Interstate 75 (I-75) is a major north–south Interstate Highway in the Great Lakes and Southeastern regions of the United States. As with most Interstates that end in 5, it is a major cross-country, north–south route, traveling from State Road 826 and SR 924 on the Hialeah–Miami Lakes border to Sault Ste. Marie, Michigan, at the Canadian border. It is the second-longest north–south Interstate Highway and the seventh-longest Interstate Highway overall.
U.S. Route 27 or U.S. Highway 27 (US 27) is a north–south United States Numbered Highway in the Southern and Midwestern U.S. The southern terminus is at US 1 in Miami, Florida. The northern terminus is at Interstate 69 (I-69) in Fort Wayne, Indiana. From Miami, it goes up the center of Florida, then west to Tallahassee, Florida, and north through such cities and towns as Columbus, Georgia; Rome, Georgia; Chattanooga, Tennessee; Lexington, Kentucky; Cincinnati, Ohio; Oxford, Ohio; Richmond, Indiana; and Fort Wayne, Indiana. It once extended north through Lansing, Michigan, to Cheboygan, Mackinaw City, and, for about three years, even as far as St. Ignace. US 27 was first signed in 1926, replacing what had been the eastern route of the Dixie Highway in many states.
U.S. Route 41, also U.S. Highway 41 (US 41), is a major north–south United States Numbered Highway that runs from Miami, Florida, to the Upper Peninsula of Michigan. Until 1949, the part in southern Florida, from Naples to Miami, was US 94. The highway's southern terminus is in the Brickell neighborhood of Downtown Miami at an intersection with Brickell Avenue (US 1), and its northern terminus is east of Copper Harbor, Michigan, at a modest cul-de-sac near Fort Wilkins Historic State Park at the tip of the Keweenaw Peninsula. US 41 closely parallels Interstate 75 (I-75) from Naples, Florida, all the way through Georgia to Chattanooga, Tennessee.
U.S. Route 19 or U.S. Highway 19 (US 19) is a north–south United States Numbered Highway in the Eastern United States. Despite encroaching Interstate Highways, the route has remained a long-haul road, connecting the Gulf of Mexico with Lake Erie.
U.S. Route 23 or U.S. Highway 23 (US 23) is a major north–south United States Numbered Highway between Jacksonville, Florida, and Mackinaw City, Michigan. It is an original 1926 route which originally reached only as far south as Portsmouth, Ohio, and has since been extended. It was formerly part of the major highway known as the Dixie Highway. The highway's southern terminus is in Jacksonville, Florida, at US 1/US 17. The northern terminus is at Interstate 75 (I-75) in Mackinaw City, Michigan.
U.S. Route 411 (US 411) is an alternate parallel-highway associated with US 11. It extends for about 309.7 miles (498.4 km) from US 78 in Leeds, Alabama, to US 25W/US 70 in Newport, Tennessee. US 411 travels through northeastern Alabama, northwestern Georgia, and southeastern Tennessee. It is signed north-south, as with most highways that have odd numbers, but the route runs primarily in a northeast-southwest direction, and covers a more east-west mileage than it does north-south. Notable towns and cities along its route include Gadsden, Alabama; Rome, Georgia; Cartersville, Georgia; Maryville, Tennessee; Sevierville, Tennessee, and Newport, Tennessee.
U.S. Route 319 is a spur of US 19. It runs for 303 miles (488 km) from US 98 at the foot of the John Gorrie Memorial Bridge across from downtown Apalachicola, Florida to US 1/SR 4 in Wadley, Georgia, through the Panhandle of Florida and the southern portion of Georgia.
U.S. Route 221 (US 221) is a 734-mile-long (1,181 km) spur of U.S. Route 21. It travels from Perry, Florida, at US 19/US 98/US 27 Alternate to Lynchburg, Virginia, at US 29 Business. It travels through the states of Florida, Georgia, South Carolina, North Carolina, and Virginia. It travels through the cities of Valdosta, Georgia; Spartanburg, South Carolina; Marion, North Carolina; Roanoke, Virginia; and Lynchburg, Virginia.
U.S. Route 129 (US 129) is an auxiliary route of US 29, which it intersects in Athens, Georgia. US 129 currently runs for 582 miles (937 km) from an intersection with US 19/US 27 ALT/US 98 in Chiefland, Florida, to an interchange with Interstate 40 (I-40) in Knoxville, Tennessee. It passes through the states of Florida, Georgia, North Carolina, and Tennessee. It goes through the cities of Macon, Athens, Gainesville, and Knoxville.
Interstate 75 (I-75) is a part of the Interstate Highway System that runs from the Hialeah–Miami Lakes border, a few miles northwest of Miami, to Sault Ste. Marie in the Upper Peninsula of Michigan. I-75 begins its national northward journey near Miami, running along the western parts of the Miami metropolitan area before traveling westward across Alligator Alley, resuming its northward direction in Naples, running along Florida's Gulf Coast, and passing the cities of Fort Myers, Punta Gorda, Venice, and Sarasota. The freeway passes through the Tampa Bay area before turning inward toward Ocala, Gainesville, and Lake City before leaving the state and entering Georgia. I-75 runs for 471 miles (758 km) in Florida, making it the longest Interstate in the state and also the longest in any state east of the Mississippi River. The Interstate's speed limit is 70 mph (110 km/h) for its entire length in Florida.
U.S. Highway 27 (US 27) in Florida is a north–south United States Numbered Highway. It runs 496.352 miles (798.801 km) from the Miami metropolitan area northwest to the Tallahassee metropolitan area. Throughout the state, US 27 has been designated the Claude Pepper Memorial Highway by the Florida Legislature. It was named after long-time Florida statesperson Claude Pepper, who served in both the U.S. Senate and House of Representatives. The stretch running from Miami to South Bay was originally designated the Thomas E. Will Memorial Highway by the Florida Legislature in 1937 when that portion was known as State Road 26 (SR 26). Thomas E. Will, the founder of Okeelanta, had worked for almost 20 years to get the state to build a road from Miami to the area south of Lake Okeechobee. For most of its length in the state, US 27 is a divided highway.
U.S. Highway 41 (US 41) in the state of Florida is a north–south United States Highway. It runs 479 miles (771 km) from Miami in South Florida northwest to the Georgia state line north of the Lake City area. Within the state, US 41 is paralleled by Interstate 75 (I-75) all the way from Miami to Georgia, and I-75 has largely supplanted US 41 as a major highway.
U.S. Route 301 in Florida runs from the Sarasota-Bradenton-Venice, Florida Metropolitan Statistical Area northeast to the Greater Jacksonville Metropolitan Area. The road is a spur of U.S. Route 1, which it intersects in Callahan.
U.S. Route 441 (US 441) in Florida is a north–south United States Highway. It runs 433 miles (697 km) from Miami in South Florida northwest to the Georgia state line, with the overall route continuing to Tennessee in the Rocky Top area.
State Route 9 (SR 9) is a west-to-east state highway in the U.S. state of Tennessee that is 131.33 miles (211.36 km) long. It begins in Campbell County and ends in Cocke County. SR 9 is little-known by the general public by this designation as it is overlain by U.S. Route 25W and U.S. Route 25 east of Newport; the "9" designation is seen on mileposts. The entire route is located in East Tennessee. Despite running concurrent with a North-South US Route, Route 9 is signed as east-west.
U.S. Highway 19 (US 19) is a 349-mile-long (562 km) United States Numbered Highway in the U.S. state of Georgia. It travels from the Florida state line south-southeast of Thomasville through Albany and Atlanta, to the North Carolina state line at a point north of Lake Nottely.
U.S. Route 41 (US 41) is a part of the United States Numbered Highway System that runs from Miami, Florida, to the Upper Peninsula of the US state of Michigan. In the U.S. state of Georgia it travels 387 miles (623 km) from the Florida state line southeast of Lake Park to the Tennessee state line south of East Ridge, Tennessee. Within the state, US 41 is paralleled by Interstate 75 (I-75) all the way from Florida to Tennessee, and I-75 has largely supplanted US 41 as a major highway. Due to this, the majority of the highway is not part of the National Highway System.
U.S. Route 441 (US 441) is a north–south United States Highway that runs from Miami, Florida to Rocky Top, Tennessee. In the U.S. state of North Carolina, US 441 travels for 64.5 miles (103.8 km) from the Georgia state line near Dillard, Georgia to the Tennessee state line in the Great Smoky Mountains National Park. US 441 is a primary route connecting the cities of Franklin, Sylva, and Cherokee in western North Carolina. The highway runs concurrently with other U.S. highways for much of its routing in North Carolina including US 23 from the Georgia state line to Dillsboro, US 64 in Franklin, US 74 from Dillsboro to near Qualla, and US 19 in Cherokee. US 441 has two business routes in North Carolina, in Franklin and Cherokee.
State Route 73 is west-north state highway in East Tennessee. For most of its length, it is an unsigned companion route to U.S. Route 321.
A total of at least twelve special routes of U.S. Route 441 have existed, and at least three have been deleted. These special routes include alternate routes, business loops, truck routes, and bypass routes which connect to U.S. Route 441 in the US states of Florida, Georgia, North Carolina, and Tennessee.
US 41 in Miami, FL 
US 25W / SR 116 in Rocky Top, TN 
