Matrix metalloproteinases (MMPs), also known as matrixins, are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.
Sundance Mountain Resort is a ski resort located 13 miles (21 km) northeast of Provo, Utah. It spans over 5,000 acres (2,000 ha) on the slopes of Mount Timpanogos in Utah's Wasatch Range. Alpine skiing began on the site in 1944. Actor Robert Redford acquired the area in 1968, and established a year-round resort which would later spawn the independent Sundance Film Festival and the non-profit Sundance Institute. Sundance is committed to the balance of art, nature and community.
Mercaptopurine (6-MP), sold under the brand name Purinethol among others, is a medication used for cancer and autoimmune diseases. Specifically it is used to treat acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis. For ALL it is generally used with methotrexate. It is taken by mouth.
Combat Mecha Xabungle is a mecha anime television series created by Sunrise and directed by Yoshiyuki Tomino. It was broadcast on the Nagoya TV and TV Asahi networks weekly from February 6, 1982, to January 29, 1983. Promotional toys were produced by Clover. There was also a compilation movie made called Xabungle Graffiti, which included new footage and a different ending to the series. The anime series is licensed by Maiden Japan. It is currently streaming on Hidive, and it was released on an SDBD set on December 18, 2018.
The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4.
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The MMP2 gene is located on chromosome 16 at position 12.2.
Matrix metalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene.
Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. MMP-3 has an estimated molecular weight of 54 kDa.
Tissue inhibitor of metalloproteinases 2 (TIMP2) is a gene and a corresponding protein. The gene is a member of the TIMP gene family. The protein is thought to be a metastasis suppressor.
Matrilysin also known as matrix metalloproteinase-7 (MMP-7), pump-1 protease (PUMP-1), or uterine metalloproteinase is an enzyme in humans that is encoded by the MMP7 gene.
TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms.
A disintegrin and metalloproteinase with thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene.
Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene.
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene.
Matrix metalloproteinase-25 is an enzyme that in humans is encoded by the MMP25 gene.
A matrix metalloproteinase inhibitor (MMPI) inhibits matrix metalloproteinases. As they inhibit cell migration they have antiangiogenic effects. They may be both endogenous and exogenous.
Metalloprotease inhibitors are cellular inhibitors of the Matrix metalloproteinases (MMPs). MMPs belong to a family of zinc-dependent neutral endopeptidases. These enzymes have the ability to break down connective tissue. The expression of MMPs is increased in various pathological conditions like inflammatory conditions, metabolic bone disease, to cancer invasion, metastasis and angiogenesis.
Examples of diseases are periodontitis, hepatitis, glomerulonephritis, atherosclerosis, emphysema, asthma, autoimmune disorders of skin and dermal photoaging, rheumatoid arthritis, osteoarthritis, multiple sclerosis, Alzheimer's disease, chronic ulcerations, uterine involution, corneal epithelial defects, bone resorption and tumor progression and metastasis. Due to the role of MMPs in pathological conditions, inhibitors of MMPs may have therapeutic potential. Several other proteins have similar inhibitory effects, however none as effective. They might have other biological activities which have yet been fully characterised.
Dunderberg Mountain is a 1,086 feet (331 m) mountain on the west bank of the Hudson River at the southern end of the Hudson Highlands. It lies just above Jones Point, New York, within Bear Mountain State Park and the town of Stony Point in Rockland County, New York.
Angiogenesis is the process of forming new blood vessels from existing blood vessels. It is a highly complex process involving extensive interplay between cells, soluble factors, and the extracellular matrix (ECM). Angiogenesis is critical during normal physiological development, but it also occurs in adults during inflammation, wound healing, ischemia, and in pathological conditions such as rheumatoid arthritis, hemangioma, and tumor growth. Proteolysis has been indicated as one of the first and most sustained activities involved in the formation of new blood vessels. Numerous proteases including matrix metalloproteases (MMPs), a disintegrin and metalloprotease domain (ADAM), a disintegrin and metalloprotease domain with throbospondin motifs (ADAMTS), and cysteine and serine proteases are involved in angiogenesis. This article focuses on the important and diverse roles that these proteases play in the regulation of angiogenesis.
NephroCheck is a test that tries to determine the risk of some who is seriously sick developing acute kidney injury. Whether or not the test improves outcomes, however, is unclear as of 2016.
