Ullrich Georg Trendelenburg

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Ullrich Georg Trendelenburg (31 December 1922 21 November 2006) was a German pharmacologist.


He was born in Gehlsdorf near Rostock. His paternal grandfather, Friedrich Trendelenburg (1844 to 1924) was the surgeon after whom Trendelenburg's sign for hip abductor weakness and the Trendelenburg test for varicose veins are named, whereas his father, Paul Trendelenburg (1884 to 1931), also was a pharmacologist. In the Institute of Pharmacology in Berlin led by his father, Ullrich got to know opponents of National Socialism such as Otto Krayer, Edith Bülbring and Marthe Vogt. In the Second World War, he volunteered for the Air force in order to escape the SS. After the war he studied medicine in Göttingen and Uppsala. From 1952 to 1956 he worked with Joshua Harold Burn (1892 to 1982) [1] in the Department of Pharmacology of the University of Oxford as a British Council Scholar and from 1957 to 1968 with Otto Krayer at the Department of Pharmacology of Harvard Medical School. From 1968 to 1991 he held the chair of pharmacology at the University of Würzburg. After his retirement he moved to Tübingen where he lived until his death and where he received lifelong friends such as the Portuguese pharmacologist Serafim Guimarães. [2] [3]

Rostock Place in Mecklenburg-Vorpommern, Germany

Rostock is a city in the north German state Mecklenburg-Vorpommern. Rostock is on the Warnow river; the district of Warnemünde, 12 kilometres north of the city centre, is directly on the Baltic Sea coast. Rostock is the largest city in Mecklenburg-Vorpommern, as well as its only regiopolis.

Friedrich Trendelenburg German surgeon

Friedrich Trendelenburg was a German surgeon. He was son of the philosopher Friedrich Adolf Trendelenburg, father of the pharmacologist Paul Trendelenburg and grandfather of the pharmacologist Ullrich Georg Trendelenburg.

Trendelenburgs sign

Trendelenburg's sign is found in people with weak or paralyzed abductor muscles of the hip, namely gluteus medius and gluteus minimus. It is named after the German surgeon Friedrich Trendelenburg.

Tubingen December 1995 Ullrich Trendelenburg.jpg
Tübingen December 1995

Trendelenburg’s main field of research was the pharmacology of the autonomic nervous system. He discovered new receptors at autonomic ganglion cells. He clarified mechanisms of hypersensitivity and subsensitivity to drugs, and his review of this subject became a citation classic. [4] [5] He also clarified the mode of action of direct-acting and indirect-acting sympathomimetic drugs. He identified pathways of inactivation of catecholamines in which a membrane transport protein and an enzyme are arranged in sequence. He termed such pathways "inactivating systems". [6] From 1975 to 1979 he was president of the German Pharmacological Society and from 1969 to 1991 editor — from 1977 to 1985 chief editor — of Naunyn-Schmiedeberg’s Archives of Pharmacology, the world's oldest still existing pharmacology journal. [7]

Autonomic nervous system division of the peripheral nervous system

The autonomic nervous system (ANS), formerly the vegetative nervous system, is a division of the peripheral nervous system that supplies smooth muscle and glands, and thus influences the function of internal organs. The autonomic nervous system is a control system that acts largely unconsciously and regulates bodily functions such as the heart rate, digestion, respiratory rate, pupillary response, urination, and sexual arousal. This system is the primary mechanism in control of the fight-or-flight response.

Ganglion nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system and sensory system; ganglia house the cells bodies of afferent nerves and efferent nerves

A ganglion is a nerve cell cluster or a group of nerve cell bodies located in the autonomic nervous system and sensory system. Ganglia house the cell bodies of afferent nerves and efferent nerves, or axons.

Sympathomimetic drug stimulant compounds

Sympathomimetic drugs are stimulant compounds which mimic the effects of endogenous agonists of the sympathetic nervous system. The primary endogenous agonists of the sympathetic nervous system are the catecholamines, which function as both neurotransmitters and hormones. Sympathomimetic drugs are used to treat cardiac arrest and low blood pressure, or even delay premature labor, among other things.

Inspired by his friendship with persons such as Otto Krayer, he published biographies of pharmacologists who had been persecuted by National Socialism [8]

Otto Hermann Krayer was a German-American physician, pharmacologist and university professor.

Trendelenburg was honorary member of the Polish, Indian, Czechoslovakian, German and Venezuelan Pharmacological Societies and honorary doctor of the medical faculties of five universities: Tampere, Finland, Porto, Portugal, Ohio State University, Lublin, Poland, and Prague. The German Pharmacologiocal Society awarded hin the Oswald Schmiedeberg medal, the highest scientific honor of the Society. [2]

A medical school is a tertiary educational institution, or part of such an institution, that teaches medicine, and awards a professional degree for physicians and surgeons. Such medical degrees include the Bachelor of Medicine, Bachelor of Surgery, Doctor of Medicine (MD), or Doctor of Osteopathic Medicine (DO). Many medical schools offer additional degrees, such as a Doctor of Philosophy (Ph.D), Master's degree (M.Sc), a physician assistant program, or other post-secondary education.

Tampere City in Pirkanmaa, Finland

Tampere is a city in Pirkanmaa, southern Finland. It is the most populous inland city in the Nordic countries.

Porto Municipality in Norte, Portugal

Porto is the second-largest city in Portugal after Lisbon and one of the major urban areas of the Iberian Peninsula. The city proper has a population of 287,591 and the metropolitan area of Porto, which extends beyond the administrative limits of the city, has a population of 2.3 million (2011) in an area of 2,395 km2 (925 sq mi), making it the second-largest urban area in Portugal. It is recognized as a gamma-level global city by the Globalization and World Cities (GaWC) Study Group, the only Portuguese city besides Lisbon to be recognised as a global city.

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  1. de:Joshua Harold Burn
  2. 1 2 Klaus Starke: In memoriam Ullrich Georg Trendelenburg (31 December 1922 to 21 November 2006). In: Naunyn-Schmiedeberg’s Archives of Pharmacology 2007; 375:231 - 240
  3. http://www.aspet.org/uploadedFiles/Publications/Journal_Search/v49n1_3_07.pdf
  4. Ullrich Trendelenburg: Supersensitivity and subsensitivity to sympathomimetic drugs. In: Pharmacological Reviews 1963;15:225 - 276
  5. http://garfield.library.upenn.edu/classics1984/A1984TD25400002.pdf
  6. Ullrich Trendelenburg: The metabolizing systems involved in the inactivation of catecholamines. In: Naunyn-Schmiedeberg’s Archives of Pharmacology 1986; 332:201 - 207
  7. de:Naunyn-Schmiedebergs Archiv
  8. Ullrich Trendelenburg: Verfolgte deutschsprachige Pharmakologen 1933 - 1945. Frechen, Dr. Schrör, 2006. ISBN   3-9806004-7-5