ATPase, Na+/K+ transporting, alpha 1

ATP1A1
Identifiers
Aliases	ATP1A1 , ATPase, Na+/K+ transporting, alpha 1, ATPase Na+/K+ transporting subunit alpha 1, CMT2DD, HOMGSMR2
External IDs	OMIM: 182310 MGI: 88105 HomoloGene: 564 GeneCards: ATP1A1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.1 Start 116,372,668 bp [1] End 116,410,261 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F2.2|3 44.3 cM Start 101,483,535 bp [2] End 101,512,000 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla right lobe of thyroid gland left lobe of thyroid gland cerebellar hemisphere kidney gallbladder islet of Langerhans duodenum rectum body of pancreas Top expressed in kidney submandibular gland left colon parotid gland duodenum stria vascularis cerebellar cortex respiratory epithelium upper respiratory tract olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function steroid hormone binding nucleotide binding chaperone binding protein domain specific binding phosphatase activity ADP binding potassium ion binding sodium ion binding P-type sodium:potassium-exchanging transporter activity metal ion binding phosphatidylinositol 3-kinase binding protein binding ankyrin binding hydrolase activity ATP binding protein kinase binding P-type potassium transmembrane transporter activity Cellular component integral component of membrane extracellular vesicle endosome Golgi apparatus membrane intercalated disc T-tubule melanosome myelin sheath plasma membrane sodium:potassium-exchanging ATPase complex basolateral plasma membrane apical plasma membrane endoplasmic reticulum caveola membrane raft sarcolemma extracellular exosome postsynaptic density protein-containing complex Biological process cellular response to steroid hormone stimulus regulation of cardiac conduction membrane hyperpolarization regulation of sodium ion transport regulation of the force of heart contraction negative regulation of heart contraction sodium ion transport cellular sodium ion homeostasis sodium ion export across plasma membrane cell communication by electrical coupling involved in cardiac conduction response to glycoside ion transport cellular potassium ion homeostasis regulation of blood pressure potassium ion transport positive regulation of heart contraction ion transmembrane transport cellular response to mechanical stimulus regulation of cardiac muscle cell contraction membrane repolarization positive regulation of striated muscle contraction negative regulation of glucocorticoid biosynthetic process membrane repolarization during cardiac muscle cell action potential relaxation of cardiac muscle dephosphorylation potassium ion import across plasma membrane establishment or maintenance of transmembrane electrochemical gradient cardiac muscle cell action potential involved in contraction transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 476 11928 Ensembl ENSG00000163399 ENSMUSG00000033161 UniProt P05023 Q5TC02 Q8VDN2 RefSeq (mRNA) NM_000701 NM_001001586 NM_001160233 NM_001160234 NM_144900 RefSeq (protein) NP_000692 NP_001153705 NP_001153706 NP_659149 Location (UCSC) Chr 1: 116.37 – 116.41 Mb Chr 3: 101.48 – 101.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gastric H+/K+-ATPase, N terminal domain
tfe-induded structure of the n-terminal domain of pig gastric h/k-atpase
Identifiers
Symbol	H-K_ATPase_N
Pfam	PF09040
InterPro	IPR015127
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Sodium/potassium-transporting ATPase subunit alpha-1 is an enzyme that in humans is encoded by the ATP1A1 gene. ^[5]

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na⁺/K⁺-ATPases. Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na⁺/K⁺-ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. ^[5]

In melanocytic cells ATP1A1 gene expression may be regulated by MITF. ^[6]

Clinical relevance

Mutations in this gene have been associated with aldosterone-producing adenomas and secondary hypertension. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000163399 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033161 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ATP1A1 ATPase, Na⁺/K⁺ transporting, alpha 1 polypeptide".
6. Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (December 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID   19067971.
7. Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen HN, Lichtenauer UD, Penton D, Schack VR, Amar L, Fischer E, Walther A, Tauber P, Schwarzmayr T, Diener S, Graf E, Allolio B, Samson-Couterie B, Benecke A, Quinkler M, Fallo F, Plouin PF, Mantero F, Meitinger T, Mulatero P, Jeunemaitre X, Warth R, Vilsen B, Zennaro MC, Strom TM, Reincke M (April 2013). "Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension". Nature Genetics. 45 (4): 440–4, 444e1-2. doi:10.1038/ng.2550. hdl:11577/2573243. PMID   23416519. S2CID   205346722.

Further reading

• Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na,K-ATPase". Progress in Nucleic Acid Research and Molecular Biology. 38: 37–89. doi:10.1016/S0079-6603(08)60708-4. ISBN   9780125400381. PMID   2158121.
• Dunbar LA, Caplan MJ (August 2001). "Ion pumps in polarized cells: sorting and regulation of the Na+, K+- and H+, K+-ATPases". The Journal of Biological Chemistry. 276 (32): 29617–20. doi: 10.1074/jbc.R100023200 . PMID   11404365.
• Wangemann P (March 2002). "K+ cycling and the endocochlear potential". Hearing Research. 165 (1–2): 1–9. doi:10.1016/S0378-5955(02)00279-4. PMID   12031509. S2CID   18118568.
• Xie Z, Cai T (May 2003). "Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function". Molecular Interventions. 3 (3): 157–68. doi:10.1124/mi.3.3.157. PMID   14993422.
• Shull MM, Pugh DG, Lingrel JB (March 1990). "The human Na, K-ATPase alpha 1 gene: characterization of the 5'-flanking region and identification of a restriction fragment length polymorphism". Genomics. 6 (3): 451–60. doi:10.1016/0888-7543(90)90475-A. PMID   1970326.
• Herrera VL, Ruiz-Opazo N (August 1990). "Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution". Science. 249 (4972): 1023–6. doi:10.1126/science.1975705. PMID   1975705.
• Kawakami K, Ohta T, Nojima H, Nagano K (August 1986). "Primary structure of the alpha-subunit of human Na,K-ATPase deduced from cDNA sequence". Journal of Biochemistry. 100 (2): 389–97. doi:10.1093/oxfordjournals.jbchem.a121726. PMID   2430951.
• Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U (February 1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes". Genomics. 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID   2842249.
• Sverdlov ED, Broude NE, Sverdlov VE, Monastyrskaya GS, Grishin AV, Petrukhin KE, Akopyanz NS, Modyanov NN (August 1987). "Family of Na+,K+-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism". FEBS Letters. 221 (1): 129–33. doi: 10.1016/0014-5793(87)80366-6 . PMID   2887455.
• Chehab FF, Kan YW, Law ML, Hartz J, Kao FT, Blostein R (November 1987). "Human placental Na+,K+-ATPase alpha subunit: cDNA cloning, tissue expression, DNA polymorphism, and chromosomal localization". Proceedings of the National Academy of Sciences of the United States of America. 84 (22): 7901–5. Bibcode:1987PNAS...84.7901C. doi: 10.1073/pnas.84.22.7901 . PMC   299443 . PMID   2891135.
• Monastyrskaya GS, Broude NE, Allikmets RL, Melkov AM, Malyshev IV, Dulubova IE, Petrukhin KE (March 1987). "The family of human Na+,K+-ATPase genes. A partial nucleotide sequence related to the alpha-subunit". FEBS Letters. 213 (1): 73–80. doi: 10.1016/0014-5793(87)81467-9 . PMID   3030810.
• Shull MM, Lingrel JB (June 1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit". Proceedings of the National Academy of Sciences of the United States of America. 84 (12): 4039–43. Bibcode:1987PNAS...84.4039S. doi: 10.1073/pnas.84.12.4039 . PMC   305017 . PMID   3035563.
• Sverdlov ED, Monastyrskaya GS, Broude NE, Allikmets RL, Melkov AM, Malyshev IV, Dulobova IE, Petrukhin KE (June 1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit". FEBS Letters. 217 (2): 275–8. doi: 10.1016/0014-5793(87)80677-4 . PMID   3036582.
• Ruiz A, Bhat SP, Bok D (April 1995). "Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium". Gene. 155 (2): 179–84. doi:10.1016/0378-1119(94)00812-7. PMID   7536695.
• Hundal HS, Maxwell DL, Ahmed A, Darakhshan F, Mitsumoto Y, Klip A (1995). "Subcellular distribution and immunocytochemical localization of Na,K-ATPase subunit isoforms in human skeletal muscle". Molecular Membrane Biology. 11 (4): 255–62. doi:10.3109/09687689409160435. PMID   7711835.
• Feschenko MS, Sweadner KJ (June 1995). "Structural basis for species-specific differences in the phosphorylation of Na,K-ATPase by protein kinase C". The Journal of Biological Chemistry. 270 (23): 14072–7. doi: 10.1074/jbc.270.23.14072 . PMID   7775468.
• Ruiz-Opazo N, Barany F, Hirayama K, Herrera VL (September 1994). "Confirmation of mutant alpha 1 Na,K-ATPase gene and transcript in Dahl salt-sensitive/JR rats". Hypertension. 24 (3): 260–70. doi: 10.1161/01.hyp.24.3.260 . PMID   8082931.
• Zahler R, Gilmore-Hebert M, Baldwin JC, Franco K, Benz EJ (July 1993). "Expression of alpha isoforms of the Na,K-ATPase in human heart". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1149 (2): 189–94. doi:10.1016/0005-2736(93)90200-J. PMID   8391840.
• Wang J, Schwinger RH, Frank K, Müller-Ehmsen J, Martin-Vasallo P, Pressley TA, Xiang A, Erdmann E, McDonough AA (October 1996). "Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart". The Journal of Clinical Investigation. 98 (7): 1650–8. doi:10.1172/JCI118960. PMC   507599 . PMID   8833915.