The Men's C-2 500m event at the 2010 South American Games was held over March 28 at 10:20.
The IX South American Games was a multi-sport event held between 19–30 March 2010 in Medellín, Colombia. The Games were organized by the South American Sports Organization (ODESUR), who awarded the Games to the city with 8 votes over the bid by previous host Santiago, Chile.
| Gold | Silver | Bronze |
| Ronilson de Oliveira Erlon Silva  | Eduyn Labarca Edward Luciano Paredes  | Anders Ospina Jesus Felipe Ospina  |
| Rank | Athlete | Time |
|---|---|---|
 | Ronilson de Oliveira Erlon Silva | 1:46.45 |
 | Eduyn Labarca Edward Luciano Paredes | 1:47.67 |
 | Anders Ospina Jesus Felipe Ospina | 1:48.40 |
| 4 |  Johnnathan Francisco Quitral Alvaro Dario Raguileo | 1:53.82 |
| 5 |  Leonardo Niveiro Roberto Palacios | 1:58.21 |