Amlodipine/valsartan

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Amlodipine/valsartan
Amlodipine.svg
Valsartan skeletal.svg
Combination of
Amlodipine Calcium channel blocker
Valsartan Angiotensin II receptor antagonist
Clinical data
Trade names Exforge
AHFS/Drugs.com Professional Drug Facts
License data
Pregnancy
category
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
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Amlodipine/valsartan, sold under the brand name Exforge among others, is a blood pressure lowering combination drug. It contains amlodipine, as the besilate, a dihydropyridine-type calcium channel blocker, and valsartan, an angiotensin II receptor antagonist. [3] This combination is usually well tolerated and effective for the reduction of blood pressure. [4]

The combination was approved for medical use in the United States in June 2007. [5]

The combination is also available with included hydrochlorothiazide (Exforge HCT), for people who need a three-drug regimen to manage their blood pressure. [6] [7] It was approved for medical use in the United States in April 2009. [8]

Related Research Articles

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References

  1. "Amlodipine / valsartan (Exforge) Use During Pregnancy". Drugs.com. 11 July 2019. Retrieved 13 February 2020.
  2. "Exforge- amlodipine besylate and valsartan tablet, film coated". DailyMed. 12 June 2019. Retrieved 12 February 2020.
  3. "Valsartan Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  4. Eckert S, Freytag SB, Müller A, Klebs SH (September 2013). "Meta-analysis of three observational studies of amlodipine/valsartan in hypertensive patients with additional risk factors". Blood Pressure. 22 (sup1): 11–21. doi:10.3109/08037051.2013.793891. PMID   23713686. S2CID   25814898.
  5. "Drug Approval Package: Exforge (amlodipine and valsartan) NDA #021990". U.S. Food and Drug Administration (FDA). 3 October 2008. Retrieved 19 September 2021.
  6. "Exforge HCT- amlodipine valsartan and hydrochlorothiazide tablet, film coated". DailyMed. Retrieved 12 February 2020.
  7. "Amlodipine, Valsartan, and Hydrochlorothiazide". Drugs.com.
  8. "Drug Approval Package: Exforge HCT (Amlodipine, Valsartan, Hydrochlorothiazide) Tablets NDA #022314". U.S. Food and Drug Administration (FDA). 2 September 2009. Retrieved 19 September 2021.