CTBS

CTBS
Identifiers
Aliases	CTBS , CTB, chitobiase
External IDs	OMIM: 600873 MGI: 1921495 HomoloGene: 3231 GeneCards: CTBS
Gene location (Human)
Chr.	Chromosome 1 (human)
End	84,574,480 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	146,171,604 bp
RNA expression pattern
	Top expressed in
	monocyte; ; retinal pigment epithelium; ; blood; ; islet of Langerhans; ; stromal cell of endometrium; ; right lobe of liver; ; ascending aorta; ; gallbladder; ; rectum; ; right coronary artery;
	Top expressed in
	proximal tubule; ; kidney; ; secondary oocyte; ; medullary collecting duct; ; liver; ; spermatocyte; ; dermis; ; left lung lobe; ; endocardial cushion; ; atrioventricular valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	hydrolase activity, hydrolyzing O-glycosyl compounds ; hydrolase activity ; hydrolase activity, acting on glycosyl bonds ; chitinase activity ; chitin binding ;
Cellular component	lysosome ; extracellular exosome ; extracellular space ;
Biological process	oligosaccharide catabolic process ; metabolism ; chitin catabolic process ; carbohydrate metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	1486
	74245
	ENSG00000117151
	ENSMUSG00000028189
	Q01459
	Q8R242
	NM_004388
	NM_001293672 ; NM_028836
	NP_004379
	NP_001280601 ; NP_083112
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 14, 2023

Di-N-acetylchitobiase is an enzyme that in humans is encoded by the CTBS gene.^[5]^[6]^[7]

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Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 is a protein that in humans is encoded by the GNG5 gene.

Ghk.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117151 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028189 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fisher KJ, Aronson NN Jr (Apr 1992). "Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)". Mol Cell Biol. 12 (4): 1585–91. doi:10.1128/mcb.12.4.1585. PMC 369601 . PMID 1549114.
↑ Ahmad W, Li S, Chen H, Tuck-Muller CM, Pittler SJ, Aronson NN Jr (Aug 1995). "Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22". Cytogenet Cell Genet. 71 (1): 44–6. doi:10.1159/000134059. PMID 7606925.
↑ "Entrez Gene: CTBS chitobiase, di-N-acetyl-".

External links

Human CTBS genome location and CTBS gene details page in the UCSC Genome Browser .

Aronson NN, Halloran BA (2006). "Optimum substrate size and specific anomer requirements for the reducing-end glycoside hydrolase di-N-acetylchitobiase". Biosci. Biotechnol. Biochem. 70 (6): 1537–41. doi: 10.1271/bbb.60183 . PMID 16794344. S2CID 1848335.
Kamioka Y, Fukuhara S, Sawa H, et al. (2004). "A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis". J. Biol. Chem. 279 (38): 40091–9. doi: 10.1074/jbc.M404899200 . PMID 15252009.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Hutchinson T, Dwivedi K, Rastogi A, et al. (2002). "N-acetyl beta-D-glucosaminidase is not attached to human sperm membranes through the glycosylphosphatidyl inositol (GPI)-anchor". Asian J. Androl. 4 (1): 27–33. PMID 11907625.
Liu B, Ahmad W, Aronson NN (1999). "Structure of the human gene for lysosomal di-N-acetylchitobiase". Glycobiology. 9 (6): 589–93. doi: 10.1093/glycob/9.6.589 . PMID 10336991.
Aronson NN, Backes M, Kuranda MJ (1989). "Rat liver chitobiase: purification, properties, and role in the lysosomal degradation of Asn-linked glycoproteins". Arch. Biochem. Biophys. 272 (2): 290–300. doi:10.1016/0003-9861(89)90222-1. PMID 2751306.
Fisher KJ, Aronson NN (1992). "Cloning and expression of the cDNA sequence encoding the lysosomal glycosidase di-N-acetylchitobiase". J. Biol. Chem. 267 (27): 19607–16. doi: 10.1016/S0021-9258(18)41818-2 . PMID 1527079.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117151 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028189 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1549114-5] Fisher KJ, Aronson NN Jr (Apr 1992). "Characterization of the cDNA and genomic sequence of a G protein gamma subunit (gamma 5)". Mol Cell Biol. 12 (4): 1585–91. doi:10.1128/mcb.12.4.1585. PMC 369601 . PMID 1549114.

[pmid7606925-6] Ahmad W, Li S, Chen H, Tuck-Muller CM, Pittler SJ, Aronson NN Jr (Aug 1995). "Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5) genes co-localize to human chromosome 1p22". Cytogenet Cell Genet. 71 (1): 44–6. doi:10.1159/000134059. PMID 7606925.

[entrez-7] "Entrez Gene: CTBS chitobiase, di-N-acetyl-".

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CTBS

Contents

Related Research Articles

References

External links

Further reading