COMPLEAT (bioinformatics tool)

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Protein Complex Enrichment Analysis Tool is an online bioinformatics tool used to analyze high-throughput datasets (or small-scale datasets) using protein complex enrichment analysis. [1] The tool uses a protein complex resource as the back end annotation data instead of conventional gene ontology- or pathway-based annotations. The tool incorporates several useful features in order to provide a comprehensive data-mining environment, including network-based visualization and interactive querying options.

Contents

COMPLEAT may be used to analyze RNAi screens, proteomic datasets, gene expression data and any other high-throughput datasets where protein complex information is relevant.

Applications

COMPLEAT has been successfully applied to identify:

References

  1. 1 2 Vinayagam, A; Hu, Y; Kulkarni, M; Roesel, C; Sopko, R; Mohr, SE; Perrimon, N (Feb 26, 2013). "Protein complex-based analysis framework for high-throughput data sets". Science Signaling. 6 (264): rs5. doi:10.1126/scisignal.2003629. PMC   3756668 . PMID   23443684.
  2. ↑ Neumüller, R.A; Gross, T; Samsonova, A; Vinayagam, A; Buckner, M; Founk, K; Hu, Y; Sharifpoor, S; Rosebrock, AP; Andrews, B; Winston, F; Perrimon, N (Aug 20, 2013). "Conserved Regulators of Nucleolar Size Revealed by Global Phenotypic Analyses". Science Signaling. 6 (289): ra70. doi:10.1126/scisignal.2004145. PMC   3964804 . PMID   23962978.
  3. ↑ Kwon, Y; Vinayagam, A; Sun, X; Dephoure, N; Gygi, S.P; Hong, P; Perrimon, N (2013). "The Hippo Signaling Pathway Interactome". Science. 342 (6159): 737–40. Bibcode:2013Sci...342..737K. doi:10.1126/science.1243971. PMC   3951131 . PMID   24114784.
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