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Clinical data
Trade names Sundralen, Symcorad, Symcor
ATC code
Pharmacokinetic data
Elimination half-life 2.3–5 hours [1]
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
Formula C8H10ClN3S
Molar mass 215.70 g·mol−1
3D model (JSmol)
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Tiamenidine (BAN, USAN, INN, also known as thiamenidine, Hoe 440) is an imidazoline compound that shares many of the pharmacological properties of clonidine. It acts as a centrally-acting α1 and α2 adrenergic receptor antagonist (with IC50 4.85 μM and 0.0091 μM, respectively). [2] In hypertensive volunteers, like clonidine, it significantly increased sinus node recovery time and lowered cardiac output. [3] It was marketed (as tiamenidine hydrochloride) by Sanofi-Aventis [4] under the brand name Sundralen [5] for the management of essential hypertension. [6]



Tiamenidine synthesis: Tiamenidine-synthesis.svg
Tiamenidine synthesis:

Reaction of thiourea 1 with methyl iodide gives the corresponding S-methyl analogue (2), followed by heating with ethylenediamine, completes the synthesis of tiamenidine (3).

See also

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  7. US 3758476,issued 1973