U.S. Route 42 is an east–west United States highway that runs southwest–northeast for 350 miles (560 km) from Louisville, Kentucky to Cleveland, Ohio. The route has several names including Pearl Road from Cleveland to Medina in Northeast Ohio, Reading Road in Cincinnati, Cincinnati and Lebanon Pike in southwestern Ohio and Brownsboro Road in Louisville. Traveling northeast, the highway ends in downtown Cleveland and traveling southwest ends in Louisville.
U.S. Route 431 (US 431) is a spur of U.S. Route 31. It currently travels for approximately 556 miles (895 km) from US 231/Alabama State Route 210 and US 231 Business and US 431 Bus. in Dothan, Alabama, to Owensboro, Kentucky, at US 60 and Kentucky Route 2831.
Interstate 265 (I-265) is a 41.8-mile (67.3 km) Interstate Highway partially encircling the Louisville metropolitan area. Starting from I-65 in the southern part of Louisville, it runs through Jefferson County, Kentucky, crosses the Ohio River on the Lewis and Clark Bridge into Indiana, meets I-65 for a second time, and then proceeds westbound to terminate at the I-64 interchange.
Interstate 275 (I-275) is an 83.71-mile-long (134.72 km) highway in Ohio, Indiana, and Kentucky that forms a complete beltway around the Cincinnati metropolitan area and includes a part in a state (Indiana) not entered by the parent route. It had been the only auxiliary Interstate that enters three states, but that changed in July 2018 when I-295 in Delaware and New Jersey was extended into Pennsylvania. It is the longest beltway with an Interstate highway designation in the United States, enclosing an area of over 250,000 acres (100,000 ha). It is also the third longest beltway overall in the United States—only the Sam Houston Tollway and the Grand Parkway encircling Greater Houston are longer. For a short distance in northwest Hamilton County, it overlaps with I-74 and US Route 52 (US 52).
State Route 235 is a 133.2-mile-long (214.4 km) north–south state highway in the western portion of the U.S. state of Ohio. Its southern terminus is at US 68 near the small town of Oldtown just north of Xenia, and its northern terminus is at State Route 65 at the Maumee River nearly 5 miles (8.0 km) east of Grand Rapids, west of Otsego.
Kentucky Route 55 is a 140.858-mile-long (226.689 km) state highway in the U.S. Commonwealth of Kentucky.
Kentucky Route 80 (KY 80) is a 483.55-mile-long (778.20 km) state highway in the southern part of the U.S. state of Kentucky. The route originates on the state's western border at Columbus in Hickman County, and stretches across the southern portion of the state, terminating southeast of Elkhorn City on the Virginia state line. It is the longest Kentucky State Highway, though the official distance as listed in route logs is much less due to multiple concurrencies with U.S. Route 68 (US 68) and U.S. Route 23.
State Route 4, formerly known as Inter-county Highway 4 until 1921 and State Highway 4 in 1922, is a major north–south state highway in Ohio. It is the fifth longest state route in Ohio. Its southern terminus is at U.S. Route 42 in Cincinnati, Ohio, and its northern terminus is at U.S. Route 6 in Sandusky, Ohio. Its path is nearly ruler-straight for many miles. Some portions of the route are still marked as Dixie Highway. The northern portion was constructed by the Columbus and Sandusky Turnpike Company, see Turnpike Lands.
U.S. Route 31W is the westernmost of two parallel routes for U.S. Route 31 from Nashville, Tennessee to Louisville, Kentucky. At one time, it split with U.S. Route 31E at Sellersburg, Indiana, crossing into nearby Louisville via the Kentucky & Indiana Terminal Bridge. Tennessee State Route 41 is its unsigned companion route in Tennessee.
State Route 253 (SR 253) is a very short east–west state highway in the southern part of the U.S. state of Ohio. With an overall length of just 0.56 miles (0.90 km), the majority of SR 253 is a part of the Jesse Stuart Memorial Bridge, which crosses over the Ohio River near Franklin Furnace, Ohio. The western terminus of SR 253 is at about the midspan of the bridge, where it crosses the Kentucky State Line and becomes Kentucky Route 10 (KY 10). The eastern terminus of the highway is at a diamond interchange with U.S. Route 52 (US 52) near the eastern landing of the Ohio River crossing. The current SR 253 was established in the late 1980s. However, an earlier version of the highway existed in the Medina vicinity from the early 1920s until the late 1950s.
State Route 852 is a north–south state highway in the southern portion of the U.S. state of Ohio. Its southern terminus is at the Kentucky state line on the Carl Perkins Memorial Bridge over the Ohio River near Portsmouth, and its northern terminus is at an interchange with the State Route 73/State Route 104 concurrency, just north of a complex interchange with U.S. Route 52 about 1.75 miles (2.82 km) west of Portsmouth.
The roads of Cincinnati, Ohio include three major interstate highways, one interstate bypass and one interstate spur and six U.S. highways.
State Route 41 is a north–south state highway in the southern and western portions of the U.S. state of Ohio. Its southern terminus is at U.S. Route 52, US 62 Business, and US 68 Business in Aberdeen. ; and its northern terminus is along SR 48 at US 36 in Covington. Throughout its southern portion the route is quite hilly as it passes predominantly northward through scenic areas with state parks and monuments. Along its northern portion the route heads in a more westerly direction across mainly flat terrain as a major road through the cities of Washington Court House, Springfield, and Troy.
State Route 369 (SR 369) is a short, two-lane north–south state highway in the western portion of the U.S. state of Ohio. The southern terminus of SR 369 is at an interchange with SR 4 approximately two and a half miles (4.0 km) northeast of Enon. Its northern terminus is at U.S. Route 40 (US 40) nearly one and a half miles (2.4 km) east of Donnelsville. SR 369 was created in the mid-1930s. In addition to serving as a connector between SR 4 and US 40 southwest of Springfield, it provides access to a county park named in honor of George Rogers Clark.
Interstate 75 (I-75) runs from Cincinnati to Toledo by way of Dayton in the US state of Ohio. The highway enters the state running concurrently with I-71 from Kentucky on the Brent Spence Bridge over the Ohio River and into the Bluegrass region. I-75 continues along the Mill Creek Expressway northward to the Butler County line just north of I-275. From there, the freeway runs into the Miami Valley and then passes through the Great Black Swamp before crossing into Michigan.
Interstate 70 (I-70) in the US state of Ohio provides access between Indiana and West Virginia. I-70 is a major highway for traffic within, to, from, and through Ohio. The highway is a core roadway of the Columbus metropolitan area and is of additional importance in the Dayton metropolitan area.
Eggner Ferry Bridge, also known as Eggner's Ferry Bridge, is a four-lane bridge in Trigg and Marshall counties in the U.S. state of Kentucky. The current through-arch bridge opened to traffic on April 7, 2016, replacing a two-lane bowstring truss bridge constructed in 1932. The bridge carries US 68 and Kentucky Route 80 across Kentucky Lake. The main span of the original 1932 bridge collapsed on January 26, 2012 after it was hit by a ship. There were no injuries. The bridge was repaired and reopened to traffic on May 25 of that year. On the morning of July 25, 2016, the middle four spans of the old Eggner's Ferry Bridge were brought down using controlled explosives.
U.S. Route 23 (US 23) is a United States Numbered Highway that runs from Jacksonville, Florida, to Mackinaw City, Michigan. In the state of Ohio, it is a major north–south state highway that runs from the Kentucky border at Portsmouth to the Michigan border at Sylvania.
U.S. Route 150 (US 150) in Kentucky is a 121.097-mile-long (194.887 km) east–west highway that runs from the Indiana state line above the Ohio River to US 25/KY 1249 at Mount Vernon.
US 62 at Reidland, KY 
I-75 / SR 15 in Findlay, OH 
