Trius Therapeutics

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Trius Therapeutics (Nasdaq :  TSRX) was a biopharma company based in San Diego, CA that focused on the development of antibiotics. [1]


Business profile

The lead compound from Trius, tedizolid phosphate (formerly torezolid phosphate, TR-701), successfully completed its first Phase 3 clinical trial (ESTABLISH 1) in acute skin and skin structure infections (ABSSSI). [2] It is a once daily, IV and oral, oxazolidinone being developed for the treatment of serious grampositive infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). [3] The Phase 3 trials are being conducted under a Special Protocol Agreement with the US Food and Drug Administration and are using the draft FDA guidance of cessations of lesion spread at 48–72 hours as the primary endpoint. [4] In the ESTABLISH 1 Study, 200 mg of Tedizolid given for a short course of therapy (six days) was shown to be safe, well tolerated and was as effective as the traditional length of therapy with linezolid (600 mg for ten days). [5] Additionally, Tedizolid was shown to have fewer treatment-related side effects than linezolid and significantly fewer GI side effects. [6]

Trius was planning the second Phase 2 trial and expects to report results around the end of Q1 2013 and planned to submit an NDA to the FDA for the drug in the second half of 2013. [7]

Tedizolid was approved by the US Food and Drug Administration on June 20, 2014.

The firm was acquired by Cubist Pharmaceuticals at the end of July 2013 in a deal worth $1.6 billion. This fee also included the purchase of Optimer Pharmaceuticals. [8]


In February 2007 Trius was formed (formerly Rx3) in conjunction with a Series A financing. [9] Trius completed an initial public offering in August 2010, raising $50 million. [10] Its stock was added to the NASDAQ Biotechnology Index in 2012. [11]

Partnerships and Government Contracts

In 2008 the company received a $28 million contract from the National Institute of Allergy and Infectious Diseases a component of the National Institutes of Health, to develop antibiotics against gram-negative infections. The work included a collaboration with the Lawrence Livermore National Laboratory to help identify antibiotics against gram-negative infections and bioterrorism. [12] Trius was awarded a contract by Lawrence Livermore National Laboratory in 2011 for $3 million. [13] In 2011 Bayer acquired the exclusive rights to Trius' antibiotic tedizolid in certain areas in Asia, Africa, the Middle East, and Latin America. [14] The deal was reported as being worth $94 million. [15]


Trius was founded by the last Chief Financial Officer John Schmid and Chief Scientific Officer John Finn. [16] Other executives included Chief Executive Officer Jeffrey Stein, Chief Medical Officer Philippe Prokocimer, Chief Commercial Officer Craig Thompson, [17] and Chief Development Officer Ken Bartizal. [18] The Chairman of the Board is David Kabakoff. [19] The company today has 83 full-time employees. [20]

Related Research Articles

Methicillin-resistant <i>Staphylococcus aureus</i> Bacterium responsible for difficult-to-treat infections in humans

Methicillin-resistant Staphylococcus aureus (MRSA) is a group of Gram-positive bacteria that are genetically distinct from other strains of Staphylococcus aureus. MRSA is responsible for several difficult-to-treat infections in humans. It caused more than 100,000 deaths attributable to antimicrobial resistance in 2019.

Linezolid Antibiotic medication

Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA). The main uses are infections of the skin and pneumonia although it may be used for a variety of other infections including drug-resistant tuberculosis. It is used either by injection into a vein or by mouth.

Cefalexin Beta-lactam antibiotic

Cefalexin, also spelled cephalexin, is an antibiotic that can treat a number of bacterial infections. It kills gram-positive and some gram-negative bacteria by disrupting the growth of the bacterial cell wall. Cefalexin is a beta-lactam antibiotic within the class of first-generation cephalosporins. It works similarly to other agents within this class, including intravenous cefazolin, but can be taken by mouth.

Glycopeptide antibiotic

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Tedizolid Oxazolidinone-class antibiotic

Tedizolid, is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid. It was developed by Cubist Pharmaceuticals, following acquisition of Trius Therapeutics, and is marketed for the treatment of acute bacterial skin and skin structure infections.

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Skin and skin structure infections (SSSIs), also referred to as skin and soft tissue infections (SSTIs), or acute bacterial skin and skin structure infections (ABSSSIs), are infections of skin and associated soft tissues. Historically, the pathogen involved has most frequently been a bacterial species—always, since redescription of SSSIs as ABSSSIs—and as such, these infections require treatment by antibiotics.

Taksta is a front-loaded oral dosing regimen of sodium fusidate under development in the U.S. as an antibiotic for gram-positive infections including drug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA).

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  1. "Trius Therapeutics - About". Retrieved 26 July 2012.
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  7. Darcé, Keith (31 October 2011). "Trius grows as lead antibiotic moves forward". San Diego Union-Tribune. Retrieved 5 September 2012.
  8. Vrinda Manocha and Zeba Siddiqui (30 July 2013). "Cubist to pay up to $1.6 billion for two antibiotics makers". Reuters.
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  10. Scholer, Kristen; Spears, Lee (3 August 2010). "Trius Therapeutics Initial Offer Raises $50 Million". Bloomberg.
  11. "Semi-Annual Changes to the NASDAQ Biotechnology Index". MarketWatch. Retrieved 27 July 2012.
  12. Timmermeyer, Luke (22 October 2008). "Trius Therapeutics Wins $28M Contract From NIH For Bioterror Antibiotics". Xconomy. Retrieved 5 September 2012.
  13. Archived from the original on April 20, 2012.{{cite news}}: Missing or empty |title= (help)
  14. Conover, Damien (3 September 2012). "Premium Articles 5 Big Pharma Opportunities in Emerging Markets". Morning Start. Retrieved 5 September 2012.
  15. Darcé, Keith (27 July 2012). "Trius signs $94 million licensing deal for lead antibiotic". San Diego Union-Tribune. Retrieved 5 September 2012.
  16. "Trius Therapeutics Inc". Bloomberg News. Retrieved 5 September 2012.
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  19. "Trius Therapeutics, Inc. Executives". Hoover's. Retrieved 5 September 2012.
  20. "Company Overview of Trius Therapeutics, Inc". Businessweek. Retrieved 5 September 2012.