its borders, which researchers at University of California, Los Angeles (UCLA) believe may have started as early as 1837 and lasted until 1863. In the Russian Empire, more than one million people died of cholera. In 1853–1854, the epidemic in London claimed over 10,000 lives, and there were 23,000 deaths for all of Great Britain. This pandemic was considered to have the highest fatalities of the 19th-century epidemics.
The Broad Street cholera outbreak was a severe outbreak of cholera that occurred in 1854 near Broad Street in Soho, London, England, and occurred during the 1846–1860 cholera pandemic happening worldwide. This outbreak, which killed 616 people, is best known for the physician John Snow's study of its causes and his hypothesis that germ-contaminated water was the source of cholera, rather than particles in the air. This discovery came to influence public health and the construction of improved sanitation facilities beginning in the mid-19th century. Later, the term "focus of infection" started to be used to describe sites, such as the Broad Street pump, in which conditions are favourable for transmission of an infection. Snow's endeavour to find the cause of the transmission of cholera caused him to unknowingly create a double-blind experiment.
William Budd was an English physician and epidemiologist known for recognizing that infectious diseases were contagious. He recognized that the "poisons" involved in infectious diseases multiplied in the intestines of the sick, were present in their leaks, and could then be transmitted to the healthy through their consumption of contaminated water.
A dot distribution map is a type of thematic map that uses a point symbol to visualize the geographic distribution of a large number of related phenomena. Dot maps are a type of unit visualizations that rely on a visual scatter to show spatial patterns, especially variances in density. The dots may represent the actual locations of individual phenomena, or be randomly placed in aggregation districts to represent a number of individuals. Although these two procedures, and their underlying models, are very different, the general effect is the same.
Cefn Golau is a disused cholera cemetery situated on a narrow mountain ridge in the county borough of Blaenau Gwent, and located between Rhymney and Tredegar in south-east Wales. A suburb of Tredegar and a nearby feeder reservoir have the same name. The graves date from 1832 to 1855 with many for August and September 1849.
Seven cholera pandemics have occurred in the past 200 years, with the first pandemic originating in India in 1817. The seventh cholera pandemic is officially a current pandemic and has been ongoing since 1961, according to a World Health Organization factsheet in March 2022. Additionally, there have been many documented major local cholera outbreaks, such as a 1991–1994 outbreak in South America and, more recently, the 2016–2021 Yemen cholera outbreak.
A cholera pit was a burial place used in a time of emergency when the disease was prevalent. Such mass graves were often unmarked and were placed in remote or specially selected locations. Public fears of contagion, lack of space within existing churchyards and restrictions placed on the movements of people from location to location also contributed to their establishment and use. Many of the victims were poor and lacked the funds for memorial stones, however memorials were sometimes added at a later date.
Sir George Johnson was an eminent English physician who became recognized as an authority on cholera and kidney diseases. Some of his theories are no longer accepted today.
Diseases and epidemics of the 19th century included long-standing epidemic threats such as smallpox, typhus, yellow fever, and scarlet fever. In addition, cholera emerged as an epidemic threat and spread worldwide in six pandemics in the nineteenth century.
Thomas Lovell Buzzard MD FRCP was a Victorian English doctor who worked at the National Hospital, Queen Square. He was a pioneering neurologist who founded an epilepsy society and wrote also on Parkinson's disease. One of the last doctors to be trained through the apprenticeship route, Buzzard witnessed the Crimean War and later was a role model for the famous painting The Doctor.
Sidney Coupland was an English physician, specializing in pathological anatomy.
Isaac Burney Yeo was an English physician and writer.
Dr Thomas Blackall M.A., M.D., FRCP was an English physician, son of another renowned physician John Blackall. Born in Devon, he attended Cambridge, before working as a physician in London, and then returning to Devon on the death of his father, where he used his inheritance to purchase the large Spitchwick estate.
