Thymolphthalein

Last updated
Thymolphthalein
Thymolphthalein.svg
Names
IUPAC name
3,3-bis(4-hydroxy-2-methyl-5-propan-2-ylphenyl)-2-benzofuran-1-one
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.004.300
EC Number
  • 204-729-7
PubChem CID
UNII
Properties
C28H30O4
Molar mass 430.544 g·mol−1
AppearanceWhite powder
Melting point 248 to 252 °C (478 to 486 °F; 521 to 525 K)(decomposes)
Hazards
R-phrases (outdated) 4, 10
S-phrases (outdated) S22 S24/25
NFPA 704 (fire diamond)
Flammability code 0: Will not burn. E.g. waterHealth code 1: Exposure would cause irritation but only minor residual injury. E.g. turpentineReactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogenSpecial hazards (white): no codeThymolphthalein
0
1
0
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
X mark.svgN  verify  (what is  Yes check.svgYX mark.svgN ?)
Infobox references

Thymolphthalein is a phthalein dye used as an acidbase (pH) indicator. Its transition range is around pH 9.3–10.5. Below this pH, it is colorless; above, it is blue. The molar extinction coefficient for the blue thymolphthalein dianion is 38,000 M−1 cm−1 at 595 nm. [1]

Thymolphthalein(pH indicator)
below pH 9.3above pH 10.5
9.310.5
Thymolphthalein(pH indicator)
below pH <0above pH 9.3
<09.3

Thymolphthalein is also known to have use as a laxative [2] and for disappearing ink. [3]

Preparation

Thymolphthalein can be synthesized from thymol and phthalic anhydride

ThymolphthaleinSynthesis.png

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References

  1. Hahn HH; Cheuk SF; Elfenbein S; Wood WB (April 1970). "Studies on the Pathogenesis of Fever: Xix. Localization of Pyrogen in Granulocytes". J. Exp. Med. 131 (4): 701–9. doi:10.1084/jem.131.4.701. PMC   2138774 . PMID   5430784.
  2. Hubacher, MH; Doernberg, S; Horner, A (1953). "Laxatives: chemical structure and potency of phthaleins and hydroxyanthraquinones". J Am Pharm Assoc Am Pharm Assoc. 42 (1): 23–30. doi:10.1002/jps.3030420108. PMID   13034620.
  3. Katz, David A. (1982). "Disappearing Ink" (PDF). www.chymist.com. Retrieved August 14, 2017.