Calcium/calmodulin dependent protein kinase II inhibitor 1

CAMK2N1
Identifiers
Aliases	CAMK2N1 , PRO1489, calcium/calmodulin dependent protein kinase II inhibitor 1
External IDs	OMIM: 614986 MGI: 1913509 HomoloGene: 10238 GeneCards: CAMK2N1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.12 Start 20,482,391 bp [1] End 20,486,210 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D3 Start 138,181,625 bp [2] End 138,187,434 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 46 parietal lobe postcentral gyrus entorhinal cortex orbitofrontal cortex middle temporal gyrus occipital lobe internal globus pallidus superior frontal gyrus dorsolateral prefrontal cortex Top expressed in prefrontal cortex olfactory tubercle cingulate gyrus primary motor cortex globus pallidus piriform cortex temporal lobe amygdala medial dorsal nucleus visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein kinase inhibitor activity calcium-dependent protein kinase inhibitor activity protein kinase binding Cellular component neuron projection cell junction neuronal cell body postsynaptic membrane plasma membrane dendrite synapse membrane postsynaptic density intracellular anatomical structure cellular component Biological process negative regulation of protein kinase activity negative regulation of cell population proliferation positive regulation of gene expression negative regulation of cell cycle negative regulation of proteolysis negative regulation of ERK1 and ERK2 cascade negative regulation of cyclin-dependent protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55450 66259 Ensembl ENSG00000162545 ENSMUSG00000046447 UniProt Q7Z7J9 Q6QWF9 RefSeq (mRNA) NM_018584 NM_025451 RefSeq (protein) NP_061054 NP_079727 Location (UCSC) Chr 1: 20.48 – 20.49 Mb Chr 4: 138.18 – 138.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Calcium/calmodulin dependent protein kinase II inhibitor 1 is a protein that in humans is encoded by the CAMK2N1 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000162545 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046447 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Calcium/calmodulin dependent protein kinase II inhibitor 1" . Retrieved 2017-09-09.

Further reading

• Wang C, Li N, Liu X, Zheng Y, Cao X (2008). "A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization". J. Biol. Chem. 283 (17): 11565–74. doi: 10.1074/jbc.M800436200 . PMC   2431061 . PMID   18305109.
• Wang T, Liu Z, Guo S, Wu L, Li M, Yang J, Chen R, Xu H, Cai S, Chen H, Li W, Wang L, Hu Z, Zhuang Q, Xu S, Wang L, Liu J, Ye Z, Ji JY, Wang C, Chen K (2014). "The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer". Oncotarget. 5 (11): 3611–21. doi:10.18632/oncotarget.1968. PMC   4116507 . PMID   25003983.
• Wang T, Guo S, Liu Z, Wu L, Li M, Yang J, Chen R, Liu X, Xu H, Cai S, Chen H, Li W, Xu S, Wang L, Hu Z, Zhuang Q, Wang L, Wu K, Liu J, Ye Z, Ji JY, Wang C, Chen K (2014). "CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling". Oncotarget. 5 (21): 10293–306. doi:10.18632/oncotarget.2511. PMC   4279373 . PMID   25296973.
• Häfner N, Steinbach D, Jansen L, Diebolder H, Dürst M, Runnebaum IB (2016). "RUNX3 and CAMK2N1 hypermethylation as prognostic marker for epithelial ovarian cancer". Int. J. Cancer. 138 (1): 217–28. doi: 10.1002/ijc.29690 . PMID   26175272.