Jay Scott Greenspan, known professionally as Jason Alexander, is an American actor and comedian. He played George Costanza in the television series Seinfeld from 1989 to 1998, for which he was nominated for seven consecutive Primetime Emmy Awards and four Golden Globe Awards.
Seinfeld is an American television sitcom created by Larry David and Jerry Seinfeld that originally aired on NBC from July 5, 1989 to May 14, 1998, with a total of nine seasons consisting of 180 episodes. The show's ensemble cast stars Seinfeld as a fictionalized version of himself and focuses on his personal life with three of his friends: best friend George Costanza, former girlfriend Elaine Benes, and neighbor from across the hall, Cosmo Kramer.
Lawrence Gene David is an American comedian, writer, actor, and television producer. He and Jerry Seinfeld created the television sitcom Seinfeld, of which David was head writer and executive producer for the first seven seasons. He gained further recognition for creating and writing the HBO series Curb Your Enthusiasm, in which he also stars as a fictionalized version of himself. David's work on Seinfeld won him two Primetime Emmy Awards in 1993, for Outstanding Comedy Series and Outstanding Individual Achievement in Writing in a Comedy Series; he was nominated 17 other times.
Severe combined immunodeficiency (SCID), also known as Swiss-type agammaglobulinemia, is a rare genetic disorder characterized by the disturbed development of functional T cells and B cells caused by numerous genetic mutations that result in differing clinical presentations. SCID involves defective antibody response due to either direct involvement with B lymphocytes or through improper B lymphocyte activation due to non-functional T-helper cells. Consequently, both "arms" of the adaptive immune system are impaired due to a defect in one of several possible genes. SCID is the most severe form of primary immunodeficiencies, and there are now at least nine different known genes in which mutations lead to a form of SCID. It is also known as the bubble boy disease and bubble baby disease because its victims are extremely vulnerable to infectious diseases and some of them, such as David Vetter, have become famous for living in a sterile environment. SCID is the result of an immune system so highly compromised that it is considered almost absent.
Roger François Jouret, better known as Plastic Bertrand, is a Belgian musician, songwriter, producer, editor and television presenter, best known for the 1977 international hit single "Ça plane pour moi".
Bubble Boy is a 2001 American black comedy film directed by Blair Hayes, starring Jake Gyllenhaal in the title role. It was inspired by the 1976 movie The Boy in the Plastic Bubble. A musical by the same name was written by the same authors and first performed in 2008.
David Phillip Vetter was an American boy with severe combined immunodeficiency (SCID), a hereditary disease which dramatically weakens the immune system. Individuals born with SCID are abnormally susceptible to infections, and exposure to typically innocuous pathogens can be fatal. Vetter was referred to as "David, the bubble boy" by the media, as a reference to the complex containment system used as part of the management of his SCID. Vetter's surname was not revealed to the general public until 10 years after his death in order to preserve his family's privacy.
Vincent Theodore DeVita Jr. is the Amy and Joseph Perella Professor of Medicine at Yale Cancer Center, and a Professor of Epidemiology and Public Health. He directed the Yale Cancer Center from 1993 to 2003. He has been president of the board of directors of the American Cancer Society (2012-2013). He is internationally recognized as a pioneer in the field of oncology for his work on combination-chemotherapy treatments.
Clinton Engle Howard is an American actor. He is the second son born to American actors Rance and Jean Howard, and younger brother of actor and director Ron Howard. His 200-plus acting credits include feature films such as The Waterboy and Apollo 13, as well as television series, such as Gentle Ben, The Baileys of Balboa, The Cowboys, My Name Is Earl, and several entries in the Star Trek franchise. He has appeared in many films directed by his brother, Ron, and had a small role in the 1967 animated film The Jungle Book. He is lead singer of his own band, The Kempsters, and also makes custom snow globes.
Larry Charles is an American comedian, screenwriter, director, actor, and producer. He was a staff writer for the sitcom Seinfeld for its first five seasons. He has also directed the documentary film Religulous and the mockumentary comedy films Borat, Brüno, and The Dictator. His Netflix documentary series Larry Charles' Dangerous World of Comedy premiered in 2019.
Theodore David DeVita was an American boy with severe aplastic anemia requiring him to live in a sterile hospital room for the last eight years of his life.
The Boy in the Plastic Bubble is a 1976 American made for television drama film inspired by the lives of David Vetter and Ted DeVita, who lacked effective immune systems. It stars John Travolta, Glynnis O'Connor, Diana Hyland, Robert Reed, Ralph Bellamy and P.J. Soles. It was written by Douglas Day Stewart, produced by Aaron Spelling and Leonard Goldberg, and directed by Randal Kleiser, who would work with Travolta again in the 1978 hit musical film adaptation of Grease shortly after. The original music score was composed by Mark Snow. The theme song "What Would They Say" was written and sung by Paul Williams. William Howard Taft High School was used for filming.
X-linked severe combined immunodeficiency (X-SCID) is an immunodeficiency disorder in which the body produces very few T cells and NK cells.
Elizabeth DeVita-Raeburn is an American author and journalist who covers science, health, and society. She is the author of The Empty Room, a memoir of the death of her older brother, Ted DeVita, who lived for eight years in a plastic bubble at the National Institute of Health Clinical Center before dying of iron overload from the transfusions he had as treatment of his severe immune disorder at the age of 17. Her father is Dr. Vincent T. DeVita.
"The Virgin" is the 50th episode of the sitcom Seinfeld. It was the tenth episode of the fourth season. It aired on November 11, 1992. The cast assembled to read this episode's script on October 14, 1992, and it was filmed six days later, on October 20. In this episode, Jerry's current relationship runs into trouble after his girlfriend confides in him that she is a virgin, and he and George struggle to come up with episode ideas for the Jerry show in the last few days before they must pitch the show to NBC executives.
SpongeBob's Atlantis SquarePantis is the first television film and the 92nd episode of the American animated television series SpongeBob SquarePants, and a 2007 made-for-television musical comedy film directed by Andrew Overtoom. It first aired on Nickelodeon in the United States on November 12, 2007, serving as the twelfth episode of the fifth season of the American animated television series SpongeBob SquarePants. In the special, SpongeBob and Patrick discover a half of an ancient medallion that helps them and their friends get to the lost city of Atlantis.
The severe combined immunodeficiency (SCID) is a severe immunodeficiency genetic disorder that is characterized by the complete inability of the adaptive immune system to mount, coordinate, and sustain an appropriate immune response, usually due to absent or atypical T and B lymphocytes. In humans, SCID is colloquially known as "bubble boy" disease, as victims may require complete clinical isolation to prevent lethal infection from environmental microbes.
"The Bubble Boy" is the 47th episode of the American sitcom Seinfeld. It is the seventh episode of the fourth season. In this episode, on the way to Susan's family cabin, the cast visits a youth who lives in quarantine due to an immune deficiency.
"The Boy in the Bubble" is a song by the American singer-songwriter Paul Simon. It was the third single from his seventh studio album, Graceland (1986), released on Warner Bros. Records. Written by Simon and Forere Motloheloa, its lyrics explore starvation and terrorism, juxtaposed with wit and optimism.
The Boy In The Bubble is a children's novel written by Ian Strachan and published in 1993. The novel follows the story of Adam, a child born with severe combined immunodeficiency (SCID), and lived his life in an oxygen tent to prevent him from falling ill, and a schoolgirl named Anne who chooses to base her school project on Adam. The novel won the Red House Children's Book Award and was the 1994 Lancashire Book of the Year.
