Tomislav Domazet-Lošo

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Tomislav Domazet-Lošo (Split, 1974) is a Croatian geneticist. His fields of interest are evolutionary genetics, evolutionary developmental biology, macroevolution and tumor evolution. He is employed at the Ruđer Bošković Institute as a research fellow. [1] [2] [3] [4]

Contents

Education

Tomislav Domazet-Lošo, son of Croatian Admiral Davor Domazet-Lešo, was born in Split in 1974. In 1997, he graduated biology at the Faculty of Science in Zagreb, and, in 2003, he received his Ph.D. degree in genetics at the University of Cologne Institute for Genetics.

Research

In 2007, he discovered a method of genomic philostratigraphy which states that every living organism in its genome carries a record of its evolutionary path. Hence, it is possible to read the evolutionary history of the species. In his lecture on September 17, 2007, in the Hall of the Matthias of Croatia, Domazet-Lošo presented the first ever philostratigraphic maps. Before this discovery, the only direct approach to the research of evolutionary history was to study and compare the fossil remains discovered at sites all over the world.[ dubious ] Since it is impossible to predict where certain fossils are to be found, evolutionary research is largely dependent on good fortune in the discovery of high quality paleontological finds. The theory of genomic philostratigraphy solved this problem. [5] [6] [7]

Domazet-Lošo and his associates have shown that parts of the body are exposed more to the environment have a higher chance to be affected by environmental evolutionary changes. Furthermore, they managed to show the sequence of so-called embryonic 'leaflets' that are produced in the newly conceived organism in the first days of development which is the cause of further development of all other tissues in further development.[ clarification needed ] Finally, they discovered a possible genetic cause of the so-called Cambrian explosion, an event that intrigued even Charles Darwin, when almost 540 million years ago in a geologically brief period, nearly all existing animal forms have suddenly disappeared. The method, on the other hand, cannot see relatively tiny events like the separation of man and chimpanzee. The widespread scientific work of Dr. Tomislav Domazet-Loš and his associates was premiered in Split at the 5th World Conference on Forensic Genetics and Molecular Anthropology.[ citation needed ]

Domazet's work is a powerful proof of the theory of evolution, although it is assumed that the evolutionary history of the species of 200 years[ clarification needed ] has been mirrored in animal embryonic development, but has not been scientifically confirmed so far. Novelty is in the discovery of statistics-based genomic phylostratigraphy, which is based on statistics and which can measure the overall evolutionary age of active genes during each stage of embryonic development. The genomic phylostratiphraphic method is excellent for the reconstruction of the distant evolutionary past, for example, fifty million or one billion years old, which could only be studied solely with the help of fossils. The loin method was experimentally demonstrated three years ago and the research was done on a zebra fish. With the help of genomic phylostratigraphy, it has been shown that approximately in the middle of embryonic development there is a period when all vertebrae are morphologically similar. At this stage, which is called filetypes, differences in the appearance of fish, reptiles, and mammals are almost insignificant. [8] [9]

Genome phylostratigraphy opens up new chapters in research of hard-to-resolve problems in biology and medicine, and it could be particularly important to understand the understanding of tumor genetics. Domazet-Lošo and his team, for the first time, have shown in research on hydrates that even simple organisms may have tumors, and it follows that the possibility of tumor development is actually an immanent feature of multiplicity. The usefulness of this information for medicine is huge, and the scale is unpredictable. [10] [11] [12] [13]

Related Research Articles

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A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Model organisms are widely used to research human disease when human experimentation would be unfeasible or unethical. This strategy is made possible by the common descent of all living organisms, and the conservation of metabolic and developmental pathways and genetic material over the course of evolution.

Zoology is the branch of biology that studies the animal kingdom, including the structure, embryology, evolution, classification, habits, and distribution of all animals, both living and extinct, and how they interact with their ecosystems. The term is derived from Ancient Greek ζῷον, zōion, i.e. "animal" and λόγος, logos, i.e. "knowledge, study".

Evolutionary developmental biology Field of research that compares the developmental processes of different organisms to infer the ancestral relationships

Evolutionary developmental biology is a field of biological research that compares the developmental processes of different organisms to infer the ancestral relationships between them and how developmental processes evolved.

History of biology History of the study of life from ancient to modern times

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Molecular genetics is a sub-field of biology that addresses how differences in the structures or expression of DNA molecules manifests as variation among organisms. Molecular genetics often applies an "investigative approach" to determine the structure and/or function of genes in an organism's genome using genetic screens. The field of study is based on the merging of several sub-fields in biology: classical Mendelian inheritance, cellular biology, molecular biology, biochemistry, and biotechnology. Researchers search for mutations in a gene or induce mutations in a gene to link a gene sequence to a specific phenotype. Molecular genetics is a powerful methodology for linking mutations to genetic conditions that may aid the search for treatments/cures for various genetics diseases.

Phylogenesis

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The Ruđer Bošković Institute is a research institute located in the Šalata neighborhood of Zagreb, Croatia, founded in 1950, which studies the sciences.

Davor Domazet-Lošo

Davor Domazet-Lošo is a Croatian military and politician, former admiral of the Yugoslav Navy and then Croatian Navy.

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References

  1. "Tomislav Domazet-Lošo / Ljudi / Institut Ruđer Bošković" . Retrieved 20 July 2017.
  2. "Genetičari zaključuju: Tomislav Domazet-Lošo nije dokazao evoluciju" . Retrieved 20 July 2017.
  3. "doc. dr. sc. Tomislav Domazet-Lošo - Hrvatsko katoličko sveučilište" . Retrieved 20 July 2017.
  4. "Tomislav Domazet-Lošo: Sukob između vjere i znanosti ne postoji - Večernji list" . Retrieved 20 July 2017.
  5. "Hrvatski znanstvenik Tomislav Domazet-Lošo: "Ovi rezultati će ući u sve udžbenike tumorske biologije"" . Retrieved 20 July 2017.
  6. "Domazet-Lošo Tomislav" (PDF). Retrieved 20 July 2017.
  7. "Tomislav Domazet-Lošo, dr. sc" . Retrieved 20 July 2017.
  8. "Hrvat koji je srušio teoriju staru 3 i pol milijarde godina! - Dnevnik.hr" . Retrieved 20 July 2017.
  9. "Domazet-Lošo mlađi potvrdio teoriju evolucije - tportal" . Retrieved 20 July 2017.
  10. "Tomislav Domazet-Lošo - Prirodoslovno - matematički fakultet" . Retrieved 20 July 2017.
  11. "JOŠ JEDAN USPJEH HRVATSKOG ZNANSTVENIKAVeliko otkriće: Tomislav Domazet-Lošo dokazao da se geni i spontano stvaraju" . Retrieved 20 July 2017.
  12. "Tomislav Domazet Lošo: Vjernik sam i znanstvenik. To nije sukob" . Retrieved 20 July 2017.
  13. "Dr. Tomislav Domazet Lošo: Otkrili smo pratumor! > Slobodna Dalmacija" . Retrieved 20 July 2017.