Willem Johan Kolff

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Willem Johan Kolff
Willem Johan Kolff.jpg
Born(1911-02-14)February 14, 1911
DiedFebruary 11, 2009(2009-02-11) (aged 97)
OccupationPhysician, Inventor
Awards Gairdner Foundation International Award (1966)
Harvey Prize (1972)
Wilhelm Exner Medal (1980) [1]
Japan Prize (1986)

Willem Johan "Pim" Kolff (February 14, 1911  February 11, 2009) was a pioneer of hemodialysis as well as in the field of artificial organs. Willem is a member of the Kolff family, an old Dutch patrician family. He made his major discoveries in the field of dialysis for kidney failure during the Second World War. He emigrated in 1950 to the United States, where he obtained US citizenship in 1955, and received a number of awards and widespread recognition for his work.

Hemodialysis

Hemodialysis, also spelled haemodialysis, or simply dialysis, is a process of purifying the blood of a person whose kidneys are not working normally. This type of dialysis achieves the extracorporeal removal of waste products such as creatinine and urea and free water from the blood when the kidneys are in a state of kidney failure. Hemodialysis is one of three renal replacement therapies. An alternative method for extracorporeal separation of blood components such as plasma or cells is apheresis.

An artificial organ is an engineered device or tissue that is implanted or integrated into a human — interfacing with living tissue — to replace a natural organ, to duplicate or augment a specific function or functions so the patient may return to a normal life as soon as possible. The replaced function does not have to be related to life support, but it often is. For example, replacement bones and joints, such as those found in hip replacements, could also be considered artificial organs.

Kolff family name

Kolff is the name of a Dutch patrician family originating from the provinces of Holland and Gelderland in the Netherlands.

Contents

Netherlands

Born in Leiden, Netherlands, Kolff was the eldest of a family of 5 boys. Kolff studied medicine in his hometown at Leiden University, and continued as a resident in internal medicine at Groningen University. One of his first patients was a 22-year-old man who was slowly dying of renal failure. This prompted Kolff to perform research on artificial renal function replacement. Also during his residency, Kolff organized the first blood bank in Europe (in 1940). Kolff's first prototype dialyzer was developed in 1943, built from orange juice cans, used auto parts, and sausage casings. [2] Over a two year span, Kolff had attempted to treat 15 people with his machine, but all had died. In 1945, Kolff successfully treated his first patient, a 67 year old woman, from renal failure using his hemodialysis machine.

Leiden City and municipality in South Holland, Netherlands

Leiden is a city and municipality in the province of South Holland, Netherlands. The municipality of Leiden had a population of 123,856 in August 2017, but the city forms one densely connected agglomeration with its suburbs Oegstgeest, Leiderdorp, Voorschoten and Zoeterwoude with 206,647 inhabitants. The Netherlands Central Bureau of Statistics (CBS) further includes Katwijk in the agglomeration which makes the total population of the Leiden urban agglomeration 270,879, and in the larger Leiden urban area also Teylingen, Noordwijk, and Noordwijkerhout are included with in total 348,868 inhabitants. Leiden is located on the Oude Rijn, at a distance of some 20 kilometres from The Hague to its south and some 40 km (25 mi) from Amsterdam to its north. The recreational area of the Kaag Lakes (Kagerplassen) lies just to the northeast of Leiden.

Netherlands Constituent country of the Kingdom of the Netherlands in Europe

The Netherlands is a country located mainly in Northwestern Europe. The European portion of the Netherlands consists of twelve separate provinces that border Germany to the east, Belgium to the south, and the North Sea to the northwest, with maritime borders in the North Sea with Belgium, Germany and the United Kingdom. Together with three island territories in the Caribbean Sea—Bonaire, Sint Eustatius and Saba— it forms a constituent country of the Kingdom of the Netherlands. The official language is Dutch, but a secondary official language in the province of Friesland is West Frisian.

Medicine The science and practice of the diagnosis, treatment, and prevention of physical and mental illnesses

Medicine is the science and practice of establishing the diagnosis, prognosis, treatment, and prevention of disease. Medicine encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness. Contemporary medicine applies biomedical sciences, biomedical research, genetics, and medical technology to diagnose, treat, and prevent injury and disease, typically through pharmaceuticals or surgery, but also through therapies as diverse as psychotherapy, external splints and traction, medical devices, biologics, and ionizing radiation, amongst others.

During World War II, he was in Kampen, where he was active in the resistance against the German occupation. Simultaneously, Kolff developed the first functioning artificial kidney. [3] He treated his first patient in 1943, and in 1945 he was able to save a patient's life with hemodialysis treatment. In 1946 he obtained a PhD degree summa cum laude at University of Groningen on the subject. It marks the start of a treatment that has saved the lives of millions of acute or chronic renal failure patients ever since.

World War II 1939–1945 global war

World War II, also known as the Second World War, was a global war that lasted from 1939 to 1945. The vast majority of the world's countries—including all the great powers—eventually formed two opposing military alliances: the Allies and the Axis. A state of total war emerged, directly involving more than 100 million people from over 30 countries. The major participants threw their entire economic, industrial, and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. World War II was the deadliest conflict in human history, marked by 50 to 85 million fatalities, most of whom were civilians in the Soviet Union and China. It included massacres, the genocide of the Holocaust, strategic bombing, premeditated death from starvation and disease, and the only use of nuclear weapons in war.

Dutch resistance

The Dutch resistance to the Nazi occupation of the Netherlands during World War II can be mainly characterized as non-violent, and was organized by the Communist Party, churches, and independent groups. A peak of over 300,000 people were hidden from German authorities in the autumn of 1944, tended to by some 60,000 to 200,000 illegal landlords and caretakers, and tolerated knowingly by some one million people, including a few incidental individuals among German occupiers and military.

University of Groningen university in the Netherlands

The University of Groningen is a public research university in the city of Groningen in the Netherlands. The university was founded in 1614. Since its founding more than 200,000 students have graduated.

United States

When the war ended, Kolff donated his artificial kidneys to other institutions to spread familiarity with the technology. In Europe, Kolff sent machines to London, Amsterdam, and Poland. Another machine sent to Dr. Isidore Snapper at Mount Sinai Hospital in New York City was used to perform the first human dialysis in the United States on January 26, 1948 under the supervision of Drs. Alfred P. Fishman and Irving Kroop. [4]

In 1950, Kolff left the Netherlands to seek opportunities in the US. At the Cleveland Clinic, he was involved in the development of heart-lung machines to maintain heart and pulmonary function during cardiac surgery. He also improved on his dialysis machine. At Brigham and Women's Hospital, with funding from New York real estate developer David Rose [5] he developed the first production artificial kidney, the Kolff Brigham Artificial Kidney, manufactured by the Edward A. Olson Co. in Boston Massachusetts, and later the Travenol Twin-Coil Artificial Kidney.

Cleveland Clinic Hospital in Ohio, United States

The Cleveland Clinic is an American academic medical center based in Cleveland, Ohio. Owned and operated by the Cleveland Clinic Foundation, an Ohio nonprofit corporation established in 1921, it runs a 170-acre campus in Cleveland, as well as 10 regional hospitals and 19 family health centers in north-east Ohio, and hospitals in Florida and Nevada. Tomislav Mihaljevic is the president and CEO.

Brigham and Womens Hospital Hospital in Massachusetts, United States

Brigham and Women's Hospital is located adjacent to Harvard Medical School, of which it is the second largest teaching affiliate. It is the largest hospital of the Longwood Medical and Academic Area in Boston, Massachusetts, US. With Massachusetts General Hospital, it is one of the two founding members of Partners HealthCare, the largest healthcare provider in Massachusetts. Brigham and Women's Hospital conducts the second largest hospital-based research program in the world, with an annual research budget of more than $630 million. Pioneering milestones include the world's first successful heart valve operation and the world's first solid organ transplant. Elizabeth Nabel is the current President of Brigham and Women's Hospital.

David Rose (1892–1986) was an American real estate developer and philanthropist who co-founded Rose Associates.

He became head of the University of Utah's Division of Artificial Organs and Institute for Biomedical Engineering in 1967, where he was involved in the development of the artificial heart, the first of which was implanted in 1982 in patient Barney Clark, who survived for four months, with the heart still functioning at the time of Clark's death. [3]

University of Utah School of Medicine

The University of Utah School of Medicine is located on the upper campus of the University of Utah in Salt Lake City, Utah. It was founded in 1905 and is currently the only MD-granting medical school in the state of Utah.

Artificial heart Medical device

An artificial heart is a device that replaces the heart. Artificial hearts are typically used to bridge the time to heart transplantation, or to permanently replace the heart in case heart transplantation is impossible. Although other similar inventions preceded it from the late 1940s, the first artificial heart to be successfully implanted in a human was the Jarvik-7 in 1982, designed by a team including Willem Johan Kolff and Robert Jarvik.

In 1976 Kolff became a corresponding member of the Royal Netherlands Academy of Arts and Sciences. [6]

Impact

Kolff is considered to be the Father of Artificial Organs, and is regarded as one of the most important physicians of the 20th century. [3] He obtained more than 12 honorary doctorates at universities all over the world, and more than 120 international awards, among them the Harvey Prize in 1972, AMA Scientific Achievement Award in 1982, the Japan Prize in 1986, the Albert Lasker Award for Clinical Medical Research in 2002, and the Russ Prize in 2003. In 1990 Life Magazine included him in its list of the 100 Most Important Persons of the 20th Century. He was a co-nominee with William H. Dobelle for the Nobel Prize in Physiology or Medicine in 2003. Robert Jarvik, who worked in Kolff's laboratory at the University of Utah beginning in 1971, credited Kolff with inspiring him to develop the first permanent artificial heart. [7]

Kolff died three days short of his 98th birthday on February 11, 2009, in a care center in Philadelphia. [3] On February 29, 2012, Yad Vashem recognized Willem Johan Kolff and his wife as Righteous Among the Nations, for their part in concealing a Jewish medical colleague and his son. [8]

Related Research Articles

Nephrology medical specialty

Nephrology is a specialty of medicine and pediatrics that concerns itself with the kidneys: the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease, from diet and medication to renal replacement therapy.

Dialysis manual removal of nitrogenous waste and toxin from the body

In medicine, dialysis is the process of removing excess water, solutes, and toxins from the blood in people whose kidneys can no longer perform these functions naturally. This is referred to as renal replacement therapy.

Robert Koffler Jarvik, M.D. is an American scientist, researcher and entrepreneur known for his role in developing the Jarvik-7 artificial heart.

Chronic kidney disease progressive loss in kidney function over a period of months or years

Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months or years. Early on there are typically no symptoms. Later, leg swelling, feeling tired, vomiting, loss of appetite, or confusion may develop. Complications may include heart disease, high blood pressure, bone disease, or anemia.

Kidney transplantation surgical operation

Kidney transplantation or renal transplantation is the organ transplant of a kidney into a patient with end-stage renal disease. Kidney transplantation is typically classified as deceased-donor or living-donor transplantation depending on the source of the donor organ.

Home hemodialysis

Home hemodialysis (HHD), is the provision of hemodialysis to purify the blood of a person whose kidneys are not working normally, in their own home.

Liver dialysis is a detoxification treatment for liver failure and has shown promise for patients with hepatorenal syndrome. It is similar to hemodialysis and based on the same principles. Like a bioartificial liver device, it is a form of artificial extracorporeal liver support.

Artificial kidney is often a synonym for hemodialysis, but may also, refer to renal replacement therapies that are in use and/or in development. This article deals with bioengineered kidneys/bioartificial kidneys that are grown from renal cell lines/renal tissue.

Renal replacement therapy (RRT) is therapy that replaces the normal blood-filtering function of the kidneys. It is used when the kidneys are not working well, which is called renal failure and includes acute kidney injury and chronic kidney disease. Renal replacement therapy includes dialysis, hemofiltration, and hemodiafiltration, which are various ways of filtration of blood with or without machines. Renal replacement therapy also includes kidney transplantation, which is the ultimate form of replacement in that the old kidney is replaced by a donor kidney.

Belding Hibbard Scribner was a U.S. physician and a pioneer in kidney dialysis.

Hemoperfusion or hæmoperfusion is a method of filtering the blood extracorporeally to remove a toxin. As with other extracorporeal methods, such as hemodialysis (HD), hemofiltration (HF), and hemodiafiltration (HDF), the blood travels from the patient into a machine, gets filtered, and then travels back into the patient, typically by venovenous access.

Nils Alwall, a Swedish professor, was a pioneer in hemodialysis and the inventor of one of the first practical dialysis machines. Alwall pioneered the technique of ultrafiltration and introduced the principle of hemofiltration. Alwall is referred to as the "father of extracorporeal blood treatment."

Joseph W. Eschbach American medical researcher

Joseph Wetherill Eschbach was an American doctor and kidney specialist whose twenty years of research starting in the 1960s led to an improvement in the treatment of anemia.

Northwest Kidney Centers

Northwest Kidney Centers is a regional, not-for-profit community-based provider of kidney dialysis, public health education, and research into the causes and treatments of chronic kidney disease. Established in Seattle in 1962, it was the world's first out-of-hospital dialysis provider. It offers dialysis throughout the greater Seattle area in 15 free-standing clinics, nine hospitals and its home dialysis program. Three more clinic are scheduled to open in 2018.

Nathan W. Levin is an American physician and founder of the Renal Research Institute, LLC., a research institute dedicated to improving the outcomes of patients with kidney disease, particularly those requiring dialysis. Levin is one of the most prominent and renowned figures in clinical nephrology as well as nephrology research. He has authored multiple book chapters and over 350 peer-reviewed publications, including articles in leading journals such as Nature, the New England Journal of Medicine, and The Lancet.

Keith Reemtsma American surgeon

Keith Reemtsma was an American transplant surgeon, best known for the cross-species kidney transplantation operation from chimpanzee to human in 1964. With only the early immunosuppressants and no long-term dialysis, the female recipient survived nine months, long enough to return to work.

Sir Graham MacGregor Bull was a South African-British physician, nephrologist, medical administrator, and director of medical research.

References

  1. Editor, ÖGV. (2015). Wilhelm Exner Medal. Austrian Trade Association. ÖGV. Austria.
  2. Cooley, Denton A. (2009). "In Memoriam". Texas Heart Institute Journal. 36 (2): 83–84. ISSN   0730-2347. PMC   2676591 .
  3. 1 2 3 4 Moore, Carrie A. "Kolff, 'father of artificial organs,' dies at 97", Deseret News , February 11, 2009. Accessed February 11, 2009.
  4. John Francis Maher (1 January 1989). Replacement of Renal Function by Dialysis: A Text Book of Dialysis. Springer. pp. 33–33. ISBN   978-0-89838-414-7.
  5. New York Times: "DAVID ROSE" July 18, 1986
  6. "Willem Johan Kolff (1911 - 2009)". Royal Netherlands Academy of Arts and Sciences. Retrieved 24 January 2016.
  7. Milestones, Time Magazine, March 2, 2009, p.18
  8. "Yad Vashem Web Site" . Retrieved 28 July 2018.

Sources