Centalun

Last updated
Centalun
Centalun.svg
Clinical data
ATC code
  • none
Legal status
Legal status
  • In general: unscheduled
Identifiers
  • 2-methyl-1-phenylbut-3-yne-1,2-diol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C11H12O2
Molar mass 176.215 g·mol−1
3D model (JSmol)
  • OC(c1ccccc1)C(C#C)(O)C
  • InChI=1S/C11H12O2/c1-3-11(2,13)10(12)9-7-5-4-6-8-9/h1,4-8,10,12-13H,2H3 X mark.svgN
  • Key:GQOXDWHRXDPZJK-UHFFFAOYSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Centalun was developed by Boehringer Ingelheim in 1962 [1] and is a psycholeptic drug with hypnotic and sedative effects, via allosteric agonism of the GABAA receptor. [2] It was previously used for sedation in medical procedures such as surgery, [3] orthopedics [4] and gynecology, [5] although it is no longer in clinical use. Despite its history of clinical use, centalun was never incorporated into the CSA and therefore remains unregulated as a drug of abuse.

References

  1. ↑ BE 618130,"Procédé pour l'obtention d'alkinediols"
  2. ↑ Janke W, Glathe H (June 1964). "[Experimental Studies on the Psychic Effect of Sedatives Under Normal and Stress Conditions]". Psychologische Forschung (in German). 27: 377–402. doi:10.1007/bf00421338. PMID   14233519. S2CID   144088161.
  3. ↑ Monecke K (July 1964). "[Pre- and Postoperative Use of Centalun in Surgery]". Deutsches Medizinisches Journal (in German). 15: 470–1. PMID   14238754.
  4. ↑ Bruckschen E (July 1964). "[Sedative Therapy with Centalun in Orthopedics]". Deutsches Medizinisches Journal (in German). 15: 493–4. PMID   14243120.
  5. ↑ Gerlach W, Gerlach E (March 1964). "[Experiences with Centalun in Obstetrical and Gynecological Patients]". Medizinische Monatsschrift (in German). 18: 131–3. PMID   14193290.
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