Tomas Hökfelt (born 29 June 1940) is a Swedish physician and former professor in histology at the Karolinska Institutet from 1979 until 2006, when he got his emeritate. He was linked to the Department of Neuroscience and is specialized in cell biology.
Tomas Hökfelt was born in Stockholm, Sweden in 1940. He enrolled in the Karolinska Institutet in 1960 and got his BA in Medicine in 1960. He then studied at the Karolinska Institutet under professor Nils-Åke Hillarp, studying monoamine neurons, getting his PhD in 1968 and his MD in 1971. He became an assistant professor in 1968, and from 1979 until 2006, Hökfelt worked as a professor at the Karolinska Institute. He was also a faculty member of the Department of Biotechnology at the Royal Institute of Technology in Stockholm.
Tomas Hökfelt's early research was on neurotransmitters and neuropeptides in the brain.In 1977 he discovered that non-neurotransmitter peptide molecules like somatostatin, can exist with neurotransmitters in same peripheral and central neurons.
Hökfelt together with Serguei Fetissov has also conducted research into anorexia nervosa, indicating that it may be a disease, caused by a particular group of antibodies.
Together with Anders Björklund, he has edited 21 volumes of the Handbook of Chemical Neuroanatomy between 1983 and 2005
The arcuate nucleus of the hypothalamus is an aggregation of neurons in the mediobasal hypothalamus, adjacent to the third ventricle and the median eminence. The arcuate nucleus includes several important and diverse populations of neurons that help mediate different neuroendocrine and physiological functions, including neuroendocrine neurons, centrally projecting neurons, and astrocytes. The populations of neurons found in the arcuate nucleus are based on the hormones they secrete or interact with and are responsible for hypothalamic function, such as regulating hormones released from the pituitary gland or secreting their own hormones. Neurons in this region are also responsible for integrating information and providing inputs to other nuclei in the hypothalamus or inputs to areas outside this region of the brain. These neurons, generated from the ventral part of the periventricular epithelium during embryonic development, locate dorsally in the hypothalamus, becoming part of the ventromedial hypothalamic region. The function of the arcuate nucleus relies on its diversity of neurons, but its central role is involved in homeostasis. The arcuate nucleus provides many physiological roles involved in feeding, metabolism, fertility, and cardiovascular regulation.
Paul Greengard was an American neuroscientist best known for his work on the molecular and cellular function of neurons. In 2000, Greengard, Arvid Carlsson and Eric Kandel were awarded the Nobel Prize for Physiology or Medicine for their discoveries concerning signal transduction in the nervous system. He was Vincent Astor Professor at Rockefeller University, and served on the Scientific Advisory Board of the Cure Alzheimer's Fund, as well as the Scientific Council of the Brain & Behavior Research Foundation. He was married to artist Ursula von Rydingsvard.
Melanin-concentrating hormone (MCH) is a cyclic 19-amino acid orexigenic hypothalamic peptide originally isolated from the pituitary gland of teleost fish, where it controls skin pigmentation. In mammals it is involved in the regulation of feeding behavior, mood, sleep-wake cycle and energy balance.
Neuromodulation is the physiological process by which a given neuron uses one or more chemicals to regulate diverse populations of neurons. Neuromodulators typically bind to metabotropic, G-protein coupled receptors to initiate a second messenger signaling cascade that induces a broad, long-lasting signal. This modulation can last for hundreds of milliseconds to several minutes. Some of the effects of neuromodulators include: alter intrinsic firing activity, increase or decrease voltage-dependent currents, alter synaptic efficacy, increase bursting activity and reconfiguration of synaptic connectivity.
The periventricular nucleus is a thin sheet of small neurons located in the wall of the third ventricle, a composite structure of the hypothalamus. It functions in analgesia.
The Artois-Baillet Latour Foundation is a Belgian non-profit organization which was founded on 1 March 1974.
Barry John Everitt FRS, FMedSci, ScD, was Master of Downing College, Cambridge and is Professor of Behavioural Neuroscience and Director of Research at the University of Cambridge. He is Provost of the Gates Cambridge Trust at Cambridge University.
The Grande Médaille of the French Academy of Sciences, established in 1997, is awarded annually to a researcher who has contributed decisively to the development of science. It is the most prestigious of the Academy's awards, and is awarded in a different field each year. Its creation results from the combination of the original French Academy of Sciences Lalande Prize of 1802 with the Benjamin Valz Foundation Prize in 1970 and then with another 122 foundation prizes in 1997.
Michael Sela is an Israeli immunologist of Polish Jewish origin. He is W. Garfield Weston Professor of Immunology at the Weizmann Institute of Science in Rehovot.
Sten Grillner is a Swedish neurophysiologist and distinguished professor at the Karolinska Institute's Nobel Institute for Neurophysiology in Stockholm where he is the director of the institute. He is considered one of the world’s foremost experts in the cellular bases of motor behaviour. His research is focused on understanding the cellular bases of motor behaviour; in particular, he has shown how neuronal circuits in the spine help control rhythmic movements, such as those needed for locomotion. He is current secretary general of International Brain Research Organization IBRO and President of the Federation of European Neuroscience Societies (FENS). For his work, in 2008 he was awarded the $1 million Kavli Prize for deciphering the basic mechanisms which govern the development and functioning of the networks of cells in the brain and spinal cord. This prize distinguish the recipient from the Nobel prizes in basic medical sciences.
Balázs Gulyás is a Hungarian neurobiologist.
Ole Petter Ottersen is a Norwegian physician and neuroscientist. He serves as the Rector of Karolinska Institute in Sweden, and took office in August 2017. Ottersen has been professor of medicine at the University of Oslo since 1992 and served as the university's directly elected Rector from 2009 to 2017.
Thomas Christian Südhof, ForMemRS, is a German-American biochemist known for his study of synaptic transmission. Currently, he is a professor in the School of Medicine in the Department of Molecular and Cellular Physiology, and by courtesy in Neurology, and in Psychiatry and Behavioral Sciences at Stanford University.
Richard H. Scheller is the Chief Science Officer & Head of Therapeutics at 23andMe and the former Executive Vice President of Research and Early Development at Genentech. He was a Professor at Stanford University from 1982 to 2001 before joining Genentech. He has been awarded the Alan T. Waterman Award in 1989, the W. Alden Spencer Award in 1993 and the NAS Award in Molecular Biology in 1997, won the 2010 Kavli Prize in Neuroscience with Thomas C. Südhof and James E. Rothman, and won the 2013 Albert Lasker Award for Basic Medical Research with Thomas Sudhof. He was also given the Life Sciences Distinguished Alumni Award from University of Wisconsin–Madison. He is a Fellow of the American Academy of Arts and Sciences and a Member of the National Academy of Sciences.
Nils-Åke Hillarp was a Swedish scientist and a prominent force in research on the brain's monoamines.
Gene therapy is being studied for some forms of epilepsy. It relies on viral or non-viral vectors to deliver DNA or RNA to target brain areas where seizures arise, in order to prevent the development of epilepsy or to reduce the frequency and/or severity of seizures. Gene therapy has delivered promising results in early stage clinical trials for other neurological disorders such as Parkinson's disease, raising the hope that it will become a treatment for intractable epilepsy.
Per-Olof Åstrand was a Swedish professor of physiology at the Royal Gymnastic Central Institute (GCI/GIH) in Stockholm 1970–1977, and 1977–1988 at the Karolinska Institute in Stockholm, Sweden, and a member of the Nobel Assembly at Karolinska Institutet (1977–1988). Åstrand is considered a "pioneer", "legend" and one of the "founding fathers" of modern exercise physiology.
Tamas Bartfai, Ph.D., is a Hungarian neuroscientist with in neurotransmission, neuropeptides, prostaglandins, fever, and drug discovery. As of 2015, he is a professor in The Scripps Research Institute, and an adjunct professor at Stockholm University, the University of Oxford, and the University of Pennsylvania. As an author, he is widely held in libraries worldwide.
Per Svenningsson is a neurologist specializing in the neuropharmacology of movement disorders such as Parkinson’s disease. He is a professor of neurology at the Department of Clinical Neuroscience at the Karolinska Institutet and in the Department of Neurology at Karolinska University Hospital in Stockholm, Sweden. He is the team leader of a research group that studies the underlying pathogenic process of PD. Svenningsson is also a member of many research councils and committee, including the European College of Neuropsychopharmacology (ECNP).
Joël Bockaert is a French biologist.