Kentucky Route 61 is a 151.333-mile (243.547 km) long Kentucky State Highway extending north from the Tennessee state line in Cumberland County to Columbia in Adair County through to Greensburg in Green County. From there, the route traverses LaRue, Hardin and Bullitt counties to terminate in Jefferson County at the junction of U.S. Route 31E in downtown Louisville.
U.S. Route 25W (US 25W) is the western branch of US 25 from Newport, Tennessee, where US 25 splits into US 25E and US 25W, to North Corbin, Kentucky, where the two highways rejoin.
Kentucky Route 90 is a major east–west state highway in southern Kentucky. The route is 134.734 miles (216.833 km) long, and it traverses Barren, Metcalfe, Cumberland, Clinton, Wayne, Pulaski, McCreary and Whitley Counties in southern Kentucky. It runs from the KY 70 junction near Interstate 65 in Cave City to US 25W about 8 miles (13 km) from Interstate 75.
Kentucky Route 70 (KY 70) is a long east-east state highway that originates at a junction with U.S. Route 60 (US 60) in Smithland in Livingston County, just east of the Ohio River. The route continues through the counties of Crittenden, Caldwell, Hopkins, Muhlenberg, Butler, Edmonson, Barren, Barren, Metcalfe, Green, Taylor, Casey, Pulaski, Lincoln and back into Pulaski again to terminate at a junction with US 150 near Maretburg in Rockcastle.
Kentucky Route 185 is a north–south state highway traversing four counties in west-central Kentucky.
U.S. Route 231 in Kentucky runs 114 miles (183 km) from the Tennessee state line near Adolphus to the William H. Natcher Bridge on the Ohio River near Rockport, Indiana. It crosses the state mainly in the west-central region, traversing Allen, Warren, Butler, Ohio, and Daviess Counties.
U.S. Route 431 in Kentucky runs 86.93 miles (139.90 km) from the Tennessee state line south of Adairville to US 60 at Owensboro. It crosses the state in mainly west-central portions of the state, passing through or near towns such as Russellville, Lewisburg, Central City and Livermore. The route goes through Logan, Muhlenberg, McLean, and Daviess counties.
Kentucky Route 181 (KY 181) is a north–south state highway that traverses two counties in western Kentucky.
Kentucky Route 218 is a 31.113-mile-long (50.072 km) west-east state highway that traverses three counties in south-central Kentucky. It is locally known as LeGrande Highway from Horse Cave to near Shady Grove.
Veterans Outer Loop is a major bypass route in Glasgow, Kentucky. It is maintained by the Kentucky Transportation Cabinet (KYTC).
Kentucky Route 136 is a 32.342-mile-long (52.049 km) state highway in northwestern Kentucky. It has two disconnected sections, one that goes from the Ohio River near Sloughs Wildlife Management Area to the Green River near Rangers Landing via Henderson, and the other that runs from KY 56 in Beech Grove west of Sebree to U.S. Route 231 (US 231) north of Hartford via Calhoun and Livermore.
The original alignment of Kentucky Route 67 (KY 67) was a north–south primary state highway that traversed Edmonson and Warren counties in south central Kentucky. It was one of the original state routes of the state highway system maintained by the Kentucky Transportation Cabinet. It was established in 1929 and was officially decommissioned in 1969. At the time of its removal from the state route system, it was estimated to be 21.491 miles (34.586 km) long as determined by the KYTC's state route logs and county road logs.
Kentucky Route 1681 is a 21.448-mile (34.517 km) state highway in Kentucky that runs from Kentucky Route 1659 immediately north of Millville to U.S. Route 60, Kentucky Route 922, and Manchester Street on the northwestern side of downtown Lexington.
Kentucky Route 1973 is a 33.886-mile-long (54.534 km) north–south secondary state highway located in Fayette and Scott counties in east-central Kentucky. It traverses the eastern and northern suburbs of Lexington and southern Scott County.
Kentucky Route 2155 is an urban secondary north–south state highway located entirely in Owensboro in northwest Kentucky.
Kentucky Route 550 (KY 550) is a 43.212 miles (69.543 km) state highway in eastern Kentucky that runs from Kentucky Routes 15 and 80 in northwestern Hazard to Kentucky Route 80 and Judge Road in Eastern via Darfork, Dwarf, Fisty, Carrie, Hindman, Garner, Mousie, Lackey, Garrett, and Eastern.
Kentucky Route 627 is a 30.367-mile-long (48.871 km) north–south state highway in east-central Kentucky, United States. It traverses portions of northern Madison, Clark, and southern Bourbon counties.
Kentucky Route 2831 is a 3.056-mile (4.918 km) state highway in Owensboro, Daviess County, Kentucky. It runs from U.S. Routes 60 and 431 in southern Owensboro to West Fifth Street and Frederica Streets in downtown.
Kentucky Route 1590 is a secondary state highway located entirely in Clinton County in south-central Kentucky.
U.S. Route 41 Alternate, also signed U.S. Route 41A in Tennessee (US 41A), connects the town of Monteagle, Tennessee, with Hopkinsville, Kentucky, 10 miles (16 km) north of the Tennessee line. It serves the city of Clarksville, Tennessee, on its way to Nashville, where it briefly runs concurrently with US 41. It then separates again to serve Shelbyville, Winchester, and Tullahoma before rejoining the main route atop Monteagle Mountain. US 41A runs west of US 41 for its entire length, aside from one mile in downtown Nashville where they are concurrent. US 41A is also concurrent with U.S. Route 31A from Nashville to Triune, Tennessee, for a distance of approximately 25 miles (40 km).
US 421 at the Virginia state line near Pennington Gap, VA 
